DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXA and Adcy5

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_001012783.3 Gene:Adcy5 / 224129 MGIID:99673 Length:1262 Species:Mus musculus


Alignment Length:1166 Identity:300/1166 - (25%)
Similarity:508/1166 - (43%) Gaps:264/1166 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYI-YINAIFDLGSLILVTGLL- 104
            ||..|.:|..||..||||:.  |.:|::|.|.::.:........| |:..:.....:||:..:| 
Mouse   227 LERLYQRYFFRLNQSSLTML--MAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVLC 289

  Fly   105 -SINFFEDFVIRHRWVMTFTSTLSAYVV---VLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMF 165
             ...|.:|    |..:..:  .|.|.|:   |:|.:........:..|     :.||.:..||..
Mouse   290 NRAAFHQD----HMGLACY--ALIAVVLAVQVVGLLLPQPRSASEGIW-----WTVFFIYTIYTL 343

  Fly   166 LPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIM 230
            ||: ..:||.|..:.:|..::...:|..:.::..:.:.|..:.|.|..       |::|:.....
Mouse   344 LPV-RMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCT-------NIVGVCTHYP 400

  Fly   231 NDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGT 295
            .:...|.:|.:..:.|...:..::..:|:..||.|:||..:|..::..|..|  |.|..|:.:  
Mouse   401 AEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK--QEDMMFHKI-- 461

  Fly   296 SRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLG 360
                    .||.|::||||:||:..:|.|.:..|.::||..|::|:||||..|......|||.||
Mouse   462 --------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 518

  Fly   361 DCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQY 425
            ||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:|:|||.:..||:|..|.|:
Mouse   519 DCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQF 583

  Fly   426 DIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTA- 489
            |:|..||.:|:.:||.|..|.:|::..||:.||. :|.:.||. ...::..|::|.:.|:|:.: 
Mouse   584 DVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEVEPGC-GGDRNAYLKEHSIETFLILSC 646

  Fly   490 ----------IPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFK 544
                      |..::..:|.||....|:...:....|.    |..|.:|.||:.         ..
Mouse   647 TQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH----LGGNQVSKEMKR---------MG 698

  Fly   545 FQFPWSRRERNLKN--EKVERDLG-----------------IFCVAFKDKSVEWNYLHQPDYIFK 590
            |:.|..:..:...|  ::|:..||                 .|.:.|::..:|..|..|.|..| 
Mouse   699 FEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRF- 762

  Fly   591 YSVALGWGIGC--------CLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSG 647
                 |..:.|        |.:.|..|.:|        :.:::|::..|||              
Mouse   763 -----GAYVACASLVFLFICFVQITIVPHS--------LFMLSFYLSCFLL-------------- 800

  Fly   648 QNEHRSYGKLSCAIF----------------HLFEKIQHS---------FVLRLTVYMMIILCYY 687
                     |:..:|                .|..||..|         |.:.| |::...:..:
Mouse   801 ---------LALVVFVSVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITL-VFLSAFVNMF 855

  Fly   688 MVISLILMSCEKDQYELDI-------IESKLYNYDM----------DPFTCFHPWAYTNMMALIL 735
            |..|..|:.|..:::.:.:       :....:||.:          .| .|..|..:|..:.|.|
Mouse   856 MCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQP-NCNFPEYFTYSVLLSL 919

  Fly   736 GMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEI-------------- 786
            .....|.:        |.|...:|.:|.:.|.|..|.|....|. :..|::              
Mouse   920 LACSVFLQ--------ISCIGKLVLMLAIEFIYVLIVEVPGVTL-FDNADLLVTANAIDFSNNGT 975

  Fly   787 ----AHSCRVCMMLIT----------MYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIIL 837
                .|:.:|.:.::|          :|...:|.|...::::...|....:::..:........|
Mouse   976 SQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 1040

  Fly   838 LNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------LRVLNDII 891
            |:||||..|...:|:...:: ||||::...|:||||.:.||.   ::|.:       ||:||:||
Mouse  1041 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEII 1105

  Fly   892 TAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESS 956
            ..||.::|. .::..:||||.:|.|||||.||:.|..:..      |.|.:.:            
Mouse  1106 ADFDEIISE-DRFRQLEKIKTIGSTYMAASGLNDSTYDKA------GKTHIKA------------ 1151

  Fly   957 IKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPH 1021
                        :|.||:.||..:...|        :.:.:..:::||::.|.::|||:||.:|.
Mouse  1152 ------------IADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQ 1196

  Fly  1022 YDIWGNPVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            ||||||.||:||||:|||:...||||.:..|.|  ..:.:.|  ||:..|||:||:.|||:
Mouse  1197 YDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 58/254 (23%)
CYCc 262..464 CDD:214485 82/201 (41%)
Nucleotidyl_cyc_III 306..489 CDD:299850 76/182 (42%)
CYCc 831..1055 CDD:214485 80/236 (34%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 81/232 (35%)
Adcy5NP_001012783.3 AC_N 1..459 CDD:292831 58/254 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..194
CYCc 425..620 CDD:214485 82/207 (40%)
Guanylate_cyc 461..622 CDD:278633 71/171 (42%)
DUF1053 669..761 CDD:283888 19/104 (18%)
CYCc 1037..1238 CDD:214485 80/239 (33%)
Guanylate_cyc 1063..1257 CDD:278633 82/234 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4862
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.860

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