DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and PHLPP2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	494	Identity:	97/494 - (19%)
Similarity:	166/494 - (33%)	Gaps:	152/494 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 CEKDQYELD-IIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVF 760
            |..|:  || |:.|.:||..... |..|.||  ..:.::.|.....:.:.       .|....:.
Human   143 CHMDR--LDRILLSGIYNVRKGK-TQLHKWA--ERLVVLCGTCLIVSSVK-------DCQTGKMH 195

  Fly   761 VL---------VVCFQYAFIFEHS-----------VTTSPYLK----AEIAHSCRVCMMLITMYA 801
            :|         |...||:..|..:           .|.:.|.:    |....|.|:..:.::.|:
Human   196 ILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYS 260

  Fly   802 KER------QSEFNTKMNYKLN---------LDLQNKQKSADVTNQS------IIILLNNILPSH 845
            .|.      .|:..|.:|.:.|         ||...|.......|.|      ..|||..|  |.
Human   261 LEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEI--ST 323

  Fly   846 VVEVYLSSIAKHELYYE-----NYRMVSVMFAMLTNFQMDLPSLRVLNDI---ITAFDRLLSAYK 902
            :.|:.||....|:|..:     |.:.:.:....||....:|.:|:.|:.:   ...|.::...|:
Human   324 LTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYE 388

  Fly   903 QYYVVEKIKVVG-CTYMAACG-----------------LDFSLIENLDSNSNFGSTSLSS----- 944
            :..:::::.:.| |..:...|                 |...:||||:.|.:.....|..
Human   389 KLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTD 453

  Fly   945 -------ELEQV---RSRL----------------ESSIKEKNHDEVAFIMATFALDLMRVLSVC 983
                   .|||:   |::|                .:.:...|...|..:: || |||.|.|..|
Human   454 LDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLL-TF-LDLSRNLLEC 516

  Fly   984 NKAYAGEP-----FD---RALSTGEIRI--GISTGQIMAGVVGASQPHYDIWGNPV--------- 1029
            ...:|.|.     .|   ..|:...:||  .:|..::|.|       |..:...|.
Human   517 VPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLG-------HNHVQNLPTLVEHIPLEV 574

  Fly  1030 -----NMASRMESTGLSG--HIQVTKETAQTLEEFDVMC 1061
                 |..:|:..|..|.  :::....:|.:||.....|
Human   575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSAC 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485
		Nucleotidyl_cyc_III	306..489	CDD:299850
		CYCc	831..1055	CDD:214485	61/312 (20%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	53/286 (19%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	18/103 (17%)
		LRR 1	250..271		3/20 (15%)
		leucine-rich repeat	253..273	CDD:275380	3/19 (16%)
		LRR 2	273..296		5/22 (23%)
		leucine-rich repeat	274..300	CDD:275380	6/25 (24%)
		LRR 3	300..321		5/20 (25%)
		leucine-rich repeat	301..323	CDD:275380	6/23 (26%)
		LRR_RI	313..606	CDD:238064	59/303 (19%)
		LRR_8	322..380	CDD:290566	12/57 (21%)
		LRR 4	323..344		5/20 (25%)
		leucine-rich repeat	324..346	CDD:275380	5/21 (24%)
		LRR 5	346..368		4/21 (19%)
		leucine-rich repeat	347..369	CDD:275380	4/21 (19%)
		LRR 6	369..390		3/20 (15%)
		leucine-rich repeat	370..416	CDD:275380	6/45 (13%)
		LRR 7	392..412		3/19 (16%)
		LRR 8	416..439		5/22 (23%)
		leucine-rich repeat	418..440	CDD:275380	6/21 (29%)
		LRR 9	440..460		1/19 (5%)
		leucine-rich repeat	442..461	CDD:275380	1/18 (6%)
		LRR 10	461..480		5/18 (28%)
		leucine-rich repeat	462..481	CDD:275380	5/18 (28%)
		LRR 11	481..502		2/20 (10%)
		leucine-rich repeat	482..503	CDD:275380	2/20 (10%)
		LRR 12	503..524		9/22 (41%)
		leucine-rich repeat	504..526	CDD:275380	10/23 (43%)
		LRR 13	526..547		4/20 (20%)
		leucine-rich repeat	527..549	CDD:275380	4/21 (19%)
		LRR_8	549..606	CDD:290566	10/63 (16%)
		LRR 14	549..570		5/27 (19%)
		leucine-rich repeat	550..565	CDD:275380	3/21 (14%)
		LRR 15	571..592		3/20 (15%)
		leucine-rich repeat	572..595	CDD:275380	4/22 (18%)
		LRR 16	595..616		4/19 (21%)
		leucine-rich repeat	596..645	CDD:275380	4/18 (22%)
		LRR 17	621..644
		LRR_8	645..703	CDD:290566
		LRR_4	645..685	CDD:289563
		LRR 18	645..666
		leucine-rich repeat	646..669	CDD:275380
		LRR 19	669..690
		leucine-rich repeat	670..692	CDD:275380
		LRR 20	692..713
		leucine-rich repeat	693..714	CDD:275380
		LRR 21	714..735
		leucine-rich repeat	715..734	CDD:275380
		LRR 22	737..758
		leucine-rich repeat	738..764	CDD:275380
		PP2Cc	784..1033	CDD:238083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900