DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and gc2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	1267	Identity:	233/1267 - (18%)
Similarity:	412/1267 - (32%)	Gaps:	478/1267 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WEQSYLKARCKELHLEEEYMKYKIRLMISSLTVF-----VPMLILLIVALQVIIWSFTEYTKYIY 87
            |.::.....|.|..|::          :.|...|     ||.|:||         ||..:.::.:
Zfish   147 WNKAVFSWSCIEHELDD----------VRSHPTFARTMPVPSLVLL---------SFMRHFRWAH 192

  Fly    88 INAIFDLGSLILVTGLLSINFFEDFVIRHRWV---MTFTSTLSAYVVVLGDI--AFNTYYYYKSN 147
            :             |::|.:  ||.     ||   :...:.|.::.:.:|.:  |.|.:...:
Zfish   193 V-------------GIISSS--EDV-----WVEAAIKLANALRSHGLPVGIVTSARNDHTSVR-- 235

  Fly   148 WPLNTLYDV-----FVLCMIYMFLPIPSSKAAALLAISV--------SLTYVIYFIHFMAFNEHN 199
               .||..|     ..|.::.|...:...:...||..:.        ||.::.|...|.:...|:
Zfish   236 ---QTLAKVRKVADLRLVILVMHSVLIGGRTQKLLLETAHDMRMTDGSLVFMSYDTLFYSLPYHH 297

  Fly   200 V--------AKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQAR 256
            |        :|.:...|.|                ..|..::....||...::           :
Zfish   298 VTQPALRYNSKLLRAYDAV----------------LTITIESPKEQSFYQAFE-----------K 335

  Fly   257 RQESLLLDSILPPQIAKPIQKSIKEKI---------IQPDNDFYHLGT-SRTAENFM-----SIQ 306
            .||...|...|.||...|:..:|...|         ::....:...|. ::.|.|.:     |:|
Zfish   336 AQEDGELPKHLKPQQVSPLFGTIYSSIVFMAHAVQSVRAAGQWMSGGNIAQNARNLLFKGGSSLQ 400

  Fly   307 IHN------DVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLG-DCYY 364
            .::      |..||..|..:: :|..|..:|                   .:...::||| ..::
Zfish   401 ANSSDFGMLDYVILDTDGFSW-ELQPTYRIE-------------------MQTDMVRFLGRHIHF 445

  Fly   365 CVAGLGESDPD----------------HATMAVSLGISMI-----------ANIKEVSVNRSLNI 402
            ..||...:|..                |......||...|           ..|.::.:.|..|
Zfish   446 PYAGPPRTDSSCWFTHGIICRGGVNLFHMISMFLLGFLFIFLSIGCSYCIRRKINKIRLVRGPN- 509

  Fly   403 GMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPG 467
            .:.:.::..|.....:...||..|            ::..|...:.:|.|:|.|
Zfish   510 KILLTLNDVTFINPSLSNKKLSVD------------DSKASDTRMSISERSLVS----------- 551

  Fly   468 TESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMR 532
                         |||    :..|:...:..::|.||    |...:
Zfish   552 -------------PMS----SQSPATYENSNVAIYEG----DWAWM------------------- 576

  Fly   533 EEFRKMPVGGFKFQFPWS----RRERNLKNEKVERDLGIF--CVAF-------KDKSVEWNYLHQ 584
               :::|.|.|:...|.:    ...::|::|.:...||.|  |..|       ...|:|
Zfish   577 ---KRLPYGTFRSITPNTSDVFELMKDLRHENINPFLGFFHDCGVFAIVTEFCSRGSLE------ 632

  Fly   585 PDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQN 649
             |.:....|.|.|                :|.:.:::::|              |.:.:.|
Zfish   633 -DLLVNDDVKLDW----------------MFKSSLILDLI--------------KGMKYLH---- 662

  Fly   650 EHRS--YGKL---SCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIES 709
             ||:  :|:|   :|.       :...|||::|.|                     .|. :::||
Zfish   663 -HRNVCHGRLKSRNCV-------VDGRFVLKITDY---------------------GYN-EVLES 697

  Fly   710 KLYNYDMDPFTCFHPW--------AYTNMMALILGMSYTFARI---------PFAL--KTFIGCA 755
            :.:.| ::|......|        :|..:.....|..|:|:.|         ||.:  .||....
Zfish   698 QRFPY-IEPPAEDLLWTAPEILRGSYPGLHGTHSGDVYSFSIIMQEVVMRGPPFCMLENTFDEIV 761

  Fly   756 EAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNT---------- 810
            :.|.....:|             .|.:..:  |:...|:.|:.....|:..:..|
Zfish   762 QKVRKPPPMC-------------RPIVSPD--HAPMECIQLMKQCWNEQPEKRPTFDEIFDQFKN 811

  Fly   811 -----KMN-----------YKLNLD--LQNKQKSADVTNQSIIILLNNILPSHVVE-VYLSSIAK 856
                 |.|           |..||:  ::.:.:..::..|....||..:||..|.| :.|.:..:
Zfish   812 VNKGKKTNIIDSMLRMLEQYSSNLEELIRERTEELEIEKQKTEKLLTQMLPPSVAEALKLGTTVE 876

  Fly   857 HELYYENYRMVSVMFAMLTNF------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGC 915
            .    |::..||:.|:.:..|      ...:..:.:|||:.|.||.::..:..|    |::.:|.
Zfish   877 P----EHFESVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTTFDAVIGNHDVY----KVETIGD 933

  Fly   916 TYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVL 980
            .||.|.|                                  :...|.:..|..:|..|||::..:
Zfish   934 AYMVASG----------------------------------VPVPNGNRHAAEIANMALDILSAV 964

  Fly   981 SVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQ 1045
            ......:..:...|      ||||:.||..:|||||.:.|.|.::|:.|..|||||||||...|.
Zfish   965 GTFRMRHMPDVPVR------IRIGLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIH 1023

  Fly  1046 VTKETAQTLEEFDV--MCYYRGLTFVKGRGEIPTYFV------------------GID-KDLKFM 1089
            |...|.:.|.|..:  ....|..|.:||:....||::                  |:: ||.|.|
Zfish  1024 VHSSTVKILMELKLGYRVELRARTELKGKRIEETYWLTGRDGFTKPLPVPPVLKSGLESKDFKVM 1088

  Fly  1090 SKKIDR------------LSENPSNPDLNHDL 1109
            .||..|            ||:..:....:|||
Zfish  1089 LKKAVRKISTVRQVAQLTLSDEGNVMIHHHDL 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	48/288 (17%)
		CYCc	262..464	CDD:214485	41/250 (16%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	33/216 (15%)
		CYCc	831..1055	CDD:214485	60/230 (26%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	60/228 (26%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	64/383 (17%)
		PK_GC-2D	551..815	CDD:270945	63/404 (16%)
		HNOBA	<824..869	CDD:311573	10/44 (23%)
		CYCc	848..1040	CDD:214485	62/239 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810