DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXA and ADCY2

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1213 Identity:319/1213 - (26%)
Similarity:521/1213 - (42%) Gaps:271/1213 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LWEQS-----YLKARCKE-------LHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSF 79
            :|:::     ||:.|.:|       |....::: |:....:|.....:..|:|:::...:.:   
Human     1 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWL-YESYYCMSQQHPLIVFLLLIVMGSCLAL--- 61

  Fly    80 TEYTKYIYINAIFDLG--------SLILVTGLLSINFFEDFV------IRHRWVMTFTSTLSAYV 130
                    :...|.||        .||.|...|:| ||..|:      :..:.:..|:..:...:
Human    62 --------LAVFFALGLEVEDHVAFLITVPTALAI-FFAIFILVCIESVFKKLLRLFSLVIWICL 117

  Fly   131 VVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLP-----------IPSSKAAALLAISVSLT 184
            |.:|.: |..:....|.|...:.: :|::.::|..||           :.||....:|::.:|.|
Human   118 VAMGYL-FMCFGGTVSPWDQVSFF-LFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT 180

  Fly   185 YVIYFIHFMAFNEH-------NVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDR 242
                    ....||       ||..::.|              |:.|.:.:.:.:..::.::.|.
Human   181 --------PGGKEHLVWQILANVIIFICG--------------NLAGAYHKHLMELALQQTYQDT 223

  Fly   243 YQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQI 307
            ...|...|.|...:||:..||.|:||..||..::..|.:::..|     ..|......||.::.:
Human   224 CNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGP-----KAGQMENTNNFHNLYV 283

  Fly   308 --HNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLG 370
              |.:|||||||:|.:|:|.:..:..:||.:|::|:.:||..|...:..|||.||||||||:||.
Human   284 KRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP 348

  Fly   371 ESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIA 435
            .|.|:||...|.:|:.|...||:|.....::|.||:|||||.:..||||..|.|||:|..||.:|
Human   349 ISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLA 413

  Fly   436 SRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTY--------------L 486
            :.:||.|.||.||:|..||..||. .|.:..| :...:||.|::|.:.||              |
Human   414 NHMEAGGVPGRVHISSVTLEHLNG-AYKVEEG-DGDIRDPYLKQHLVKTYFVINPKGERRSPQHL 476

  Fly   487 LTAIPSLDSDKTISIVE----------------------------GVPNLDLQTVGSNRKSQILK 523
            .....:||..|..:.|.                            .:...|:.....|.:::.|:
Human   477 FRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLR 541

  Fly   524 PNLLSHEMREEFRK---MPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQP 585
            .........||..:   ..:.|...|..|      ||:|.::|    ..:.|.:|.:|..|....
Human   542 TKSQKKRFEEELNERMIQAIDGINAQKQW------LKSEDIQR----ISLLFYNKVLEKEYRATA 596

  Fly   586 DYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICW-------YKK--- 640
            ...|||.|.....|..|:..:|.:........|:... .||.:|.|:||:|:       .||   
Human   597 LPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFG-AAFLLLAFILFVCFAGQLLQCSKKASP 660

  Fly   641 VCWW---HSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQY 702
            :..|   .||...:|.:.::|..|      |..:.:|.:.|:.|..|              .|..
Human   661 LLMWLLKSSGIIANRPWPRISLTI------ITTAIILMMAVFNMFFL--------------SDSE 705

  Fly   703 ELDIIESKLYNYDMDPFTCFHPWAYTNMMAL----------------ILGM--SYTFARIPFALK 749
            |.....:...|      |.|.  |..|.:|:                |||:  ...|.|:.:.||
Human   706 ETIPPTANTTN------TSFS--ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELK 762

  Fly   750 TFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKA-----------EIAHSCRVCMMLITMYAKE 803
            ..|      :.|.:|.:....:..|:.....|.:.           :...|..:.:..||:....
Human   763 MLI------MMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLG 821

  Fly   804 RQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLS-SIAKHELYYENYRMV 867
            ||:|:..::::......:.:::..:.......:||.|:||:||.|.:|: |:...|||:::|..|
Human   822 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCV 886

  Fly   868 SVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACG 922
            .||||.:.:|          :..|..||:||:||..||.|||..| :..|||||.:|.|||||.|
Human   887 CVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATG 950

  Fly   923 LDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAY 987
                                   |..|.|:..|...|:.:..:. .|..||..|:..|...||  
Human   951 -----------------------LSAVPSQEHSQEPERQYMHIG-TMVEFAFALVGKLDAINK-- 989

  Fly   988 AGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQ 1052
                  .:.:..::|:||:.|.::|||:||.:|.||||||.||:||||:|||:...||||:||:.
Human   990 ------HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSL 1048

  Fly  1053 TLEEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKIDR 1095
            .|:.....|..||:..|||:|::.||||..:     ||:.:.:
Human  1049 VLQTLGYTCTCRGIINVKGKGDLKTYFVNTE-----MSRSLSQ 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 52/280 (19%)
CYCc 262..464 CDD:214485 86/203 (42%)
Nucleotidyl_cyc_III 306..489 CDD:299850 82/198 (41%)
CYCc 831..1055 CDD:214485 88/234 (38%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 87/230 (38%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 50/263 (19%)
CYCc 236..439 CDD:214485 87/208 (42%)
Guanylate_cyc 281..465 CDD:278633 81/185 (44%)
DUF1053 495..599 CDD:283888 16/113 (14%)
CYCc 848..1056 CDD:214485 89/240 (37%)
Guanylate_cyc 878..1077 CDD:278633 88/231 (38%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 7/16 (44%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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