Protein Alignment ACXA and Adcy4

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_001348533.1
• Gene: Adcy4 / 104110
• MGIID: 99674
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1157
• Identity: 310/1157 - (26%)
• Similarity: 515/1157 - (44%)
• Gaps: 241/1157 - (20%)

  Fly    57 SLTVFVPMLILL-------IVALQVIIW-SFTEYTK--YIYINAIFDLGSLILVTGLLSINFFED 111
            ||:...|:||||       :|||..:.| |..|.|.  ......:..||...|:.||.|
Mouse    22 SLSQQYPLLILLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLAS------ 80

  Fly   112 FVIRHRWVMTFTSTLSAYV-VVLGDIAFNTYYY--YKSNWPLNTLYDVFVLCMIYMFLPIPSSKA 173
               |.:.:..:|..||..: |.|..:.:...:.  ..|.|...:.: :|::..:|..||:....|
Mouse    81 ---REQQLQRWTRPLSGLIWVALLALGYGFLFTGGVVSAWDQVSFF-LFIIFTVYAMLPLGMRDA 141

  Fly   174 AALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSS 238
            ||...|| ||::::....::.:...:....:..|...::.|   |..|::|.:.:.:.:..:|::
Mouse   142 AAAGVIS-SLSHLLVLGLYLGWQPESQRALLPQLAANAVLF---LCGNVVGAYHKALMERALRAT 202

  Fly   239 FLD-------RYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKI-----IQPDNDFY 291
            |.:       |.:..||:      :.||.||| ||||..:|:.::..|..::     .:|:|
Mouse   203 FREALSSLHSRRRLDTEK------KHQEHLLL-SILPAYLAREMKAEIMARLQAGQRSRPEN--- 257

  Fly   292 HLGTSRTAENFMSIQI--HNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQ 354
                   ..||.|:.:  |..||:||||:|.:|:|.:..:.::||.:|::|:.:||..|...:..
Mouse   258 -------TNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECM 315

  Fly   355 RIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIG 419
            |||.||||||||:||..|.||||...|.:|:.|...|:::.|...::|.||:|||||::..||||
Mouse   316 RIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIG 380

  Fly   420 KAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMST 484
            ..|.|||:|..||.:|:.:||.|.||.||::|.||:.| |..|.: ...::..:||.|::....|
Mouse   381 LQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL-AGAYAV-ERADTEHRDPYLRELGEPT 443

  Fly   485 YLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNL-----------------LSHEMR 532
            ||:.. |..:.:......:|:.        |:.:...::|:|                 |||...
Mouse   444 YLVID-PRAEEEDEKGTAKGLL--------SSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHLDS 499

  Fly   533 EEFRKMPVGGFKFQFPW----SRRERNLKNE---------------------KVERDLGIFCVAF 572
            ......|:....|...|    ||..|.|.:|                     |..:|..:..:.|
Mouse   500 PVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYF 564

  Fly   573 KDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTG----VVINIIAFFVLTFLL 633
            ::|.:|..|.......|||..|..:     |:::.:.....:..|.    ::...|.|.:...||
Mouse   565 REKEMEKQYRLSALPAFKYYAACTF-----LVFLSNFTIQMLVTTRPPALIITYSITFLLFFLLL 624

  Fly   634 FICWYKKVCWWHSGQNEHRSYGKLSCA-----IFHLFEKI------QHSFVLRLTVYMMIILCYY 687
            |:|:           :||.:    .|.     :.|....:      :..|.:.|....::::...
Mouse   625 FVCF-----------SEHLT----KCVQKGPKMLHWLPALSVLVATRPGFRVALGTATILLVFTM 674

  Fly   688 MVISLILMSCEKD-QYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKT- 750
            .:.||:.:....| .:....:.|..:|..         |.....:.||   |.....||:::..
Mouse   675 AIASLLFLPVSSDCLFLASNVSSVTFNAS---------WEMPGSLPLI---SIPLISIPYSMHCC 727

  Fly   751 ---FIGCA-------EAVVFVL---VVCFQYAFIFEHS--------------------VTTSPYL 782
               |:.|:       |..:.:|   :|.....|:..|:                    |...|.|
Mouse   728 VLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQSPSDSRPGVLKEPKL 792

  Fly   783 KAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVV 847
            ...|    ...:...|:....||:|:..::::.....|:.:::..:.......:||.|:||:||.
Mouse   793 MGAI----YFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVA 853

  Fly   848 EVYLSSIAKHE-LYYENYRMVSVMFAMLTNFQ----------MDLPSLRVLNDIITAFDRLLSAY 901
            ..::....::| ||:::|..|.|:||.:.:|:          ..|..||:||:||..||.|||..
Mouse   854 PQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKP 918

  Fly   902 KQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVA 966
            | :..|||||.:|.|||||.||:.:..::...:|....:.|.:
Mouse   919 K-FSGVEKIKTIGSTYMAATGLNATSGQDTQQDSERSCSHLGT---------------------- 960

  Fly   967 FIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNM 1031
              |..||:.|...|.|.||        .:.:...:|:|::.|.::|||:||.:|.||||||.||:
Mouse   961 --MVEFAVALGSKLGVINK--------HSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNV 1015

  Fly  1032 ASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFVGID 1083
            ||||||||:.|.||||:|||:.|:.....||.||...|||:||:.|||:..|
Mouse  1016 ASRMESTGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCTYFLNTD 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	62/258 (24%)
		CYCc	262..464	CDD:214485	86/208 (41%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	79/184 (43%)
		CYCc	831..1055	CDD:214485	85/234 (36%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	89/230 (39%)
Adcy4	NP_001348533.1	AC_N	<115..246	CDD:318454	34/142 (24%)
		Guanylate_cyc	264..418	CDD:306677	70/153 (46%)
		DUF1053	479..580	CDD:368844	17/100 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..524		5/21 (24%)
		Guanylate_cyc	866..1065	CDD:306677	90/231 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880