DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and ADCY3

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	1217	Identity:	316/1217 - (25%)
Similarity:	528/1217 - (43%)	Gaps:	256/1217 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 HLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIY--INAIFDLGSLILV-TG 102
            :|.:.|.|.:....:..|.||..:....:|.:..:::|..:......  |..:.|:...:|. .|
Human    64 NLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKG 128

  Fly   103 LLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTL-YDVFVLCMIYMFL 166
            ||     .|.|.|.  |:.:...|.....:...:..|   :.:::...:|: :.||.:...::.|
Human   129 LL-----PDRVTRR--VLPYVLWLLITAQIFSYLGLN---FARAHAASDTVGWQVFFVFSFFITL 183

  Fly   167 PIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMN 231
            |:..|....:..:|..:..::..: .:|..:....|.:..|..:..:.|.||....:||....|.
Human   184 PLSLSPIVIISVVSCVVHTLVLGV-TVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMA 247

  Fly   232 DTMVRSSFLDRYQFITEEIWL-RQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGT 295
            |...|.:||:..|.:..::.| .|:::||:|:| ||||..:|..:.|.:|:...|.|...:
Human   248 DRKHRKAFLEARQSLEVKMNLEEQSQQQENLML-SILPKHVADEMLKDMKKDESQKDQQQF---- 307

  Fly   296 SRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLG 360
                 |.|.:..|.:||||:||:|.:|||::..:.::|||:|::|:||||..|..:...|||.||
Human   308 -----NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILG 367

  Fly   361 DCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQY 425
            |||||:.||.:...|||..::.:|::|:..|..|.......:.||:|||:||:..||:|:.:.||
Human   368 DCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQY 432

  Fly   426 DIWGADVNIASRLEATGSPG----------------------YVHVSGRTLSSLNAEEYNIYPGT 468
            |:|..||.:|:::||.|.||                      .||:|..|:..|.. |:::.||.
Human   433 DVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLKG-EFDVEPGD 496

  Fly   469 ESAQKDPVLQKHPMSTYLLTA----------------------IPSLDSDKTISIVE-GVPNLDL 510
            ..::.| .|::..:.|||:.|                      .|:.....:.:::| ..||...
Human   497 GGSRCD-YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSA 560

  Fly   511 QTVGS-----NRKSQILKPNLLSHEMREEFRKMPVGGFKF---QFPWSRRERNLK---------- 557
            .:.||     ..:...|.|..|||  ....|.:|  |.:.   .||..||...|:
Human   561 HSSGSTSEKPEEQDAQLFPTTLSH--LPHSRCLP--GSQADNPSFPNPRRRLRLQDLADRVVDAS 621

  Fly   558 ----------NEKV----------ERDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGC- 601
                      ||.:          :|:..:..:.|.|..:|..|..:.:   |.|   |....|
Human   622 EDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKE---KQS---GAAFSCS 680

  Fly   602 CLIYIQSVNNSDIFYTGVVINIIAFFV---LTFLLFIC-------------------WYKKVCWW 644
            |::.:.:.....:....::.|.:.|.|   |..:|.||                   |..:..|
Human   681 CVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRW- 744

  Fly   645 HSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIES 709
                 ...::..|  |||.|        |:...|.|:..|.||...|......|.:...|:  ..
Human   745 -----ARNTWAML--AIFIL--------VMANVVDMLSCLQYYTGPSNATAGMETEGSCLE--NP 792

  Fly   710 KLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAF--IF 772
            |.|||          .|..:::|.|:.:..:. .:...|...:..|.|.:.:      ||:  :|
Human   793 KYYNY----------VAVLSLIATIMLVQVSH-MVKLTLMLLVAGAVATINL------YAWRPVF 840

  Fly   773 ---------EHSV-----------------TTS--PYLKAEIAHSCRVCMMLITMYAKERQSEFN 809
                     ||.:                 |.|  |.:.::.:.:..|.:|:::.|...|..|..
Human   841 DEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKL 905

  Fly   810 TKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAK-HELYYENYRMVSVMFAM 873
            .:..:...:::.::::......:....|:.|:||.||...:|.|..: .|||.:.|..:.||||.
Human   906 ARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFAS 970

  Fly   874 LTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLI 928
            |.||          ...:..||.||:||:.||.||...| :.|:.|||.:|.|||||.|:
Human   971 LPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPK-FRVITKIKTIGSTYMAASGV----- 1029

  Fly   929 ENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFD 993
             ..|.|:| |..|.:.|.:..|.|.:....          :|.|||.:...|:..|        :
Human  1030 -TPDVNTN-GFASSNKEDKSERERWQHLAD----------LADFALAMKDTLTNIN--------N 1074

  Fly   994 RALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFD 1058
            ::.:...:|||::.|.::|||:||.:||||||||.||:||||||||:.|:|||.:||...|.|:.
Human  1075 QSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYG 1139

  Fly  1059 VMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKIDRLSENPSNPDL 1105
            .....||..||||:||:.|:|:          |..|:|:..|:.|.:
Human  1140 FRFVRRGPIFVKGKGELLTFFL----------KGRDKLATFPNGPSV 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	56/253 (22%)
		CYCc	262..464	CDD:214485	80/223 (36%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	75/204 (37%)
		CYCc	831..1055	CDD:214485	88/234 (38%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	90/230 (39%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	55/250 (22%)
		CYCc	273..490	CDD:214485	82/227 (36%)
		Guanylate_cyc	310..516	CDD:278633	76/207 (37%)
		CYCc	925..1143	CDD:214485	90/243 (37%)
		Guanylate_cyc	956..1163	CDD:278633	91/242 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810