DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and gcy-23

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	268	Identity:	66/268 - (24%)
Similarity:	134/268 - (50%)	Gaps:	41/268 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 DTMVRSSFLDRYQFITEEI------WLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDF 290
            |.|:|  .:::|....|::      .|.:|..:...||..:||..:|..::
Worm   816 DQMMR--MMEQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELK-------------- 864

  Fly   291 YHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQR 355
              :|.|..|:.|      :..:::::|:|.:|.:.::.|..::|.:|:.:|::||.|.......:
Worm   865 --MGRSVPAKTF------DMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYK 921

  Fly   356 IKFLGDCYYCVAGLGESD-PDHATMAVSLGISMIANIK--EVSVNRSLNIGMRIGVHSGTLFAGV 417
            ::.:||.|..|:|:.|.: .:|.....:..:.::..:|  |:...|::.:.:|:|:|:||:.|||
Worm   922 VETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGV 986

  Fly   418 IGKAKLQYDIWGADVNIASRLEATGSPGYVHVS--GRTLSSLNAEEYNI-YPGTESAQKDPVLQK 479
            :|....:|.::|..||:|||:|:|..|..:.:|  .|........|:.| ..||..|:     .|
Worm   987 VGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLRGTVEAK-----GK 1046

  Fly   480 HPMSTYLL 487
            .|:::|.|
Worm  1047 GPVTSYWL 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	12/64 (19%)
		CYCc	262..464	CDD:214485	51/206 (25%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	50/188 (27%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894
		HNOBA	<817..863	CDD:285003	11/47 (23%)
		CYCc	842..1035	CDD:214485	52/214 (24%)
		Guanylate_cyc	869..1056	CDD:278633	52/197 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900