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Protein Alignment ACXA and ADCY1

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1219	Identity:	315/1219 - (25%)
Similarity:	516/1219 - (42%)	Gaps:	312/1219 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TPYRERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRL----MISSLTVFV------- 62
            |..|...|.|:.|:.             |.|  ||..:..|.:||    .:.:|.|..
Human    27 TSRRRGLRACDEEFA-------------CPE--LEALFRGYTLRLEQAATLKALAVLSLLAGALA 76

  Fly    63 -------------------PMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINF 108
                               |:..:|.:||.|:     ...:.:.:..:..:|.|.|   |.|:.|
Human    77 LAELLGAPGPAPGLAKGSHPVHCVLFLALLVV-----TNVRSLQVPQLQQVGQLAL---LFSLTF 133

  Fly   109 FEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMI----YMFLPIP 169
                            .|......||..|..:  ...:..|......|:.|.::    |..||:.
Human   134 ----------------ALLCCPFALGGPARGS--AGAAGGPATAEQGVWQLLLVTFVSYALLPVR 180

  Fly   170 SSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTM 234
            |     ||||...|  |:...|.:.......||.......:..:...::|.||.|:|.||:.:..
Human   181 S-----LLAIGFGL--VVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERS 238

  Fly   235 VRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTA 299
            .|.:||.....|.:.:.|.....::..||.|:||..:|    ..:||..::|....:|.
Human   239 QRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVA----MEMKEDFLKPPERIFHK------ 293

  Fly   300 ENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYY 364
               :.||.|::||||:||:|.:|.|.:..|.::|||:|::|:.:||..|.....:|||.||||||
Human   294 ---IYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYY 355

  Fly   365 CVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWG 429
            ||:||.:...|||...|.:|:.||..|..|:....:::.||:|:|:|.:..||:|..|.|||:|.
Human   356 CVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 420

  Fly   430 ADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPS-- 492
            .||.:|:.:||.|.||.||::..||:.||. :|.:.|| ...:::..|:.|.:.|:.:  :||
Human   421 NDVTLANVMEAAGLPGKVHITKTTLACLNG-DYEVEPG-YGHERNSFLKTHNIETFFI--VPSHR 481

  Fly   493 --LDSDKTISIVEGVPNLDLQTV----------GSNRKSQILKPNLLSHEMREEFRKMPVGGFK- 544
              :.....:|.::....:..:||          ....|::|...|:::.|..::.|.:.....|
Human   482 RKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKL 546

  Fly   545 -----------FQFPWSRRERNL-------KNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFKY 591
                       :..|.:|..|.:       :.|....||..|.:.:|....|..|....|..|..
Human   547 RNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTS 611

  Fly   592 SVALG------WGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNE 650
            :|.|.      :|:...||:.||          ||:.::..|.:.||
Human   612 AVVLTLILAALFGLVYLLIFPQS----------VVVLLLLVFCICFL------------------ 648

  Fly   651 HRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISL--ILMSCEKDQYELDIIESKLYN 713
                  ::|.::....::| .|...||:.:..:||.::|:.:  :...|
Human   649 ------VACVLYLHITRVQ-CFPGCLTIQIRTVLCIFIVVLIYSVAQGC---------------- 690

  Fly   714 YDMDPFTCFHPWAY-----TNMMALILGMSYTFARIPFALKTFIGCA---EAVVFVLVVCFQYAF 770
                ...|. |||:     ::::.|..|...|      ||.| :.|.   .|::..||.....|.
Human   691 ----VVGCL-PWAWSSKPNSSLVVLSSGGQRT------ALPT-LPCESTHHALLCCLVGTLPLAI 743

  Fly   771 IFEHS----------VTTSPYLKAEIAHSCR--------------VCMML----ITMYAKERQSE 807
            .|..|          :|||..|..|::...|              |.::|    :.::|  ||.:
Human   744 FFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHA--RQVD 806

  Fly   808 FNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMF 871
            ...:::|......:.:::..:........:|.|:||:||.:.:|.|..:: :|||::|..|.|||
Human   807 IRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMF 871

  Fly   872 AMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYV-VEKIKVVGCTYMAACGLDF 925
            |.:.||          .|.:..||:||:||..||.|:.  |.:|. :||||.:|.|||||.||
Human   872 ASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELME--KDFYKDIEKIKTIGSTYMAAVGL-- 932

  Fly   926 SLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGE 990
                        ..||.:...:.:.|.|.:             :|.||:::..||...|.
Human   933 ------------APTSGTKAKKSISSHLST-------------LADFAIEMFDVLDEINY----- 967

  Fly   991 PFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLE 1055
               ::.:...:|:||:.|.::|||:||.:|.||||||.||:||||:|||:.|.||||:|..:.|.
Human   968 ---QSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLR 1029

  Fly  1056 EFDVMCYY----RGLTFVKGRGEIPTYF--------------VGIDKDL 1086
            .    |.|    ||...|||:||:.|||              :|:|:.:
Human  1030 R----CPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKM 1074

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.