DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Adcy10

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	454	Identity:	92/454 - (20%)
Similarity:	155/454 - (34%)	Gaps:	162/454 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 FNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKII 284
            ||....|.:.|       .|:|.|.....:.:||.|...||       .|::...:||.:.|.|:
Mouse   224 FNFDEFFTKCM-------GFMDYYPSGDHKNFLRLACMLES-------DPELELSLQKYVMEIIL 274

  Fly   285 QPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQ----------------LTTTLTV--E 331
            :..:|       :....::|..  ..|:|::.:|:...|                :|:.|.|  .
Mouse   275 KQIDD-------KQLRGYLSEL--RPVTIVFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFRG 330

  Fly   332 KLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGL-GESDPDHATMAVSLGISMIANIKEVS 395
            ::.||.     .||             .|..:.||.|. ||..||..|.|:...:.:.....:|.
Mouse   331 QINKVF-----MFD-------------KGCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVH 377

  Fly   396 VNRSLNIGMRIGVHSGTLFAGVIG-KAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNA 459
            ..|:::    |||.||.:|.|::| ..:.:|.:.|..||||:|: ....||.|.....|....|.
Mouse   378 KIRTVS----IGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARM-MMYYPGIVSCDSVTYDGSNL 437

  Fly   460 EEY-------NIYPGTESAQKDPVLQ---------------------KHP-----------MST- 484
            ..|       .:..|.  |...||.|                     .:|           |||
Mouse   438 PAYFFKELPKKVMKGV--ADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMSTM 500

  Fly   485 --YLLTAIPSLDSDKTISIVEGVPN-------LDLQTVGSNRKS--------------------Q 520
              :|:|      :...:.:.||:|.       ::::.:.|..::                    |
Mouse   501 KDFLMT------NCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQ 559

  Fly   521 ILKPNLLSHE-------------------MREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDL 565
            ||..|:|..:                   :.|:|..:....|..|||.||....:...:.::.|
Mouse   560 ILMANVLGLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	18/70 (26%)
		CYCc	262..464	CDD:214485	51/228 (22%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	54/244 (22%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	48/193 (25%)
		COG3899	485..>959	CDD:226415	24/145 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900