Protein Alignment ACXA and acy-3

DIOPT Version :10

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1078
• Identity: 225/1078 - (20%)
• Similarity: 423/1078 - (39%)
• Gaps: 238/1078 - (22%)

  Fly    22 YTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPML--ILLIVALQVIIWSFTEYTK 84
            :::|.| |||||..|    |.....: .:|.|.|:|.:.|:..|  |....||    |:
 Worm     3 FSSEWL-EQSYLDWR----HAASARL-IRIVLFITSGSAFLRTLGHIPGFYAL----WT------ 51

  Fly    85 YIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWP 149
                       ::||:...::|.|   .::|...:..|  .:.|.:|:|.|:|| ....|:|.:|
 Worm    52 -----------AVILLLSTVTIIF---HILRPARIAAF--QILAGIVLLLDVAF-ALPGYESLFP 99

  Fly   150 LNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDF 214
              .|..||.|   |.|..:|   ..|:||.| :|..::....|:.|.|.     :|..::::|..
 Worm   100 --ALLAVFSL---YTFFSLP---FYAILATS-TLISIVQTCSFLLFVEP-----LHTNELLAIIV 150

  Fly   215 FHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSI 279
            .| :..|..||:.....|.:.|::||........|........:.:.||.|.||..:....:..|
 Worm   151 VH-IWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNKLLSSFLPYHLINQARHQI 214

  Fly   280 KEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARF 344
              .:.:|     ||..          :.::.||:.|..||.:..:....:.....:||.:|.:|.
 Worm   215 --TLYKP-----HLYN----------ETYSQVSVAYGRLVGFESVLAQCSSIDAARVLKELDSRI 262

  Fly   345 DLAALSFKVQRIKFLGDCYYC-VAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGV 408
            :..|.|....|:...|....| :.|:   |..|||......:.:...|.........::.:.||:
 Worm   263 ERLAASNGCTRVASEGITAVCSIPGI---DSQHATKLCRFSMELETLINSFRDATGADVSVCIGI 324

  Fly   409 HSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRT---LSSLNAEE-------YN 463
            .||.:.|||:|.:|..||:.|:..:.|..:::..:...|:||..|   |.|....|       :.
 Worm   325 DSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGSTGEFELEKCPIGWK 389

  Fly   464 IYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLS 528
            :|....|.:..||.::     :.|..:|...:....|||  ..|..|:|:|:|:|.:       .
 Worm   390 LYGHLPSPELFPVNKR-----FSLVTVPQAVNRVLQSIV--AMNPTLKTMGTNKKRK-------G 440

  Fly   529 HEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVA--FKDKSVEWNYLHQPDYIFKY 591
            .:.:|:|                   :::.:|||....|..::  |::..:|..|..:.|:.|..
 Worm   441 EKSQEKF-------------------DMQKKKVEHSTIISTLSQRFRNPGLEAEYHKETDHWFIP 486

  Fly   592 SVALG------WGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNE 650
            |:|:.      :||...|:..:.:       |.:.:.:.|..|:.|:|.:
 Worm   487 SLAISIFFLVVYGIYHMLVMPRLI-------TSLALIVGALTVMFFILLM--------------- 529

  Fly   651 HRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYD 715
                  |....||.|.:    |:.|.:....:.:   ::|.:||..|       .|:.:
 Worm   530 ------LYIDYFHTFSQ----FITRTSAGHAVSI---ILIIVILFVC-------GIVNT------ 568

  Fly   716 MDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSP 780
               |:|..|.| .::.......:|:||........|:......:.:|::.....:..:..||...
 Worm   569 ---FSCPQPNA-PDVCQKAHFSTYSFAMWTITTAVFVRFPSVYLAILLIISLLTYGLQIYVTRPD 629

  Fly   781 -----YLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNY----KLNLDLQNKQKSADVTNQSIII 836
                 ....|:..||.:..::..::...|:.|...::::    |...:...|.|..::.||
 Worm   630 EFGPREFMTELDLSCFLISLVSMVFLHSRRCERLLRLDFLAVVKGIEETSMKDKLINLNNQ---- 690

  Fly   837 LLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMD-LPSLRVLNDIITAFDRLLSA 900
            :|.|::|:||....:....  ::::.:::.|.:.:..::.|.:: ...:..||.:.:.||:.::.
 Worm   691 MLLNLVPAHVAPGVIQKAG--DVWHHSHQSVGIAYIAVSGFDLEGEAGINGLNYVFSHFDQAIAN 753

  Fly   901 YKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEV 965
            ||.   |||:|.....|:.|.||      ..|:..|...|..:                     :
 Worm   754 YKG---VEKVKSANRFYIVAVGL------LPDAAQNVNETPWT---------------------I 788

  Fly   966 AFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVN 1030
            ..:|:|.|   ..::|:...|...|        ..::||:..|..:|.|....||.|:|:|..::
 Worm   789 GELMSTLA---HFIISISQFAMENE--------FHVQIGVDCGSTLAFVANTDQPRYEIFGETLD 842

  Fly  1031 MASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTF 1068
            .:..:...  :||     :|....||..:....|.|.|
 Worm   843 RSRTLMQA--AGH-----DTTLVSEEVFLALRPRPLRF 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AcyC	88..457	CDD:441717	88/372 (24%)
		Nucleotidyl_cyc_III	306..489	CDD:448371	45/193 (23%)
		Nucleotidyl_cyc_III	859..1080	CDD:448371	43/211 (20%)
acy-3	NP_497765.4	AcyC	6..380	CDD:441717	108/441 (24%)
		Nucleotidyl_cyc_III	221..382	CDD:448371	41/173 (24%)
		CYCc	696..873	CDD:214485	45/226 (20%)