Protein Alignment ACXA and Adcy6

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1160
• Identity: 303/1160 - (26%)
• Similarity: 532/1160 - (45%)
• Gaps: 230/1160 - (19%)

  Fly    30 QSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDL 94
            |.:...:.:...||..|.:|..::..||||:.:.:|:||:..| :...:.....:..|: |:...
  Rat   136 QVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVL-LTFHAAPALPQPAYV-ALLTC 198

  Fly    95 GSLILVTGLLSIN---FFEDFVIRHRWVMTFTST-LSAYVVVLGDIAFNTYYYYKSNWPLNTLYD 155
            .|::.|..::..|   |.:|.:    ||:::... :.|.|.|.|.:|.|........|     ..
  Rat   199 ASVLFVVLMVVCNRHSFRQDSM----WVVSYVVLGILAAVQVGGALAANPRSPSAGLW-----CP 254

  Fly   156 VFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVH---GLDIVSIDFFHY 217
            ||.:.:.|..||| ..:||.|..:.:|..::|     :|::.:|...::.   |.::|.     :
  Rat   255 VFFVYITYTLLPI-RMRAAVLSGLGLSTLHLI-----LAWHLNNGDPFLWKQLGANVVL-----F 308

  Fly   218 LGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEK 282
            |..|.:|:......:...|.:|.:...:|...:.|:...||:..||.|:||..:|..:::.|..|
  Rat   309 LCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK 373

  Fly   283 IIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLA 347
              :.|..|:.:          .||.|::||||:||:..:|.|.:..|.::||..|::|:||||..
  Rat   374 --KEDMMFHKI----------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL 426

  Fly   348 ALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGT 412
            |......|||.||||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:|:|||.
  Rat   427 AAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGR 491

  Fly   413 LFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVL 477
            :..||:|..|.|:|:|..||.:|:.:||.|..|.:|::..||..||. :|.:.|| ...:::..|
  Rat   492 VHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNG-DYEVEPG-RGGERNAYL 554

  Fly   478 QKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILK---PNLLSHEMREE--FRK 537
            ::..:.|:|:........::...:|:      ||...:|....::.   |:......::.  ||:
  Rat   555 KEQCIETFLILGASQKRKEEKAMLVK------LQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQ 613

  Fly   538 MPVGGFKFQFPWSRRERNLKN-----EKVERDLG-----------------IFCVAFKDKSVEWN 580
            |.:...      |:..|..::     ::|:..||                 .|.:.|:.:.:|..
  Rat   614 MGIDDS------SKENRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 672

  Fly   581 YLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF-YTGVVINIIA--FFVLTFLLFICWYKKVC 642
            |..:.|..|...||....:.|.:.:||.:    :| ::.:::.|.|  |.:|...:.||   .||
  Rat   673 YSRKVDPRFGAYVACALLVFCFICFIQFL----VFPHSALILGIYAGIFLLLLVTVLIC---AVC 730

  Fly   643 WWHSGQNEHRSYGKLSCAIF--HLFEKIQHSFVLRLTVYMMIILCYYMVISLI------------ 693
                           ||..|  :..:::..| ::|..|:...:..:.:::..|
  Rat   731 ---------------SCGSFFPNALQRLSRS-IVRSRVHSTAVGVFSVLLVFISAIANMFTCSHT 779

  Fly   694 -LMSCEKDQYEL---DIIESKL--YNYDMD---PF------TCFHPWAYTNMMALILGMSYTFAR 743
             |.:|......|   |:....|  .||.:.   |.      ||..|..:...:.|.|..|..|..
  Rat   780 PLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAPLCEGTAPTCSFPEYFVGSVLLSLLASSVFLH 844

  Fly   744 IPFALKTFIGCAEAVVFVLVVCFQY---------AFIFE--------HSVTTS---------PYL 782
            |     :.||   .:|...|:.|.|         |.||:        |.:.:|         |.:
  Rat   845 I-----SSIG---KLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLASSNETFDGLDCPAV 901

  Fly   783 -KAEIAHSCRVCMML--ITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPS 844
             :..:.:...|.:::  :.:|...:|.|...::::...|....:::..:........||:||||.
  Rat   902 GRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPK 966

  Fly   845 HVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------LRVLNDIITAFDRLL 898
            .|...:|:...:: ||||::...|:||||.:.||.   ::|.:       ||:||:||..||.::
  Rat   967 DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII 1031

  Fly   899 SAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQV-RSRLESSIKEKNH 962
            |. :::..:||||.:|.|||||.||:                  :|..:|| ||.:.:
  Rat  1032 SE-ERFRQLEKIKTIGSTYMAASGLN------------------ASTYDQVGRSHITA------- 1070

  Fly   963 DEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGN 1027
                  :|.:|:.||..:...|        :.:.:..:::||::.|.::|||:||.:|.||||||
  Rat  1071 ------LADYAMRLMEQMKHIN--------EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1121

  Fly  1028 PVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            .||::|||:|||:...||||.:..|.|  :.:.:.|  ||:..|||:||:.|||:
  Rat  1122 TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	61/255 (24%)
		CYCc	262..464	CDD:214485	81/201 (40%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	75/182 (41%)
		CYCc	831..1055	CDD:214485	80/237 (34%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	81/233 (35%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	62/267 (23%)
		CYCc	346..541	CDD:214485	82/207 (40%)
		Guanylate_cyc	382..566	CDD:278633	76/195 (39%)
		DUF1053	594..680	CDD:283888	14/91 (15%)
		CYCc	956..1157	CDD:214485	80/240 (33%)
		Guanylate_cyc	982..1176	CDD:278633	82/235 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010