Protein Alignment ACXA and gucy2f

DIOPT Version :10

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_002931862.2
• Gene: gucy2f / 100492820
• XenbaseID: XB-GENE-480268
• Length: 1112
• Species: Xenopus tropicalis
• Alignment Length: 1103
• Identity: 220/1103 - (19%)
• Similarity: 369/1103 - (33%)
• Gaps: 397/1103 - (35%)

  Fly    98 ILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMI 162
            :|:.|.......|   :.|...||.    ..||.|..|..:.:..|:|      |.||
 Frog   256 VLIGGQAQQRLLE---VAHDLKMTD----GTYVFVPYDTLYYSLPYHK------TTYD------- 300

  Fly   163 YMFLPIPSSKAA--ALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGI 225
             |....|:..||  ::|.|:|......::..|....|...
 Frog   301 -MLKNSPNLTAAYDSVLTITVESEGKTFYEAFQEAQESGE------------------------- 339

  Fly   226 FFRIMNDTMVRSSFLDRYQFITEEIW-----LRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQ 285
                ||..:..|.....:..|...|:     :..:|||.:.:..|.|... :|.:|
 Frog   340 ----MNANIKPSQVSPLFGTIYNAIYFTAYAMNSSRRQGTWVSGSSLVKH-SKNMQ--------- 390

  Fly   286 PDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALS 350
                ||  |.::..:..||.....|..||.||:              ....||..|      .:.
 Frog   391 ----FY--GFNQWIKTDMSGNGFTDYVILDADM--------------KTNELHRTY------VVD 429

  Fly   351 FKVQRIKFLGD---------------CYY-----CVAGLGESDPDHATMAVSLGISMIANIKEVS 395
            .:...::::|.               |::     |..|:   :|..|.|.....:..|.::..::
 Frog   430 METDMVRYMGRPIHFPNGVSPKTDSYCWFSDGKICTGGI---EPAFALMVFLCIVVAIISLNGLA 491

  Fly   396 --VNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVH--VSGRTLSS 456
              :.|.:|                  |.||   :.|.:..:.:..:.|    :::  :|.:.||:
 Frog   492 YVIRRRIN------------------KIKL---VRGPNKILLTLEDVT----FINPQLSVKKLSN 531

  Fly   457 LNAEEYNIYPGTESAQKDPVL-----QKHPM---STYLLTAIPSLDSDKTISIVEG-------VP 506
                     .|:.::...|||     .|.||   ||..|  ||:...:..::|.||       .|
 Frog   532 ---------DGSRTSDSGPVLTDTRSMKSPMRSGSTQSL--IPATYENSNVAIYEGDWVWMKKFP 585

  Fly   507 NLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIF--C 569
            :.|...         |||.     ..:.|..|               :::::|.|...||.|  |
 Frog   586 SGDFGE---------LKPG-----TSDVFETM---------------KDMRHENVNPFLGFFHDC 621

  Fly   570 VAF-------KDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFF 627
            ..|       ...|:|       |.:....|.|.|                :|.:.:::::|
 Frog   622 GVFAIVTEFCSRGSLE-------DLLRNQDVKLDW----------------MFKSSLLLDLI--- 660

  Fly   628 VLTFLLFICWYKKVCWWHSGQNEHRSY--GKL---SCAIFHLFEKIQHSFVLRLTVYMMIILCYY 687
                       |.:.:.|     ||.:  |:|   :|.       :...|||::|.|     .|.
 Frog   661 -----------KGMKYLH-----HRKFVHGRLKSRNCV-------VDGRFVLKVTDY-----GYN 697

  Fly   688 MVISLILMSCEK-DQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARI------- 744
            .|:....:..|: ..|||.....:|..   ||.:..|        ....|..|:|:.|
 Frog   698 EVLEAQRIPHEEPTAYELLWTAPELLR---DPLSAVH--------GSFSGDVYSFSVIMQEVVVR 751

  Fly   745 --PFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIA---HSCRVCMMLITMYAKE- 803
              ||.  |....||.::              ..|...|.|...:.   |:...|::|:.....|
 Frog   752 GPPFC--TVEDTAEEII--------------QKVKKPPPLCRPMVSPDHAPMECIILMKKCWNEV 800

  Fly   804 --RQSEFN------------TKMN-----------YKLNLD--LQNKQKSADVTNQSIIILLNNI 841
              |:..|:            .|.|           |..||:  ::.:.:..::..|....||..:
 Frog   801 PDRRPSFDEIFDQFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQM 865

  Fly   842 LPSHVVE-------VYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLS 899
            ||..|.|       |......:..||:.:.    |.|..::.....:..:.:|||:.|.||.::.
 Frog   866 LPPSVAEALKMGCTVEPEGFDEVTLYFSDI----VGFTSISAMSEPIEVVDLLNDLYTLFDAVIG 926

  Fly   900 AYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDE 964
            .:..|    |::.:|..||.|.||                                  .::|.:.
 Frog   927 NHDVY----KVETIGDAYMVASGL----------------------------------PKRNGNR 953

  Fly   965 VAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPV 1029
            .|..:|..:||::..:......:..:...|      ||||:.:|..:|||||.:.|.|.::|:.|
 Frog   954 HAAEIANMSLDILSSVGSFKMRHMPDVPVR------IRIGLHSGPAVAGVVGLTMPRYCLFGDTV 1012

  Fly  1030 NMASRMESTGLSGHIQVTKETAQTLEEFD--VMCYYRGLTFVKGRGEIPTYFV----GIDKDL 1086
            |.|||||||||...|.|.:.|.:||...:  .:...||.|.:||:|...|:::    |..|.|
 Frog  1013 NTASRMESTGLPYRIHVNQSTVKTLRSLNEGYLLELRGRTELKGKGIEETFWLVGKEGFTKPL 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AcyC	88..457	CDD:441717	67/389 (17%)
		Nucleotidyl_cyc_III	306..489	CDD:448371	36/214 (17%)
		Nucleotidyl_cyc_III	859..1080	CDD:448371	60/222 (27%)
gucy2f	XP_002931862.2	PBP1_sensory_GC_DEF-like	58..439	CDD:380594	49/268 (18%)
		PK_GC-2D	553..820	CDD:270945	71/378 (19%)
		HNOBA	<829..874	CDD:462234	10/44 (23%)
		CYCc	853..1044	CDD:214485	61/238 (26%)