DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Gucy2f

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus

Alignment Length:	1066	Identity:	212/1066 - (19%)
Similarity:	359/1066 - (33%)	Gaps:	417/1066 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 EEIWLRQARRQESLLLDSILPPQI-------AKPIQKSIKE-------KII-----------QPD 287
            |:||:..|.|..|.|....||..:       ::.|||::::       :||           :..
Mouse   195 EDIWMHTANRVSSALRSQGLPVGVVLTSGRDSQSIQKALQQIRQADRIRIIIMCMHSALIGGETQ 259

  Fly   288 NDFYHLGTSRTAENFMSIQIHNDVSIL--------YADLVNYTQL------TTTLTVEKLVKVLH 338
            ..|..|.......:...:.:..||.:.        |..|.|..:|      ..|:|||...|..:
Mouse   260 THFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAVLTITVESHEKTFY 324

  Fly   339 DLYARFDLAALSFKVQRIKFLGDCYYCVAGLGE--SDPDHATMAVSLG-----ISMIANIKEVSV 396
            :.||.                      .|..||  ..||...::...|     |..||
Mouse   325 EAYAE----------------------AAARGEIPEKPDSNQVSPLFGTIYNSIYFIA------- 360

  Fly   397 NRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEE 461
             :::|..|:   .:|...|..:.:.......:|.:..|.:.....|...||      :...|.:|
Mouse   361 -QAMNNAMK---KNGRASAASLVQHSRNMQFYGFNQLIKTDSNGNGISEYV------ILDTNGKE 415

  Fly   462 YNI---------------------YPG---TESAQK-------------DPVLQKHPMSTY-LLT 488
            :.:                     :||   |.:..|             ||.|..  |..: ||.
Mouse   416 WELRGTYTVDMETELLRFRGTPIHFPGGRPTSADAKCWFAERKICQGGIDPALAM--MVCFALLI 478

  Fly   489 AIPSLDS--------DKTISIVEGVPNLDLQTV----------GSNRKS------QILKPNLLSH 529
            |:.|::.        ...|.:::| ||..|.|:          ||.|.|      ||:.......
Mouse   479 ALLSINGFAYFIRRRINKIQLIKG-PNRILLTLEDVTFINPHFGSKRGSRASVSFQIISEVQSGR 542

  Fly   530 EMREEF-------------------------RKMPVGGF------------KFQFPWSRRERNLK 557
            ..|..|                         :|.|.|.|            .|:.     .::|:
Mouse   543 SPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEM-----MKDLR 602

  Fly   558 NEKVE------RDLGIFCVAFK---DKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSD 613
            :|.|.      .|.|:|.:..:   .:|:|       |.:....|.|.|
Mouse   603 HENVNPLLGFFYDSGMFAIVSEFCSRRSLE-------DILTNDDVKLDW---------------- 644

  Fly   614 IFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNEHRSY--GKL---SCAIFHLFEKIQHSFV 673
            :|.:.:::::|              |.:.:.|     ||.:  |:|   :|.       :...||
Mouse   645 MFKSSLLLDLI--------------KGMKYLH-----HREFIHGRLKSRNCV-------VDGRFV 683

  Fly   674 LRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNM-------- 730
            |::|.|     .:..::.::.:| |::..|.:::                 |....:
Mouse   684 LKVTDY-----GFNDILEMLRLS-EEEPSEEELL-----------------WTAPELLRAPGGIR 725

  Fly   731 MALILGMSYTFARI---------PFALKTFIGCAEAV--------VFVLVVCFQYAFIFEHSVTT 778
            :....|..|:||.|         ||.:.. :...|.:        |:..||..:||
Mouse   726 LGSFAGDVYSFAIIMQEVMVRGAPFCMMD-LPAKEIIDRLKMPPPVYRPVVSPEYA--------- 780

  Fly   779 SPYLKAEIAHSCRVCMMLITM---YAKERQSEFNTKMN-----------------------YKLN 817
                .||       |:.|:..   .|.|::..|:...|                       |..|
Mouse   781 ----PAE-------CLQLMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSN 834

  Fly   818 LD--LQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNF-- 877
            |:  ::.:.:..::..|....||..:||..|.|    |:.|. .:..|.:.:|::.|:.:..|
Mouse   835 LEDLIRERTEELEIEKQKTEKLLTQMLPLSVAE----SLKKGCTVEPEGFDLVTLYFSDIVGFTT 895

  Fly   878 --QMDLP--SLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFG 938
              .|..|  .:.:|||:.|.||.::.::..|    |::.:|..||.|.||
Mouse   896 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVY----KVETIGDAYMVASGL--------------- 941

  Fly   939 STSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRI 1003
                               .::|....|..:|..:||::..:......:..|...|      |||
Mouse   942 -------------------PKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVR------IRI 981

  Fly  1004 GISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETA---QTLEE-FDVMCYYR 1064
            |:.:|.::|||||.:.|.|.::|:.||.|||||||||...|.|:..|.   |||.| ::|  ..|
Mouse   982 GLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEV--ELR 1044

  Fly  1065 GLTFVKGRGEIPTYFV----GIDKDL 1086
            |.|.:||:|...|:::    |..|.|
Mouse  1045 GRTELKGKGTEETFWLVGKKGFTKPL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	14/67 (21%)
		CYCc	262..464	CDD:214485	43/247 (17%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	43/241 (18%)
		CYCc	831..1055	CDD:214485	65/233 (28%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	66/230 (29%)
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	49/278 (18%)
		PKc_like	545..815	CDD:419665	58/367 (16%)
		HNOBA	<824..869	CDD:400168	10/48 (21%)
		CYCc	848..1040	CDD:214485	67/239 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810