DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Gucy2f

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_446283.1	Gene:	Gucy2f / 116556	RGDID:	620439	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1038	Identity:	211/1038 - (20%)
Similarity:	365/1038 - (35%)	Gaps:	361/1038 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 EEIWLRQARRQESLLLDSILP-------PQIAKPIQKSIKE-------KII-----------QPD 287
            |:||:..|.:..|.|....||       .|.::.|||::::       :||           :..
  Rat   195 EDIWVHTANQVSSALRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQ 259

  Fly   288 NDFYHLGTSRTAENFMSIQIHNDVSIL--------YADLVNYTQL------TTTLTVEKLVKVLH 338
            ..|..|.......:...:.:..||.:.        |..|.|..:|      ..|:|||...|.
  Rat   260 THFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKT-- 322

  Fly   339 DLYARFDLAALSFKV-------QRIKFLGDCYYCVAGLGESDPDHATMAVSL---GISMIANIKE 393
             .|..|..||...::       |.....|..|..:..:.::      |:.:|   |.:..|::..
  Rat   323 -FYEAFTEAAAGGEIPEKLDSHQVSPLFGTIYNSIYFIAQA------MSNALKENGQASAASLTR 380

  Fly   394 VSVNR---SLNIGMRIGVHSGTLFAGVI----GKAKLQYDIWGA-DVNIASR-LEATGSPGYVHV 449
            .|.|.   ..|..:|...:...:...||    ||   ::::.|. .|::.:. |...|:|  :|.
  Rat   381 HSRNMQFYGFNQLIRTDSNGNGISEYVILDTNGK---EWELRGTYTVDMETELLRFRGTP--IHF 440

  Fly   450 SGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTY-LLTAIPSLDS--------DKTISIVEGV 505
            .|...:|.:|:.:...........||.|..  |..: ||.|:.|::.        ...|.:::|
  Rat   441 PGGRPTSADAKCWFAQGKICQGGIDPALAM--MVCFALLLALLSINGFAYFIRRRINKIQLIKG- 502

  Fly   506 PNLDLQTV----------GSNRKS------QILKPNLLSHEMREEF------------------- 535
            ||..|.|:          ||.|.|      ||:.........|..|
  Rat   503 PNRILLTLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYQ 567

  Fly   536 ------RKMPVGGF------------KFQFPWSRRERNLKNEKVE------RDLGIFCVAFK--- 573
                  :|.|.|.|            .|:.     .::|::|.|.      .|.|:|.:..:
  Rat   568 GDWVWLKKFPPGDFGDIKSIKSSASDVFEM-----MKDLRHENVNPLLGFFYDSGMFAIVSEFCS 627

  Fly   574 DKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWY 638
            .:|:|       |.:.:..|.|.|                :|.:.:::::|
  Rat   628 RRSLE-------DILTQDDVKLDW----------------MFKSSLLLDLI-------------- 655

  Fly   639 KKVCWWHSGQNEHRSY--GKL---SCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCE 698
            |.:.:.|     ||.:  |:|   :|.       :...|||::|.|     .:..::.::.:| |
  Rat   656 KGMKYLH-----HREFIHGRLKSRNCV-------VDGRFVLKVTDY-----GFNNILEMLRLS-E 702

  Fly   699 KDQYELDIIESKLYNYDMDPFTCFHPWAYTNM--------MALILGMSYTFARI---------PF 746
            ::..|.:::                 |....:        :....|..|:||.|         ||
  Rat   703 EEPSEEELL-----------------WTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPF 750

  Fly   747 ALKTFIGCAEAV--------VFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKE 803
            .:.. :...|.:        |:..||..::|                 ...|...|......|.|
  Rat   751 CMMD-LSAKEVIDRLKMPPPVYRPVVSPEFA-----------------PPECLQLMKQCWAEAAE 797

  Fly   804 RQSEFNTKMN-----------------------YKLNLD--LQNKQKSADVTNQSIIILLNNILP 843
            ::..|:...|                       |..||:  ::.:.:..::..|....||..:||
  Rat   798 QRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLP 862

  Fly   844 SHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNF----QMDLP--SLRVLNDIITAFDRLLSAY 901
            ..|.|    |:.|. .:..|.:.:|::.|:.:..|    .|..|  .:.:|||:.|.||.::.::
  Rat   863 PSVAE----SLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSH 923

  Fly   902 KQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVA 966
            ..|    |::.:|..||.|.||                                  .::|....|
  Rat   924 DVY----KVETIGDAYMVASGL----------------------------------PKRNGSRHA 950

  Fly   967 FIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNM 1031
            ..:|..:||::..:......:..|...|      ||||:.||.::|||||.:.|.|.::|:.||.
  Rat   951 AEIANMSLDILSSVGTFKMRHMPEVPVR------IRIGLHTGPVVAGVVGLTMPRYCLFGDTVNT 1009

  Fly  1032 ASRMESTGLSGHIQVTKETA---QTLEE-FDVMCYYRGLTFVKGRGEIPTYFV----GIDKDL 1086
            |||||||||...|.|:..|.   :||.| ::|  ..||.|.:||:|...|:::    |..|.|
  Rat  1010 ASRMESTGLPYRIHVSLSTVTILRTLSEGYEV--ELRGRTELKGKGTEETFWLVGKKGFTKPL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	14/67 (21%)
		CYCc	262..464	CDD:214485	50/259 (19%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	45/216 (21%)
		CYCc	831..1055	CDD:214485	65/233 (28%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	66/230 (29%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	49/251 (20%)
		ANF_receptor	75..412	CDD:279440	44/225 (20%)
		PKc_like	545..815	CDD:304357	55/364 (15%)
		TyrKc	565..809	CDD:197581	53/338 (16%)
		HNOBA	<824..869	CDD:285003	10/48 (21%)
		CYCc	848..1040	CDD:214485	67/239 (28%)
		Guanylate_cyc	875..1062	CDD:278633	66/232 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810