DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and gcy-33

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	683	Identity:	138/683 - (20%)
Similarity:	244/683 - (35%)	Gaps:	223/683 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 DLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFK 573
            ||..|...|.|..:|.....||.           |:|.:|..|..            ..:|   |
Worm    84 DLMNVMGRRFSDFIKGLDNIHEY-----------FRFSYPKLRAP------------SFYC---K 122

  Fly   574 DKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFY-----------------TGVVI 621
            .:|.:...||   |..:.:..|.:.||      |.|..:.:||                 |.||:
Worm   123 SESEDGLILH---YRSRRTGYLSYVIG------QLVELARVFYQLDIGIQVLKKKEKGRFTFVVL 178

  Fly   622 NIIAF----------------------------FVLTFLLFICWYKKVCWWHSGQNEHRSYGKLS 658
            . |:|                            |:..|...|.:.||:....:||
Worm   179 K-ISFDNVGLGQDLKLKERVKNLNEYLPVDTKSFLQMFPFHIAFNKKLEILMAGQ---------- 232

  Fly   659 CAIFHLFEKIQHSFV----------LRLTVYMMII--LCYYMVISL--ILMSCEKD---QYELDI 706
             .:.:|...||...:          ::.|...:::  .|.:.:.||  ::...|::   |.. ||
Worm   233 -GLLNLMPNIQGLLMTDVFDLQRPCIKFTAEGIMVHQNCVFQIESLHPVVKQTEENITVQIN-DI 295

  Fly   707 IESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPF-----------ALKTFIGCAEAVVF 760
            .|.|:   .::..|             ::...|....:|:           :.:||:..|..||.
Worm   296 TEDKV---SLEKKT-------------VMDNEYGLESLPYVTLRGPITVLKSSETFLLLATCVVD 344

  Fly   761 VLVVCFQ---YAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQN 822
            .|...|:   |...|..|......:.|.|..|..:..||..   ::|:||..|:|    ..::..
Worm   345 TLDTMFKMGLYLNDFGESDCNREIIMATIQKSDTLKTMLEN---EKRRSEVLTEM----TREISE 402

  Fly   823 KQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQM------DL 881
            .:|:|..       ||..::|..|.:..:.|.:..  :.|.:..||:.|..:.:|..      ..
Worm   403 AKKTART-------LLTQMMPYEVAQTMMRSGSVD--HCEAFECVSIGFIRVCDFSKISLFIEAF 458

  Fly   882 PSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSEL 946
            ..:.:||.|.:..|.::..:..|    |::.:|.:||.:.|..:        ..::.:..:|...
Worm   459 EVVNLLNTIYSHLDSIVDTHGVY----KVETIGESYMISAGCPY--------RDDYDAEMVSDCC 511

  Fly   947 EQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIM 1011
            .::.|.:: |.:.::||.|..::                               |:.||.||.::
Worm   512 LEMVSHIK-SFEYQSHDAVKKVL-------------------------------IKCGIFTGPVV 544

  Fly  1012 AGVVGASQPHYDIWGNPVNMASRMESTGLSG-HIQVTKETAQTLEE-----FDVMCYYRGLTFVK 1070
            .||||...|.|.::|:.||.||||||:..:. .||:.:.|...:|:     |.:.  .:|..|||
Worm   545 GGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIK--PKGNVFVK 607

  Fly  1071 GRGEIPTYFVGIDKDLKFMSKKIDRLSENPSNP 1103
            |:|::..|.:         .||..|.....|:|
Worm   608 GKGDMRVYEI---------EKKKGRARYKKSDP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485
		Nucleotidyl_cyc_III	306..489	CDD:299850
		CYCc	831..1055	CDD:214485	49/230 (21%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	53/232 (23%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902	25/114 (22%)
		HNOBA	204..423	CDD:369471	49/260 (19%)
		CYCc	402..598	CDD:214485	53/248 (21%)
		COG5134	<595..744	CDD:227463	13/48 (27%)
		TDA11	<710..>898	CDD:293689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910