DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	462	Identity:	99/462 - (21%)
Similarity:	175/462 - (37%)	Gaps:	146/462 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 FVLCMIYMFLPIPS---SKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVS------- 211
            ::|..::|....||   ||..:.|.|..||....:..|||...:..:.::.:|:..:.
Human   252 YLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQG 316

  Fly   212 ----IDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQ--------------------FITEE--- 249
                .::|..|...:...|..||  ||:...|:.|.:                    :|.|.
Human   317 KPNFEEYFEILTPKINQTFSGIM--TMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAI 379

  Fly   250 ------------------IWL----------------RQARRQESL------------------- 261
                              ::|                .|||.|:.|
Human   380 LFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALE 444

  Fly   262 --------LLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADL 318
                    ||.||.|.::|:.:.:.   :::|             |:.|      ::|::|::|:
Human   445 EEKKKTVDLLCSIFPCEVAQQLWQG---QVVQ-------------AKKF------SNVTMLFSDI 487

  Fly   319 VNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSL 383
            |.:|.:.:..:..:::.:|:.||.|||.......|.:::.:||.|....||.:....||.....:
Human   488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALM 552

  Fly   384 GISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVH 448
            .:.|:....||.......|.||||:|||::||||:|....:|.::|.:|.:|::.|:...|..::
Human   553 ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKIN 617

  Fly   449 VSGRTLSSLNAEEYNIYPGTESAQKD-PVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPN-LDLQ 511
            ||               |.|....|| |.....|.|...|.  |:..|:     :.|:.: ||..
Human   618 VS---------------PTTYRLLKDCPGFVFTPRSREELP--PNFPSE-----IPGICHFLDAY 660

  Fly   512 TVGSNRK 518
            ..|:|.|
Human   661 QQGTNSK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	38/231 (16%)
		CYCc	262..464	CDD:214485	52/201 (26%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	51/183 (28%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	30/190 (16%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	53/204 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810