DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	118/547 - (21%)
Similarity:	217/547 - (39%)	Gaps:	129/547 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KTPYRERFRRCNLEYTNERLWEQSYLKARCKELHLE-EEYMKYKIRLMISSLTVFVPMLILLIVA 71
            |.|.|:.|:    ....||||.:..:.......|:. :|.::.|...:  ::..:||.::....|
  Rat   247 KGPLRDTFQ----PVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGV--NIQKYVPGILTQKFA 305

  Fly    72 LQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVL-GD 135
            |.       ||...|:....|::.|:...     ||  ..||::.|..|...:..|..::.| |.
  Rat   306 LD-------EYFSIIHPQVTFNISSICKF-----IN--SQFVLKTRKEMMPKARKSQPMLKLRGQ 356

  Fly   136 IAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNV 200
            :                ::...:.|||:|..|    |..:|..:..|.      :|......|:.
  Rat   357 M----------------IWMESLRCMIFMCSP----KLRSLQELEESK------MHLSDIAPHDT 395

  Fly   201 AKYVHGLDIVSIDFFHYLGFNMMGIFFRIMND----TMVRSSFLDRYQFITEEI-----WLRQAR 256
            .:     |::                  ::|.    .|..|..|::.:   ||:     .|...:
  Rat   396 TR-----DLI------------------LLNQQRLAEMELSCQLEKKK---EELRVLSNHLAIEK 434

  Fly   257 RQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNY 321
            ::...||.::||..:|..:::                |....|..|      ...:||::|:|.:
  Rat   435 KKTETLLYAMLPEHVANQLKE----------------GRKVAAGEF------ETCTILFSDVVTF 477

  Fly   322 TQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGIS 386
            |.:.......::|.:|:.:|::||.......|.:::.:||.|..|.|:......||....:..:.
  Rat   478 TNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALG 542

  Fly   387 MIANIKEVSVNRSLN------IGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPG 445
            |..:.|||     :|      |.:|:|:|:|.:.|||:|....:|.::|..||.|||:|:.|.|.
  Rat   543 MRISAKEV-----MNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPS 602

  Fly   446 YVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNL-- 508
            .||:|.....:|..:.:.|....|...|.    |..|:||.|  |.:|::  |...:.|.|:.
  Rat   603 KVHLSPTAHRALKNKGFEIVRRGEIEVKG----KGKMTTYFL--IQNLNA--TEDEIMGRPSAPA 659

  Fly   509 ---DLQTVGSNRKSQILKPNLLSHEMR 532
               ::.|.|:..:.....|....|:.:
  Rat   660 DGKEVCTPGNQVRKSPAVPRNTDHQQQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	43/259 (17%)
		CYCc	262..464	CDD:214485	54/207 (26%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	54/188 (29%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	44/253 (17%)
		CYCc	432..622	CDD:214485	54/216 (25%)
		Guanylate_cyc	459..642	CDD:278633	56/199 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810