Protein Alignment ACXA and Gucy2g

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_620611.2
• Gene: Gucy2g / 245708
• RGDID: 621853
• Length: 1103
• Species: Rattus norvegicus
• Alignment Length: 1015
• Identity: 209/1015 - (20%)
• Similarity: 334/1015 - (32%)
• Gaps: 355/1015 - (34%)

  Fly   218 LGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLL-----------DSILPPQI 271
            ||.|.....|.::.  .:..||..  :.:.|:...|..:..||:.|           |.....|:
  Rat   268 LGLNSREFVFLLLQ--QLEDSFWK--EVLAEDKVTRFPKVYESVFLIAPSTYGGSAGDDDFRKQV 328

  Fly   272 AK-----PIQKSI-KEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTV 330
            .:     |.|.|| .|..:.|.:.:.|                 |..:|||.           ||
  Rat   329 YQRLRRPPFQSSISSEDQVSPYSAYLH-----------------DALLLYAQ-----------TV 365

  Fly   331 EKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVS 395
            |:::|...|...                                         |..:|:.::...
  Rat   366 EEMMKAEKDFRD-----------------------------------------GRQLISTLRADQ 389

  Fly   396 VNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAE 460
            |...       |: :|.:.....||..:.|.::.        |:.:|:      ..|.|..|:.:
  Rat   390 VTLQ-------GI-TGPVLLDAQGKRHMDYSVYA--------LQKSGN------GSRFLPFLHYD 432

  Fly   461 EYN--IYPGTESAQKDPVLQKHP-------MSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSN 516
            .:.  |.|..:..........||       ....|....|...:..|.|:...:|.:.|..|.
  Rat   433 SFQKVIRPWRDDLNASGPHGSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVA-- 495

  Fly   517 RKSQILKPNLLSHEMREEFRKMPVGGFKFQF------------------PWSR-RERNLKNEKVE 562
              |......|:...:|.:.:..| |...:|.                  |.|| ...|....|:.
  Rat   496 --SAAAITGLMLWRLRGKVQNHP-GDTWWQIHYDSITLLPQHKPSHRGTPMSRCNVSNASTVKIS 557

  Fly   563 RDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVV------- 620
            .|.|.|...           ||.:.:|...|.|..|....|.||.....:.|....|:
  Rat   558 ADCGSFAKT-----------HQDEELFYAPVGLYQGNHVALCYIGEEAEARIKKPTVLREVWLMC 611

  Fly   621 ----INIIAFF-VLTFLLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYM 680
                .||:.|| |.|....||...:.|...|.::..|:.......||.|      |||
  Rat   612 ELKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDVLRNSDHEMDWIFKL------SFV------- 663

  Fly   681 MIILCYYMVISLILM--------------SCEKDQYELDIIESKLYNYDMDPF----TC------ 721
                 |.:|..::.:              :|..|.:    ::.||..:.:..|    ||
  Rat   664 -----YDIVNGMLFLHGSPLRSHGNLKPSNCLVDSH----MQLKLAGFGLWEFKHGSTCRIYNQE 719

  Fly   722 --FH----------------PWAYTNMMALILGMSYTFARI-----------PF-----ALKTFI 752
              .|                ||:.|..     |..|:||.:           ||     |.:..|
  Rat   720 ATDHSELYWTAPELLRLRELPWSGTPQ-----GDVYSFAILLRDLIHQQAHGPFEDLEAAPEEII 779

  Fly   753 GCA-------------------EAVVFVLVVCF--------QYAFIFEHSVTTSPYLKAEIAHSC 790
            .|.                   |.:|.::..|:        .:..|.:.....||..:..|..|
  Rat   780 SCIKDSRAPVPLRPSLLEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGRVSILDS- 843

  Fly   791 RVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIA 855
              .|..:.|||...: |...:...:|..:.:..:|           ||:.:|||.|.|   ..||
  Rat   844 --MMGKLEMYASHLE-EVVEERTCQLVAEKRKVEK-----------LLSTMLPSFVGE---QLIA 891

  Fly   856 KHELYYENYRMVSVMFAMLTNF------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVG 914
            ...:..|::..|::.|:.:..|      ...|..:::|||:.:.||..:..:..|    |::.:|
  Rat   892 GKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVY----KVETIG 952

  Fly   915 CTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRV 979
            ..||.|.||                        .:|:..:.:      ||:    ||.:|.|
  Rat   953 DAYMVASGL------------------------PIRNGAQHA------DEI----ATMSLHL--- 980

  Fly   980 LSVCNKAYAGE-PFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGH 1043
            |||......|. |.:|.    ::|||:.||.::|||||.:.|.|.::|:.|||||||||:.|...
  Rat   981 LSVTTNFQIGHMPEERL----KLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLR 1041

  Fly  1044 IQVTKETAQTLEEFDVMCYY---RGLTFVKGRGEIPTYFV 1080
            |.|::.||:.|  .....|:   ||...|||:||..|:::
  Rat  1042 IHVSQSTARAL--LVAGGYHLQKRGTISVKGKGEQTTFWL 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	19/89 (21%)
		CYCc	262..464	CDD:214485	32/220 (15%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	27/191 (14%)
		CYCc	831..1055	CDD:214485	67/230 (29%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	68/230 (30%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	42/265 (16%)
		ANF_receptor	66..417	CDD:279440	37/237 (16%)
		PK_GC	558..832	CDD:270894	57/311 (18%)
		CYCc	868..1058	CDD:214485	69/250 (28%)
		Guanylate_cyc	895..1081	CDD:278633	68/232 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810