DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and gucy2d

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	868	Identity:	170/868 - (19%)
Similarity:	300/868 - (34%)	Gaps:	307/868 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 YARFDLAALSFKVQRIKFLG-------DCYY-----CVAGLGESDPDHATM--AVSLGISMIANI 391
            |.::  ..|.:..:.|.|.|       :|::     |..||     |..|:  .:...|.:||.
Zfish   460 YGKY--GGLKYLGKSIHFAGASPSSDANCWFSPYIACSGGL-----DGVTLFFLLMFFIVLIAG- 516

  Fly   392 KEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVS------ 450
                              :|.||        ||...:||.....:.:...|||..:.::
Zfish   517 ------------------AGILF--------LQVRKYGAGGFFGAFIGGGGSPTKIVLTLDDLVF 555

  Fly   451 -GRTLS--SLNAEEYNIYPGTESAQKDPVLQKHPMS--TYLLTAIPSLDSDKTISIVEG------ 504
             ..|||  .||.|      ....:|.|....:|.:|  :| :|:.|...:   :::.||
Zfish   556 INTTLSRRKLNDE------SMLKSQLDVKTPRHSVSGRSY-ITSTPETSN---VAVFEGDWVWLK 610

  Fly   505 -VPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIF 568
             .|..|..|..|.....|.   :...:||.|...:.:|.|                   .|.|||
Zfish   611 KCPCADSITEISESTQTIF---VKLRDMRHENLNLFLGLF-------------------MDTGIF 653

  Fly   569 CVAFKD---KSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLT 630
            .:..:.   .|:|       |.:....:.|.|                :|.:.:::::|
Zfish   654 GIVTEHCTRGSLE-------DLLNNEEMRLDW----------------MFKSSLLLDLI------ 689

  Fly   631 FLLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMM--IILCYYMVISLI 693
                    :.:.:.|:....|......:|.       :...|||::|.|..  |:.|..:::.
Zfish   690 --------RGMKYLHNRGIIHGRLKSRNCV-------VDGRFVLKVTDYGFNEILNCQNIILE-- 737

  Fly   694 LMSCEKDQY----EL----DIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARI------ 744
             .:..:||:    |:    |:.:...|..|:        ::::.:|..::.....|..:
Zfish   738 -DNAPEDQFWTAPEILRNPDLKKKGTYPGDV--------YSFSIIMQEVISRCAPFCMLDMPPEE 793

  Fly   745 --------PFALKTFIGCAEAVVFVLVVCFQ-----------YAFIFEHSVTTSPYLKAEIAHSC 790
                    |...:..:...||.:.|:.:..|           :..||....:.:...|..|..|
Zfish   794 IIEKVRSPPPLCRPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFEDIFRQFKSMNKGKKTNIIDS- 857

  Fly   791 RVCMMLITMYA-------KERQSEFNTKMNYKLNLDLQNKQKS----ADVTNQSIIILLNN---I 841
              .:.::..|:       :||..|...:           :||:    |.:..:|:.:.|..   :
Zfish   858 --MLRMLEQYSSNLEDLIRERTEELEVE-----------RQKTDALLAQMLPKSVALALKTGKPV 909

  Fly   842 LPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYV 906
            .|.|..||        .||:.:.    |.|..::.....:..:.:|||:.|.||.:::.:..|
Zfish   910 KPEHFAEV--------TLYFSDI----VGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVY-- 960

  Fly   907 VEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMAT 971
              |::.:|..||.|.|                                  :..:|....|..||.
Zfish   961 --KVETIGDAYMVASG----------------------------------VPNRNGTRHAAEMAN 989

  Fly   972 FALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRME 1036
            .:||::..:......:..:      ...:||||:.:|.::|||||...|.|.::|:.||.|||||
Zfish   990 MSLDILHCIGTFKMRHMPD------VKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRME 1048

  Fly  1037 STGLSGHIQVTKETAQTLE------EFDVMCYYRGLTFVKGRGEIPTYFV----GIDKDLKFMSK 1091
            ||||...|.|.:.|...|.      :.|.    ||.|.:||:|...|:::    |.||.|
Zfish  1049 STGLPYRIHVNQSTVDVLNSLKLGYKIDT----RGRTELKGKGVEETFWLVGRDGFDKPL----- 1104

  Fly  1092 KIDRLSENPSNPDL-----NHDL 1109
                    |..|||     ||.:
Zfish  1105 --------PIPPDLTPGASNHGI 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485	30/145 (21%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	35/172 (20%)
		CYCc	831..1055	CDD:214485	56/226 (25%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	59/226 (26%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366	2/11 (18%)
		PK_GC-2D	581..849	CDD:270945	53/348 (15%)
		HNOBA	<858..903	CDD:311573	8/55 (15%)
		CYCc	883..1075	CDD:214485	60/258 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910