Protein Alignment ACXA and adcy6

DIOPT Version :10

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_002935166.2
• Gene: adcy6 / 100493933
• XenbaseID: XB-GENE-1011902
• Length: 1239
• Species: Xenopus tropicalis
• Alignment Length: 1168
• Identity: 297/1168 - (25%)
• Similarity: 516/1168 - (44%)
• Gaps: 248/1168 - (21%)

  Fly    30 QSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTE---YTKYIYINAI 91
            |.:...:.:...||..|.:|..::..||||:.:..|:|  |.|.::|:..|.   ...|:.:.|:
 Frog   196 QVFQSKKFQSAKLERLYQRYFFQMNQSSLTMLMGALVL--VCLVMLIFHCTHGEPQVVYVSVLAV 258

  Fly    92 FDLGSLILVTGLLSI----NFFEDFVIRHRWVMTFTSTLSAYVV-VLGDIAFNTYYYYKSNWPLN 151
                ::.|...|:.:    .|.:|::    |::::......:.| |||.:........:..|
 Frog   259 ----AMALFLSLMVVCNRNGFHQDYM----WIVSYLVIAVLFAVQVLGVLMVTPRSASEGIW--- 312

  Fly   152 TLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDI-----VS 211
              :.||.:.:||..||: ..:||.|..:.:|..::|            ::..::..||     :|
 Frog   313 --WSVFFIYIIYTLLPV-RMRAAVLSGLILSSLHLI------------ISWRLNLTDIFLWKQLS 362

  Fly   212 IDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQ 276
            .:...:|..|::||......:...|.:|.:...:|...:.|::..:|:..||.|:||..:|..::
 Frog   363 ANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMK 427

  Fly   277 KSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLY 341
            :.|..|  :.|..|:.:          .||.|::||||:||:..:|.|.:..|.::||..|::|:
 Frog   428 EDINTK--KEDMMFHKI----------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELF 480

  Fly   342 ARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRI 406
            ||||..|......|||.||||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:
 Frog   481 ARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRV 545

  Fly   407 GVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESA 471
            |:|||.:..||:|..|.|:|:|..||.:|:.:||.|..|.:|::..||..||. :|.:.|| ...
 Frog   546 GIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITSATLKYLNG-DYEVEPG-NGG 608

  Fly   472 QKDPVLQKHPMSTYLLTAIPSLDSDKTISIV----------EG-----VP--------------- 506
            :::..|::|.:.|:|:|.......::...:.          ||     ||
 Frog   609 ERNAYLKEHDIKTFLVTGCSQKRKEEKAMMARLQRARANSNEGLTRVWVPERSFPRNKGSKAFRQ 673

  Fly   507 -NLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCV 570
             .:|..:..:....:.|.|    .:..:||....:.        :|....|:.:.|::    |.:
 Frog   674 MGIDESSKDNRNTQEALNP----EDEVDEFLARAID--------ARSIDQLRKDHVKK----FLL 722

  Fly   571 AFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF---------YTGVVINIIAF 626
            .|:...:|..|..:.|..|...|.....:.|.:.:||.|    ||         ||.|      |
 Frog   723 TFQTPDLEKKYSKKVDDRFGGYVTCTLLVFCFICFIQIV----IFPHSFLMLGVYTSV------F 777

  Fly   627 FVLTFLLFICWYKKVCWWHSGQNEHRSYGKLSC------AIFHLFEKIQHSFVLRLTVYMMIILC 685
            .:|..:||:|                  ...||      |:..:..||..|......:.::.||.
 Frog   778 IILASILFVC------------------AIYSCIKLFPAALQGVSRKIVQSRTNSTLIGILTILL 824

  Fly   686 YYMVISLILMSCE------------KDQYE-LDIIESKLYNY---------DMDPFTCFHPWAYT 728
            .:....:.:.:|.            ...|: :::...::.||         |.|...|..|..:.
 Frog   825 VFTSAFVNMFACNHRSLTDCAGQELNISYKFVNVCHLRMLNYSLSMDSPPCDSDKPLCNFPEYFN 889

  Fly   729 NMMALILGMSYTFARI----PFALKTFIGCAEAVVFVLVVCFQYAFIFEH-----SVTTSPYLKA 784
            ..:.|.|.....|.:|    ..||..||    .::::::|......:|::     :|...|....
 Frog   890 YSILLSLLACSVFLQISSIGKLALMLFI----QILYIVIVEGPEVVLFDNYDLLVTVNALPINGT 950

  Fly   785 ----EIAHSCRVCMMLIT----------MYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSII 835
                |...|.::.:..:|          :|...:|.|...::::...|....:::..:.......
 Frog   951 GDIEECLPSSKIALKFVTPVILTVFVLALYLHAQQVESTARLDFLWKLQATGEKEEMEQLQAYNR 1015

  Fly   836 ILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------LRVLND 889
            .||:||||..|...:|:...:: ||||::...|:||||.:.||.   ::|.:       ||:||:
 Frog  1016 RLLHNILPKDVAAHFLAREHRNDELYYQSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNE 1080

  Fly   890 IITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLE 954
            ||..||.::|..| :..:||||.:|.|||||.||      |..:....|.|.:::
 Frog  1081 IIADFDEIISEEK-FKQLEKIKTIGSTYMAASGL------NDTTYDKEGKTHITA---------- 1128

  Fly   955 SSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQ 1019
                          :|.:|:.|...:...|        :.:.:..:::||::.|.::|||:||.:
 Frog  1129 --------------LADYAMKLREQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARK 1171

  Fly  1020 PHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            |.||||||.||:||||:||||...||||.:..|.|  :.:.:.|  ||:..|||:||:.|||:
 Frog  1172 PQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMEC--RGVIKVKGKGEMTTYFL 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AcyC	88..457	CDD:441717	112/378 (30%)
		Nucleotidyl_cyc_III	306..489	CDD:448371	76/182 (42%)
		Nucleotidyl_cyc_III	859..1080	CDD:448371	81/232 (35%)
adcy6	XP_002935166.2	AC_N	89..440	CDD:318454	59/273 (22%)
		Guanylate_cyc	442..626	CDD:425528	77/195 (39%)
		Adcy_cons_dom	656..741	CDD:461877	15/100 (15%)
		Guanylate_cyc	1040..1233	CDD:425528	82/234 (35%)