DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	542	Identity:	110/542 - (20%)
Similarity:	209/542 - (38%)	Gaps:	135/542 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ERLWEQSYLKARCKELHLE-EEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYI 88
            ||||.:..:.......|:. :|.::.|...:  ::..:||.::.....|.       ||...::.
Mouse   373 ERLWIEEEVFCNAFPFHVVFDEALRVKQAGV--NIQKYVPGILTQKFGLD-------EYFSIVHP 428

  Fly    89 NAIFDLGSLILVTGLLSINFFEDFVIRHR-------WVMTFTSTLSAYVVVLGDIAFNTYYYYKS 146
            ...|::.|:...     ||  ..|:::.|       |....|..|...::.:..:.
Mouse   429 QVTFNISSICKF-----IN--SQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLK--------- 477

  Fly   147 NWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVS 211
                         ||::|..|    |..:|..:..|.      :|......|:..:     |::
Mouse   478 -------------CMVFMCSP----KLRSLQELEESK------MHLSDIAPHDTTR-----DLI- 513

  Fly   212 IDFFHYLGFNMMGIFFRIMND----TMVRSSFLDRYQFITEEI-----WLRQARRQESLLLDSIL 267
                             ::|.    .|..|..|::.:   ||:     .|...:::...||.::|
Mouse   514 -----------------LLNQQRLAEMELSCQLEKKK---EELRVLSNHLAIEKKKTETLLYAML 558

  Fly   268 PPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEK 332
            |..:|..:::                |....|..|      ...:||::|:|.:|.:.......:
Mouse   559 PEHVANQLKE----------------GKKVAAGEF------ETCTILFSDVVTFTNICAACEPIQ 601

  Fly   333 LVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVN 397
            :|.:|:.:|::||.......|.:::.:||.|..|.|:......||....:..:.|..:.|||
Mouse   602 IVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEV--- 663

  Fly   398 RSLN------IGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSS 456
              :|      |.:|:|:|:|.:.|||:|....:|.::|..||.|||:|:.|.|..||:|.....:
Mouse   664 --MNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRA 726

  Fly   457 LNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQI 521
            |..:.:.|....|...|.    |..|:||.|  |.:|::.: :.|:.....|......|..::|:
Mouse   727 LENKGFEIVTRGEIEVKG----KGKMTTYFL--IRNLNATE-VEIMGRPSALADGKEASTPRNQV 784

  Fly   522 LKPNL----LSHEMREEFRKMP 539
            .||..    :.|..::.:...|
Mouse   785 KKPRAVLSNMDHHQQQVYNSDP 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	38/265 (14%)
		CYCc	262..464	CDD:214485	54/207 (26%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	54/188 (29%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	39/259 (15%)
		Guanylate_cyc	572..754	CDD:306677	56/198 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810