DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Npr2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	237	Identity:	66/237 - (27%)
Similarity:	124/237 - (52%)	Gaps:	30/237 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 IMNDTMVR-SSFLDRYQFITEE---IWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDND 289
            |:::.::| ..:.:..:.:.||   .:|.:.|:.|:||. .|||..:|:.:::
Mouse   797 ILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLY-QILPHSVAEQLKR------------ 848

  Fly   290 FYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQ 354
                |.:..||.|      :.|:|.::|:|.:|.|:...|..::|.:|:|||..||....:|.|.
Mouse   849 ----GETVQAEAF------DSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVY 903

  Fly   355 RIKFLGDCYYCVAGL-GESDPDHATMAVSLGISMIANIKEVSVNRSLN--IGMRIGVHSGTLFAG 416
            :::.:||.|..|:|| |.:...||.....:.::::..:....:....:  :.:|||||:|.:.||
Mouse   904 KVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAG 968

  Fly   417 VIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLN 458
            |:|....:|.::|..||.|||:|:.|....:|||..|..:|:
Mouse   969 VVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	13/65 (20%)
		CYCc	262..464	CDD:214485	58/200 (29%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	49/156 (31%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944
		HNOBA	<798..846	CDD:369471	12/48 (25%)
		CYCc	825..1009	CDD:214485	60/206 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900