DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Adcy3

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1176	Identity:	318/1176 - (27%)
Similarity:	516/1176 - (43%)	Gaps:	271/1176 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NFFEDFVIRHRW-----VMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPL-----NTLYDV--FVL 159
            |.::.:..|.|.     ::.|.:....||||:..:.|::    ....||     ..:.|:  |||
Mouse    64 NLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS----DKLAPLMVAGFGLVLDIILFVL 124

  Fly   160 C------------------------MIYMFLPIPSSKAAA---------------LLAISVSLTY 185
            |                        .|:.:|.:..|:|.|               .:.:.:||:.
Mouse   125 CKKGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSP 189

  Fly   186 VIYF------IHFMAFNEHNVAKY----VHGLDI---VSIDFFHYLGFNMMGIFFRIMNDTMVRS 237
            ::..      :|.:.... .||:.    :.|:.:   :..:.|.||...::||....|.|...|.
Mouse   190 IVIISVVSCVVHTLVLGV-TVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRK 253

  Fly   238 SFLDRYQFITEEIWL-RQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAEN 301
            :||:..|.:..::.| .|:::||:|:| ||||..:|..:.|.:|:...|.|...:         |
Mouse   254 AFLEARQSLEVKMNLEEQSQQQENLML-SILPKHVADEMLKDMKKDESQKDQQQF---------N 308

  Fly   302 FMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCV 366
            .|.:..|.:||||:||:|.:|||::..:.::|||:|::|:||||..|..:...|||.|||||||:
Mouse   309 TMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCI 373

  Fly   367 AGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGAD 431
            .||.:...|||..::.:|::|:..|..|.......:.||:|||:||:..||:|:.:.|||:|..|
Mouse   374 CGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTD 438

  Fly   432 VNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLL--------- 487
            |.:|:::||.|.||.||:|..|:..|.. |:::.||...::.| .|.:..:.|||:
Mouse   439 VTVANKMEAGGIPGRVHISQSTMDCLKG-EFDVEPGDGGSRCD-YLDEKGIETYLIIASKPEVKK 501

  Fly   488 TAIPSLDSDKTISIVEGVPNLDLQTVGSNRKS-----QILKPNLLSH---EMREEFRKMPVGGFK 544
            ||...|:..   ::..|.|       .|::.|     :..:||..:|   ...||..:.......
Mouse   502 TAQNGLNGS---AVPNGAP-------ASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADN 556

  Fly   545 FQFPWSRRERNLK--------------------NEKV----------ERDLGIFCVAFKDKSVEW 579
            ..||..||...|:                    ||.:          :|:..:..:.|.|..:|.
Mouse   557 PSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMET 621

  Fly   580 NYLHQPDYIFKYSVALGWGIGCCLIYIQS----------VNNSDIFYTGVVINII-------AFF 627
            .|..:.:   |.|.| .:...|.:::..:          :.|...|..|.|:.:|       |.|
Mouse   622 RYSVEKE---KQSGA-AFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIF 682

  Fly   628 VLTF----LLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYM 688
            ..:|    :.|..|..:..|      ...::..|  |||.|        |:...|.|:..|.|||
Mouse   683 PRSFPKKLVAFSSWIDRTRW------ARNTWAML--AIFIL--------VMANVVDMLSCLQYYM 731

  Fly   689 VISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIG 753
            ....:....|.|...::  ..|.|||          .|..:::|.|:.:..:. .:...|...:.
Mouse   732 GPYNMTAGMELDGGCME--NPKYYNY----------VAVLSLIATIMLVQVSH-MVKLTLMLLVT 783

  Fly   754 CAEAVVFVLVVC----------FQ-----YAFIFEHSVTTSPYLKAEIA--------HSCRVCM- 794
            .|...:.:...|          ||     ...:.:..|..:|.|....:        :|..|.|
Mouse   784 GAVTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMF 848

  Fly   795 -MLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAK-H 857
             |:::.|...|..|...:..:...:::.::::......:....|:.|:||.||...:|.|..: .
Mouse   849 VMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDE 913

  Fly   858 ELYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKV 912
            |||.::|..:.||||.|.||          ...:..||.||:||:.||.||...| :.|:.|||.
Mouse   914 ELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPK-FRVITKIKT 977

  Fly   913 VGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEK-NH--DEVAFIMATFAL 974
            :|.|||||.|:      ..|.|:| |.||.|.|        |.|.||: .|  |     :|.|||
Mouse   978 IGSTYMAASGV------TPDVNTN-GFTSSSKE--------EKSDKERWQHLAD-----LADFAL 1022

  Fly   975 DLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTG 1039
            .:...|:..|        :::.:...:|||::.|.::|||:||.:||||||||.||:||||||||
Mouse  1023 AMKDTLTNIN--------NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTG 1079

  Fly  1040 LSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV-GIDKDLKFMSKKIDRLSENPSNP 1103
            :.|:|||.:||...|.|:......||..||||:||:.|:|: |.|:...|         .|.|:.
Mouse  1080 VMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAF---------PNGSSV 1135

  Fly  1104 DLNHDL 1109
            .|.|.:
Mouse  1136 TLPHQV 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	53/248 (21%)
		CYCc	262..464	CDD:214485	80/201 (40%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	75/191 (39%)
		CYCc	831..1055	CDD:214485	94/237 (40%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	96/233 (41%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	52/244 (21%)
		Guanylate_cyc	310..494	CDD:306677	76/185 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		12/69 (17%)
		Guanylate_cyc	915..1122	CDD:306677	97/235 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810