DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXA and Adcy8

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1184 Identity:320/1184 - (27%)
Similarity:516/1184 - (43%) Gaps:278/1184 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 LKARCKELHLEEEYMKY------KIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAI 91
            |:...|...||..|.:|      |..::::.|.| :..|.||::.|.:             .:|.
  Rat   154 LRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDV-LTKLTLLVLHLSL-------------ASAP 204

  Fly    92 FDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKS--NWPLNTL- 153
            .|     .:.|:| :.||....:          .:.|.|||..|...:||..|..  .|...|. 
  Rat   205 MD-----PLKGIL-LGFFTGIEV----------VICALVVVRKDTTSHTYLQYSGVVTWVAMTTQ 253

  Fly   154 ----------------YDVFVLCMIYMFLPIPSSKAAALLA------ISVSLTYVIYFIHFMAFN 196
                            |.:|.|...|..||:|.:  .|:||      :.|:|..:|..:...:.|
  Rat   254 ILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLT--WAILAGLGTSLLQVTLQVLIPRLAVFSIN 316

  Fly   197 EHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLR-QARRQES 260
            :            |......::..|..|||...::|...|.:||:..:.:...:.|. :.:|||.
  Rat   317 Q------------VLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQER 369

  Fly   261 LLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIH--NDVSILYADLVNYTQ 323
            |:| |:||..:           :::..||..::........|..|.||  .:||||:||:..:|.
  Rat   370 LVL-SVLPRFV-----------VLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN 422

  Fly   324 LTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMI 388
            |:|||:.::||::|::|:||||..|......|||.||||||||:||.|...|||...|.:|:|||
  Rat   423 LSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMI 487

  Fly   389 ANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRT 453
            ..|:.|......::.||||:|||::..||:|..|.|:|:|..||:||::||:.|.||.:|:|..|
  Rat   488 KTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAT 552

  Fly   454 LSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLL----TAIPSLDSD---KTIS----------I 501
            |..|:. :||:..| ...:::..|:||.:.|||:    .::.||..|   :::|          .
  Rat   553 LDCLSG-DYNVEEG-HGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATF 615

  Fly   502 VEG--VPNLDLQTV--------GSNRKSQILKPNLLSHEMR-----EEFRKMPVGGFKFQFPWSR 551
            .||  .|.|....:        ...|.|..|.||.|:..:.     ||..|             |
  Rat   616 TEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINK-------------R 667

  Fly   552 RERNL---KNEKVERD-LGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNS 612
            .|..:   ..:|:.|: :..|.:.|||.|:|..|....|.:||.::...:.:...:..|||:..|
  Rat   668 IEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPS 732

  Fly   613 D-------------IFYTGVVINIIA--FFVLTFLLFICWYKKVCWWHSGQNEHRSYGKLSCAIF 662
            .             :.::.:|:...|  :..|..:|     :|.|.|                  
  Rat   733 SRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLIL-----RKTCCW------------------ 774

  Fly   663 HLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDP-FT--CFHP 724
                 |..:::.|..:....||..::...:.::.|:.|:    .|..|...::... ||  |.:|
  Rat   775 -----INETYLARNVIIFASILINFLGAVINILWCDFDK----SIPLKNLTFNSSAVFTDICSYP 830

  Fly   725 --WAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIF------EHSVTTSPY 781
              :.:|.::|::  ....|.|:...||..:......::.|:....||.:|      .||  ...:
  Rat   831 EYFVFTGVLAMV--TCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHS--GEDF 891

  Fly   782 LKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQ---NKQKSADVTNQSIIILLNNILP 843
            |..:.|....:.|.|:.::...:|.|:..::::...:..:   |:.|.....|::   :|.||||
  Rat   892 LGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNEN---MLRNILP 953

  Fly   844 SHVVEVYLSSIA-KHELYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDIITAFDRL 897
            .||...:|.... ..|||.::|..|.||||.:..|          ...:..||:||:||..||.|
  Rat   954 GHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL 1018

  Fly   898 LSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNH 962
            |.. .::..:||||.:|.||||..||                               |..|::..
  Rat  1019 LGE-DRFQDIEKIKTIGSTYMAVSGL-------------------------------SPEKQQCE 1051

  Fly   963 DEVAFI--MATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIW 1025
            |:...:  :|.|:|.|...:...||        .:.:..|:|||||.|.::|||:||.:|.||||
  Rat  1052 DKWGHLCALADFSLALTESIQEINK--------HSFNNFELRIGISHGSVVAGVIGAKKPQYDIW 1108

  Fly  1026 GNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKG----RGEIPTYFVGIDKDL 1086
            |..||:||||:|||:||.|||.:||...|::......|||..:|||    .|:|.|||:      
  Rat  1109 GKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL------ 1167

  Fly  1087 KFMSKKIDRLSENP 1100
                  :.|:..||
  Rat  1168 ------LGRVQPNP 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 61/280 (22%)
CYCc 262..464 CDD:214485 83/203 (41%)
Nucleotidyl_cyc_III 306..489 CDD:299850 83/188 (44%)
CYCc 831..1055 CDD:214485 83/236 (35%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 84/236 (36%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179 7/24 (29%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117
AC_N <158..397 CDD:292831 62/294 (21%)
CYCc 363..561 CDD:214485 86/210 (41%)
Guanylate_cyc 402..586 CDD:278633 84/185 (45%)
DUF1053 614..708 CDD:283888 25/106 (24%)
CYCc 941..1145 CDD:214485 84/246 (34%)
Guanylate_cyc 970..1169 CDD:278633 85/250 (34%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 35/82 (43%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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