DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXA and ADCY6

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_001377760.1 Gene:ADCY6 / 112 HGNCID:237 Length:1168 Species:Homo sapiens


Alignment Length:1164 Identity:300/1164 - (25%)
Similarity:525/1164 - (45%) Gaps:238/1164 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSF-----TEYTKYIYIN 89
            |.:...:.:...||..|.:|..::..||||:.:.:|:|    |..::.:|     .....|:.:.
Human   124 QVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVL----LTAVLLAFHAAPARPQPAYVALL 184

  Fly    90 AIFDLGSLILVTGLLSI----NFFEDFVIRHRWVMTFTST-LSAYVVVLGDIAFNTYYYYKSNWP 149
            |.    :..|..||:.:    :|.:|.:    ||:::... :.|.|.|.|.:|.:........| 
Human   185 AC----AAALFVGLMVVCNRHSFRQDSM----WVVSYVVLGILAAVQVGGALAADPRSPSAGLW- 240

  Fly   150 LNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVH---GLDIVS 211
                ..||.:.:.|..||| ..:||.|..:.:|..::|     :|:..:....::.   |.:::.
Human   241 ----CPVFFVYIAYTLLPI-RMRAAVLSGLGLSTLHLI-----LAWQLNRGDAFLWKQLGANVLL 295

  Fly   212 IDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQ 276
                 :|..|::||......:...|.:|.:...:|...:.|:...||:..||.|:||..:|..::
Human   296 -----FLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMK 355

  Fly   277 KSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLY 341
            :.|..|  :.|..|:.:          .||.|::||||:||:..:|.|.:..|.::||..|::|:
Human   356 EDINTK--KEDMMFHKI----------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELF 408

  Fly   342 ARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRI 406
            ||||..|......|||.||||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:
Human   409 ARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRV 473

  Fly   407 GVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESA 471
            |:|||.:..||:|..|.|:|:|..||.:|:.:||.|..|.:|::..||..||. :|.:.|| ...
Human   474 GIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNG-DYEVEPG-RGG 536

  Fly   472 QKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILK---PNLLSHEMRE 533
            :::..|::..:.|:|:........::...:.:      ||...:|....::.   |:......::
Human   537 ERNAYLKEQHIETFLILGASQKRKEEKAMLAK------LQRTRANSMEGLMPRWVPDRAFSRTKD 595

  Fly   534 E--FRKM--------------------PVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKS 576
            .  ||:|                    .|..|..:...:|....|:.:.|.|    |.:.|:.:.
Human   596 SKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRR----FLLTFQRED 656

  Fly   577 VEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF-YTGVVINIIAFFVLTFLLFICWYKK 640
            :|..|..:.|..|...||....:.|.:.:||.:    || ::.:::.|.|...|..|:.:     
Human   657 LEKKYSRKVDPRFGAYVACALLVFCFICFIQLL----IFPHSTLMLGIYASIFLLLLITV----- 712

  Fly   641 VCWWHSGQNEHRSYGKLSCAIF---HLF----EKIQHSFV------LRLTVYMMIILCYYMVISL 692
                            |.||::   .||    :::..|.|      ..:.::.::::....:.::
Human   713 ----------------LICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM 761

  Fly   693 I------LMSCEKDQYEL---DIIESKL----YNYDMD-PF------TCFHPWAYTNMMALILGM 737
            .      :.||......|   ||....|    |:..:| |.      ||..|..:...|.|.|..
Human   762 FTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLA 826

  Fly   738 SYTFARIPFALKTFIGCAEAVVFVLVVCFQY-------AFIFE--------HSVTTS--PYLKAE 785
            |..|..|....|.      |::|||.:.:..       |.||:        |.:.:|  .:...:
Human   827 SSVFLHISSIGKL------AMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLD 885

  Fly   786 IAHSCRVCMMLIT----------MYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNN 840
            ...:.||.:..:|          :|...:|.|...::::...|....:::..:........||:|
Human   886 CPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHN 950

  Fly   841 ILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------LRVLNDIITAF 894
            |||..|...:|:...:: ||||::...|:||||.:.||.   ::|.:       ||:||:||..|
Human   951 ILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 1015

  Fly   895 DRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQV-RSRLESSIK 958
            |.::|. :::..:||||.:|.|||||.||:                  :|..:|| ||.:.:   
Human  1016 DEIISE-ERFRQLEKIKTIGSTYMAASGLN------------------ASTYDQVGRSHITA--- 1058

  Fly   959 EKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYD 1023
                      :|.:|:.||..:...|        :.:.:..:::||::.|.::|||:||.:|.||
Human  1059 ----------LADYAMRLMEQMKHIN--------EHSFNNFQMKIGLNMGPVVAGVIGARKPQYD 1105

  Fly  1024 IWGNPVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            ||||.||::|||:|||:...||||.:..|.|  :.:.:.|  ||:..|||:||:.|||:
Human  1106 IWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 59/261 (23%)
CYCc 262..464 CDD:214485 81/201 (40%)
Nucleotidyl_cyc_III 306..489 CDD:299850 75/182 (41%)
CYCc 831..1055 CDD:214485 80/237 (34%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 81/233 (35%)
ADCY6NP_001377760.1 AC_N <16..368 CDD:318454 60/273 (22%)
Guanylate_cyc 370..554 CDD:306677 76/195 (39%)
DUF1053 582..668 CDD:399378 15/89 (17%)
Guanylate_cyc 970..1164 CDD:306677 82/235 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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