DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and ADCY7

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_011521137.1	Gene:	ADCY7 / 113	HGNCID:	238	Length:	1086	Species:	Homo sapiens

Alignment Length:	1188	Identity:	322/1188 - (27%)
Similarity:	518/1188 - (43%)	Gaps:	283/1188 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YMKYKIRLMISSLTVFVPMLILLI-------VALQVIIWSFTEYTKYIYINAIFDLGSLIL-VTG 102
            |.||::      .:...|:|:.|:       |||.:|.:|..:.:::   .||..:..|:| |..
Human    22 YEKYQL------TSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRH---QAILGMAFLVLAVFA 77

  Fly   103 LLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDI-AFNTYYYYKSNWPLNTLYDVFVLCMIYMFL 166
            .||:..:.:.::| ||:........|.:|.||.: .|:.:......|. ...:.:|::.::|..|
Human    78 ALSVLMYVECLLR-RWLRALALLTWACLVALGYVLVFDAWTKAACAWE-QVPFFLFIVFVVYTLL 140

  Fly   167 PIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMN 231
            |.....|.|:.|:|.:...::.......|...:|..   ||.:::.......| |:.|.|.:
Human   141 PFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRV---GLQLLANAVIFLCG-NLTGAFHK--- 198

  Fly   232 DTMVRSSFLDRYQFITEEIWLR-----QARRQESLLLDSILPPQIAKPIQKSIKEKI-------I 284
             ..::.:..|.:.:..:.|.:|     :.|:||:||| |:||..|:..::.:|.|::       .
Human   199 -HQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLL-SVLPAHISMGMKLAIIERLKEHGDRRC 261

  Fly   285 QPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAAL 349
            .|||:|:.|...|          |.:|||||||:|.:|||.:..:.::||.||::|:.:||..|.
Human   262 MPDNNFHSLYVKR----------HQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAK 316

  Fly   350 SFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLF 414
            :.:..|||.||||||||:||..|.|.||...|.:|:.|...||:|.....::|.||:|:|||.:.
Human   317 ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVL 381

  Fly   415 AGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQK 479
            .||||..|.|||:|..||::|:|:||.|.||.||::..||..|: :.|.:..| ...|:||.|::
Human   382 CGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLD-KAYEVEDG-HGQQRDPYLKE 444

  Fly   480 HPMSTYLL------------TAIPSLDSDKTI----------------------------SIVEG 504
            ..:.|||:            ..:|....|..:                            |:..|
Human   445 MNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSG 509

  Fly   505 ---VPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKV----- 561
               |||      |...||           :.:..|:.|   .:...|..|.|.:..::::
Human   510 ETHVPN------GRRPKS-----------VPQRHRRTP---DRSMSPKGRSEDDSYDDEMLSAIE 554

  Fly   562 -----------ERDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF 615
                       ..|...|...|.:|..|..|...|....::..|....|..|::.:..:......
Human   555 GLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTA 619

  Fly   616 YTGVVINIIAFFVLTFLLFICW---YKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLT 677
            ..||...::| .||..:|.:|:   :.:.|         .:.|.| |.|   .|:::...:||||
Human   620 ALGVSFGLVA-CVLGLVLGLCFATKFSRCC---------PARGTL-CTI---SERVETQPLLRLT 670

  Fly   678 VYMMII--LCYYMVISLILMSCEKDQY----ELDII----ESKLYNYDMDPFTCFHPWAYTNMMA 732
            :.::.|  |....:|:|.||..:..:.    |..::    :::.....:..:||          :
Human   671 LAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTC----------S 725

  Fly   733 LILGM--SYTFARIPF----ALKTFIGCAEAVVFVLVVCFQ------------------------ 767
            .:||.  ...|.|:..    .|.|....|..|:|.|..|:|
Human   726 CVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSC 790

  Fly   768 -----------YAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQ 821
                       |..:|..::.|   |..:|.:.||:..:....:.||.: ||.|..|
Human   791 SWKDLKTMTNFYLVLFYITLLT---LSRQIDYYCRLDCLWKKKFKKEHE-EFETMEN-------- 843

  Fly   822 NKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQM------- 879
                    .|:   :||.|:||:||...::......:.|:::|..|.||||.:.:|::
Human   844 --------VNR---LLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDV 897

  Fly   880 ---DLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTS 941
               .|..||:||:||..||.||...| :..|||||.:|.|||||.||
Human   898 NKEGLECLRLLNEIIADFDELLLKPK-FSGVEKIKTIGSTYMAAAGL------------------ 943

  Fly   942 LSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGIS 1006
                  .|.|..|:...|:.|..:. :|..|::.||..|...|:        .:.::..:|:||:
Human   944 ------SVASGHENQELERQHAHIG-VMVEFSIALMSKLDGINR--------HSFNSFRLRVGIN 993

  Fly  1007 TGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHI------QVTKETAQTLEEFDVMCYYRG 1065
            .|.::|||:||.:|.||||||.||:||||||||..|.|      |||:||...|:.....|..||
Human   994 HGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRG 1058

  Fly  1066 LTFVKGRGEIPTYFVGID 1083
            |..|||:||:.||||..|
Human  1059 LINVKGKGELRTYFVCTD 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	61/265 (23%)
		CYCc	262..464	CDD:214485	88/208 (42%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	82/194 (42%)
		CYCc	831..1055	CDD:214485	85/239 (36%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	89/236 (38%)
ADCY7	XP_011521137.1	AC_N	<73..249	CDD:292831	42/186 (23%)
		CYCc	224..429	CDD:214485	91/216 (42%)
		Guanylate_cyc	270..432	CDD:278633	76/172 (44%)
		DUF1053	485..592	CDD:283888	20/126 (16%)
		CYCc	848..1052	CDD:214485	85/237 (36%)
		Guanylate_cyc	871..1073	CDD:278633	89/235 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020