Protein Alignment ACXA and gcy-29

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_001364597.1
• Gene: gcy-29 / 175116
• WormBaseID: WBGene00007314
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1085
• Identity: 204/1085 - (18%)
• Similarity: 342/1085 - (31%)
• Gaps: 453/1085 - (41%)

  Fly   208 DIVSIDFFHYLGFN---MMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSIL-- 267
            |:|...:.:.|..|   ::.||          ||..|.........||......|.:.::.::
 Worm   207 DLVDNGYMNELRDNARVILPIF----------SSTRDLSTVFRNATWLANMASPEFIYINPLIVA 261

  Fly   268 -----PPQI-AKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHND---------------- 310
                 ||.. .|..|||||                  |||..:|||:|.
 Worm   262 RNSEEPPVFYGKMAQKSIK------------------AENPNTIQIYNSYGFSDDLLNEFLAIFD 308

  Fly   311 ----VSILYADLVNYTQLTTTLTV-EKLV-KVLHDL-------YARFDLAALSFKVQRIKFLG-- 360
                :.|...||.||..|..:..| .||. |.||.|       ..|.|..||......:.|.|
 Worm   309 QNQRIYIDEKDLFNYVALYESFCVFAKLTEKYLHSLKEKPEDGKIRIDGKALWNMAVGMTFQGVL 373

  Fly   361 ---------------DCYY---------------------------CV----------------A 367
                           ..:|                           |:                .
 Worm   374 DNVIFDNGAERMTSFSAFYVDEKRDQIRTVSLINSTVTSKNCMDPVCIELVVSDVVTKFWSSPSG 438

  Fly   368 GLGESDPD--------HATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQ 424
            .|.:|:|:        ..|..:.:..:::..|..|    .|.|.:|....:..|       .|:.
 Worm   439 KLPDSEPECGFREENCDYTQTIVIATAVVCIILTV----FLGIWLRRACETSAL-------DKMP 492

  Fly   425 YDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTA 489
            :.::..||.|....:.           :::.|||:      ..|:.:|.:..|.|:       .|
 Worm   493 WRVFRDDVQILDEEQV-----------KSVVSLNS------ASTKMSQVETKLIKN-------HA 533

  Fly   490 IPSLDSDKTISIVEGVPNLDLQTVGSNRKSQIL--KPNLLSHEMREEFRKMPVGGFKFQFPWSRR 552
            |..:::.....:.|     ..|.:...|:..||  |.....|:     ...|..|..|
 Worm   534 IVGVNTHAVYDLYE-----QRQNIRFTREDLILLTKMKQAVHD-----NINPFIGVSF------- 581

  Fly   553 ERNLKNEKVE-------------RDLGIFCVAF-----------KDKSVEWNYLHQPDYIFKYSV 593
                 |||.|             :|: |:|..|           :|.::...|||        |.
 Worm   582 -----NEKSELLLLWKFCSRGTLQDV-IYCEKFAMDEKFQGAFVRDITMGLEYLH--------SS 632

  Fly   594 ALGW--GIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVC-----WWHSGQNEH 651
            .:|:  |:.|..:.|..                     .::|.:..| .||     |
 Worm   633 PIGYHGGLACWSVLIDK---------------------NWMLKLTDY-AVCDPLKRW-------- 667

  Fly   652 RSYGKLSCAIFH-----------------------------LFEKIQHSFVLR---LTVYMMIIL 684
            ..:|:::|.:.:                             :.:|.|...:|:   ..:|...::
 Worm   668 EKHGRINCKVDNEAEKQWQKMASLYVPPEIRTANEKNRLKRMDQKWQGQTILKRQQSDIYAFGVI 732

  Fly   685 CYYMVI------------SLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALIL-- 735
            .|.::.            .|...:.|.|:.:...|:.   |..::|          :::||:.
 Worm   733 IYEILFRSLPYDEKVDLTELAQKAAEGDKIQKPSIQR---NKKLNP----------DLIALLQDC 784

  Fly   736 -----GMSYTFARI----PFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCR 791
                 .|..|..|:    ..||||                                |..:..|
 Worm   785 WSDQPDMRPTIRRVRLATEIALKT--------------------------------KGNLVDS-- 815

  Fly   792 VCMMLITMYAKERQSEFNTKMNYKLNLD--LQNKQKSADVTNQSIIILLNNILPSHV-VEVYLSS 853
             .|.::..||.              ||:  :..:.|.|:..|.....||..:||.|| :|:....
 Worm   816 -MMRMMEEYAN--------------NLEKLVGERTKLAEEANLRAERLLFQLLPKHVAIELKAGR 865

  Fly   854 IAKHELYYENYRMVS--VMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCT 916
            ....::|.....|.|  |.|..|.:....:..:.:||.:.:.||.::|.:..|    |::.:|..
 Worm   866 TVAPKMYDSATVMFSDIVGFTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCY----KVETIGDA 926

  Fly   917 YMAACGLDFSLIENLDSN-SNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVL 980
            ||...|:.   |||...: :|..:.:|.                             .:||::|.
 Worm   927 YMVVSGIP---IENGQRHVANISAVTLG-----------------------------IMDLLKVF 959

  Fly   981 SVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQ 1045
            .|.::.      |..|:   ||:|.::||:.|.|||.|.|.|.::|..||:|:.|||:|..|.:|
 Worm   960 EVPHRR------DYRLT---IRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRVQ 1015

  Fly  1046 VTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV---GIDKDLK 1087
            :| ||::.|.|                .|.|.:.:   ||:||:|
 Worm  1016 IT-ETSKILLE----------------NEYPEFIIEIRGINKDVK 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	20/93 (22%)
		CYCc	262..464	CDD:214485	53/306 (17%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	45/279 (16%)
		CYCc	831..1055	CDD:214485	61/227 (27%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	57/223 (26%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575	47/223 (21%)
		PKc_like	534..804	CDD:419665	51/343 (15%)
		CYCc	840..1033	CDD:214485	65/254 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900