Protein Alignment ACXA and acy-2

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_504553.1
• Gene: acy-2 / 191607
• WormBaseID: WBGene00000069
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1162
• Identity: 307/1162 - (26%)
• Similarity: 506/1162 - (43%)
• Gaps: 260/1162 - (22%)

  Fly    31 SYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLG 95
            :||...|..:.:.:......:.|:..||.|.:| ....|:.|.|:|:...|   .|:.|   :..
 Worm    91 AYLILTCFAIRIRQPKEGMGLVLVSLSLCVLLP-AFSWILHLPVVIFVSRE---RIHTN---EHD 148

  Fly    96 SLILVTGLLSINFFEDFVI-RHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVL 159
            ...|.|.|...:..:.|:: |||.:.        :||.:..|..|.......||....:..:|:.
 Worm   149 HSALYTSLCIASVIQFFILPRHRRIF--------FVVAVSWIVANFLLIVAINWDALNVNTLFMC 205

  Fly   160 CMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMG 224
            ..:.:||   .....||:.:.....        .|.|...:|
 Worm   206 SCLSLFL---HQGVIALVGVVADSN--------EAGNRAEIA----------------------- 236

  Fly   225 IFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDND 289
               |.:.:.:.|.:.|:..:           .|||.||| |::|..:|..:.||    |||..:.
 Worm   237 ---RKLTEAVYRRTELETLK-----------DRQEQLLL-SVIPAYLADQVSKS----IIQSSST 282

  Fly   290 FYHLGTSRTAEN---------FMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFD 345
            ...:...||.:|         .:.:|:|::||||:||:||:|.|...||.:.||:.|::||::||
 Worm   283 GSTVEVPRTGKNNTKNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFD 347

  Fly   346 LAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHS 410
            ..|...:..||||||||||||:|:..:.|:||.|.|.:|:.||..||:|.:...:::.||||||:
 Worm   348 RDAQRLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHT 412

  Fly   411 GTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDP 475
            |::..|::|..|.|:|||..||.:|:.:|:.|.||.||::..|...|..:    |...::...||
 Worm   413 GSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGD----YCIVDANTDDP 473

  Fly   476 VLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQI-LKPNLLSH-EMREEFRKM 538
            .:..:...||.:  :|    ||| |.:|       :|....|.|:: ..|.|.|. .|:.:..||
 Worm   474 HVVSYGQPTYHI--LP----DKT-SAIE-------RTASIYRNSRLSTSPALQSRMSMKAKVSKM 524

  Fly   539 --------PVGGF-KFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQPDYI------ 588
                    |...| |.:|..|.....:.:|...|                     |.||
 Worm   525 VEFWGAETPFANFTKKKFSASHDPALITDEIARR---------------------PTYINTIPSM 568

  Fly   589 ---------FKYSVALGWGIGCCLIYIQSVNNSDI-------------FYTGVVINIIAFFVLTF 631
                     |.::            .|.|:.|.::             ....:..|:....:|||
 Worm   569 TLIENNLTNFSFN------------NINSMFNCELPTIPASPKLLWPFSRKSITCNLSDCVLLTF 621

  Fly   632 LLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQ----HSFVLRLTVYMMIIL---CYY-- 687
                     ||...:..|      .|.|:::...:.:|    ..|...:.:.|:.:|   |.|
 Worm   622 ---------VCIPSAFAN------LLLCSLYCPSDVLQQISLQQFFTIIGLAMLSLLGRVCSYAG 671

  Fly   688 ---MVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALK 749
               .:::.:|.||......:.|.:|||..........|.|...::::::     :...|:|::.:
 Worm   672 PLITMVAFLLSSCIPIGPHIIIKKSKLEGVMAFNSLIFLPSCVSHLVSV-----FILYRLPYSHR 731

  Fly   750 TFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMML------ITMYAKERQSEF 808
            .|:..|:.|:|.:::....|:..|..|....|..:.::.|..:.::|      ||.|.::|:|
 Worm   732 CFLFFADFVIFQVLLSLFPAYGAEVYVGYMGYHLSVVSISLSLLVVLLFFIDWITNYERKRES-- 794

  Fly   809 NTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLS-SIAKHELYYENYRMVSVMFA 872
                  ..::..||:::..:.......||:.|||||.|...:|| ..|.:|||...:..|.||||
 Worm   795 ------ACHVSFQNEERDVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFA 853

  Fly   873 MLTNFQ---------MDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLI 928
            .:.||:         ..|..||:||:|:..||:|||..| :..|||||.||.|||||.||:
 Worm   854 SIPNFKDFWSEWDTNRKLECLRLLNEIVCEFDKLLSKPK-FSSVEKIKTVGSTYMAAAGLN---- 913

  Fly   929 ENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAF----IMATFALDLMRVLSVCNKAYAG 989
               :|.:::....|.   :|...:..::|:   |..:||    :|..|||.:.::|...|:
 Worm   914 ---ESEADYDDIYLE---KQNSGKYNNNIR---HGNMAFRNANLMIEFALAMSQILDALNR---- 965

  Fly   990 EPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTL 1054
                .:....|:|||:|.|.::|||:||.:|.||||||.||:||||::.|....|..|.:..:.|
 Worm   966 ----DSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHATTDMGRVL 1026

  Fly  1055 EEFDVMCYYRGLTFVKGRGE-IPTYFVGIDKDLKFMSKKIDRLS---ENPSNPDLNH 1107
            :........||...|||..| :.|:.:.:|      ||:...:|   :|.||.:..|
 Worm  1027 QTGGYRVQSRGKIRVKGVKEPMETFLIEVD------SKRNSSVSGEQQNHSNNNNCH 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	50/249 (20%)
		CYCc	262..464	CDD:214485	84/210 (40%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	76/182 (42%)
		CYCc	831..1055	CDD:214485	87/237 (37%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	83/234 (35%)
acy-2	NP_504553.1	CYCc	253..463	CDD:214485	88/229 (38%)
		Guanylate_cyc	308..459	CDD:278633	70/150 (47%)
		CYCc	817..1034	CDD:214485	87/238 (37%)
		Guanylate_cyc	840..1054	CDD:278633	83/235 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4862
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.730