DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and gcy-3

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	64/234 - (27%)
Similarity:	120/234 - (51%)	Gaps:	31/234 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 NMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQ 285
            |:|...|.::.:  ..|:.....:..|:|:.|.  :::..|||..:||.|:|:.::..   :.::
Worm   832 NLMDHVFNMLEE--YTSTLEVEVEERTKELTLE--KKKADLLLSRMLPKQVAERLKAG---QTVE 889

  Fly   286 PDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALS 350
            |             |.|      :.|::.::|:|.:|.|.:..|..::|.:|:|||:.||.....
Worm   890 P-------------EGF------DSVTVFFSDVVKFTILASKCTPFQVVNLLNDLYSNFDTIIEE 935

  Fly   351 FKVQRIKFLGDCYYCVAGLGESDP-DHATMAVSLGISMI---ANIKEVSVNRSLNIGMRIGVHSG 411
            ..|.:::.:||.|.||:||...:. :|....|.:.:..:   .|.|...:.|. .:.:||||:||
Worm   936 HGVYKVESIGDGYLCVSGLPTRNGFNHIKQIVDMSLKFMDYCKNFKIPHLPRE-RVELRIGVNSG 999

  Fly   412 TLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVS 450
            ...|||:|.:..:|.::|..||.|||:|:.|.|..:|::
Worm  1000 PCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLT 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	15/69 (22%)
		CYCc	262..464	CDD:214485	56/193 (29%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	47/149 (32%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347
		ANF_receptor	54..433	CDD:279440
		PKc_like	554..823	CDD:304357
		HNOBA	<839..882	CDD:285003	11/46 (24%)
		CYCc	861..1051	CDD:214485	58/203 (29%)
		Guanylate_cyc	888..1076	CDD:278633	50/171 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810