DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Phlpp2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	431	Identity:	78/431 - (18%)
Similarity:	153/431 - (35%)	Gaps:	137/431 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 IILCYYMVISLILMSCEKDQYELDIIESKLYN-----YDMDPFTCFHPWAYTNMMALI-LGMSYT 740
            ::||....::.:.:|| ...::|.....||.|     .|.:..|.. |....|:..|. ||:|:.
Mouse   348 VLLCEISTLTELSLSC-NGFHDLPSQIGKLLNLQTLSLDGNGLTAL-PDELGNLRQLTSLGISFN 410

  Fly   741 -FARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMM-----LITM 799
             |..||..|:                                   ::....:|.|.     ::.:
Mouse   411 DFRHIPEVLE-----------------------------------KLTMLDKVAMAGNRLEVLNL 440

  Fly   800 YAKERQSE---FNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAK-HELY 860
            .|..|.|:   .:.:||:...:..:|.:.:..:|:.       ::..:.:.::.|||:.. .:|:
Mouse   441 GALTRMSQVKHVDLRMNHLKTVITENMEGNKHITHM-------DLRDNQLTDLDLSSLCSLEQLH 498

  Fly   861 YENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKI-------KVVGCTYM 918
            .|..::..:   .|:.|     |||.|   ..:::| |:|...|.|...:       .::.|...
Mouse   499 CERNQLREL---TLSGF-----SLRTL---YASWNR-LTAVNVYPVPSLLTSLELSQNLLECVPD 551

  Fly   919 AACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEK----NHDEVAFIMATFALDLMRV 979
            .||  :...:|.||.:.|.        |.:|..|:.||:..:    .|:.:..:.|......:.|
Mouse   552 WAC--EAKKLEILDISHNL--------LTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEV 606

  Fly   980 LSVCNKAYAGEP---FDRALS------------------TGE----------IRIGISTGQIMAG 1013
            |.:.:...:..|   |.:||:                  .||          :...:.|.|.:..
Mouse   607 LDIQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPV 671

  Fly  1014 VVGASQPHYDIW-----------GNPVNMASRMESTGLSGH 1043
            :||  .||..:.           .:.:|...::|...|||:
Mouse   672 LVG--HPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGN 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485
		Nucleotidyl_cyc_III	306..489	CDD:299850
		CYCc	831..1055	CDD:214485	49/267 (18%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	46/238 (19%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131
		leucine-rich repeat	285..305	CDD:275380
		leucine-rich repeat	306..332	CDD:275380
		LRR_RI	309..548	CDD:238064	45/255 (18%)
		LRR_8	354..412	CDD:290566	14/59 (24%)
		leucine-rich repeat	356..378	CDD:275380	5/22 (23%)
		leucine-rich repeat	379..401	CDD:275380	4/22 (18%)
		leucine-rich repeat	402..424	CDD:275380	8/56 (14%)
		LRR_8	425..483	CDD:290566	9/64 (14%)
		leucine-rich repeat	425..448	CDD:275380	4/22 (18%)
		LRR_RI	447..714	CDD:238064	54/295 (18%)
		leucine-rich repeat	449..472	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..493	CDD:275380	4/25 (16%)
		leucine-rich repeat	494..513	CDD:275380	4/26 (15%)
		leucine-rich repeat	514..535	CDD:275380	8/24 (33%)
		LRR_8	536..592	CDD:290566	13/65 (20%)
		leucine-rich repeat	536..558	CDD:275380	3/23 (13%)
		leucine-rich repeat	559..581	CDD:275380	9/29 (31%)
		leucine-rich repeat	582..597	CDD:275380	1/14 (7%)
		LRR_8	604..664	CDD:290566	8/59 (14%)
		leucine-rich repeat	604..627	CDD:275380	5/22 (23%)
		leucine-rich repeat	628..653	CDD:275380	2/24 (8%)
		leucine-rich repeat	654..677	CDD:275380	4/24 (17%)
		LRR_8	676..735	CDD:290566	7/35 (20%)
		leucine-rich repeat	678..701	CDD:275380	1/22 (5%)
		leucine-rich repeat	702..724	CDD:275380	4/9 (44%)
		leucine-rich repeat	747..768	CDD:275380
		PP2Cc	816..1065	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900