Protein Alignment ACXA and daf-11

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_505960.3
• Gene: daf-11 / 179605
• WormBaseID: WBGene00000907
• Length: 1077
• Species: Caenorhabditis elegans
• Alignment Length: 1035
• Identity: 199/1035 - (19%)
• Similarity: 349/1035 - (33%)
• Gaps: 286/1035 - (27%)

  Fly   162 IYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYV-------HGLDIV----SIDFF 215
            |.:|.|   |....||.:...|.....|:..|:.|.:...:|.       :.|::.    ..|..
 Worm   117 ITIFEP---SARVILLFLGNKLNDYTEFMTAMSMNNYTTEEYTPVIVISKNSLELTFPWKENDAI 178

  Fly   216 HYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIK 280
            ..| |:...|.:....|....||||..|.|.|.|              ::|:..|:
 Worm   179 AEL-FDKAIIVYNNCYDKSKISSFLSSYSFSTIE--------------ETIISLQM--------- 219

  Fly   281 EKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLY---- 341
                   .:.|||           :..:...:|....|.||.|....::...:.....:::
 Worm   220 -------YEGYHL-----------LGYYLYTAITNTTLFNYVQPEKAISSMSIPGPFGEIFINSN 266

  Fly   342 ----ARFDLAALSFKVQRIKFLGDCYYCVAGLG-----ESDPDHATMAVSL-GISMIANIKEV-- 394
                |.:|:..:...:....|       :..||     :..||.|.:...| ..|....:|:|
 Worm   267 GQRIAGYDVLVVDKSLNSNNF-------IMPLGTISTDKKCPDQACLNFVLNSTSSFEPLKDVPL 324

  Fly   395 -----SVNRSLNIGMRIGVHSGTLFAGVI-----------GKAKLQYDIWGADVNIASRLEATGS 443
                 .:.....:.:.|.|..|.|...:|           .|.:...:.|.........::.|.:
 Worm   325 CGFHGEICDQTGVIIAIAVIMGVLLMFIIILTTIRKCCNGSKGRSISNPWVIPFQDVRFIDLTNT 389

  Fly   444 PGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNL 508
            .|..|:|.::|.. |.||..                         .:.||...|.|:.|:.|..|
 Worm   390 EGSQHMSIQSLQR-NMEEKQ-------------------------RLQSLARTKHIATVDQVYVL 428

  Fly   509 -DLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGF---------KFQFPWSRRERNLKNEKV-- 561
             |...:....:...:..||| ::|:...:...:..|         .....|::..|...::.:
 Worm   429 ADKYVMRDKLRYDKIDINLL-YQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFT 492

  Fly   562 -ERDL-------GIFCVAFKD--KSVEWNYLHQPDYIFKYSVAL-------GW-----GIGCCLI 604
             ||..       |:|   .:|  |.:|  |:|.....|..::.|       .|     |.|...:
 Worm   493 KERQRGTATRFEGLF---LRDILKGLE--YIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRL 552

  Fly   605 YIQSVNNSDIF---YTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNEHR----SYGKLSCAIF 662
            .::...:..||   :|.|:.:....:      |....||:...::.:||..    .:|| .|.::
 Worm   553 LVKWKTSGQIFTEDHTPVIKSEELHY------FDPAMKKIWKNYADRNERALITPQFGK-KCDMY 610

  Fly   663 HLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAY 727
            . |..|.|..:|:..          .|..|.....|:|       :|.|.:.:.|......|
 Worm   611 S-FGVILHEIILKKK----------FVEQLFDSPREED-------DSVLIDDENDAIASRFP--- 654

  Fly   728 TNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHS-CR 791
                            :|..:...|.....::.:|..||       .||.....|..:|..: .:
 Worm   655 ----------------LPIIIPEGIEMHNDLIKMLENCF-------GSVRPDIALARKIIDTVLK 696

  Fly   792 VCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAK 856
            :...|:.:..|..     |.....||..::|:....:...:....||..:||..|.....:.||.
 Worm   697 MSGSLVDLMIKNL-----TAYTQGLNETVKNRTAELEKEQEKGDQLLMELLPKSVANDLKNGIAV 756

  Fly   857 HELYYENYRMV---SVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYM 918
            ....|||..::   .|.|..|.:....:..:.:|:.:...||.::|....|    |::.:|..|.
 Worm   757 DPKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGY----KMETIGDAYC 817

  Fly   919 AACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEK---NHDEVAFIMATFALDLMRVL 980
            .|.||...:                 |.:.|:|....::.::   :|.|:.....||.
 Worm   818 VAAGLPVVM-----------------EKDHVKSICMIALLQRDCLHHFEIPHRPGTFL------- 858

  Fly   981 SVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQ 1045
                               ..|.|.::|.:.|||:|...|.|..:|..|.:||:|||:|:...||
 Worm   859 -------------------NCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQ 904

  Fly  1046 VTKETAQTLEEF--DVMCYYRGLTFVKGRGEIPTYFV-GID-----KDLKFMSKKIDRLS 1097
            :|..:.|.|||.  ..:|..||...::|.|.|.||:: |::     |.::|.:...|.||
 Worm   905 MTLASQQLLEENFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGEQVKVVEFQNDLNDELS 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	27/139 (19%)
		CYCc	262..464	CDD:214485	37/233 (16%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	32/214 (15%)
		CYCc	831..1055	CDD:214485	52/229 (23%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	56/228 (25%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141	40/229 (17%)
		PKc_like	447..695	CDD:304357	53/304 (17%)
		HNOBA	<714..750	CDD:285003	8/35 (23%)
		CYCc	729..922	CDD:214485	55/239 (23%)
		Guanylate_cyc	756..943	CDD:278633	56/233 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810