DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and gucy2g

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_009305067.2	Gene:	gucy2g / 100333350	ZFINID:	ZDB-GENE-130531-70	Length:	1127	Species:	Danio rerio

Alignment Length:	874	Identity:	177/874 - (20%)
Similarity:	324/874 - (37%)	Gaps:	255/874 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 YTQLTTTLTVEKLVKVLHD---LYARFDLAALSFK-----------VQRIKFLGDC-YYCVAGL- 369
            |:.|::...|......|||   |||.....|  ||           ||:::..... :|..:||
Zfish   328 YSNLSSVKEVSSYAAYLHDAVLLYAMGLKEA--FKSGKDIRHGREIVQKLRDRTSIRFYGASGLV 390

  Fly   370 -----GESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTL-FAGVI---GKAKLQY 425
                 ||.:.|::...:....::   |:.|||   |:......:...|| |:.::   ||.....
Zfish   391 HFDEYGERNLDYSVYDLQQTETL---IQFVSV---LDFDSHTKMIKPTLRFSNIVWQNGKPPTDN 449

  Fly   426 DIWGAD----------VNIASRLEATGSPGYVHVSGRTLSSL-------NAEEYNIYPGTESAQK 473
            ...|.|          :::...|.|....|...||..||.:|       ..:|.|.:....|
Zfish   450 PSCGFDNELCEWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKLRLQSRLDESNWWLINYS--- 511

  Fly   474 DPVLQKHPMSTYLLT--AIPS----------LDSDK---------TISIVEGVPNLDLQTVG-SN 516
            |..:.:.|..|.:|:  ..||          |.|:.         |:.:.:|      ..|| ..
Zfish   512 DITILREPKGTQILSVNTTPSKCGSGGSQSMLSSNSCNTREAIYATVGLFQG------NEVGIKY 570

  Fly   517 RKSQIL----KPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGI---------- 567
            .|:||:    ||::::     ||..:               :.:|:|.:.:..|:
Zfish   571 LKNQIIPDIKKPSIIA-----EFNML---------------KEMKHENLVQFFGVCIDPPNVCIV 615

  Fly   568 --FCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVN-------NSDIFYTGVVINI 623
              :|.....|.|..|:....|::||.|.|.....|...|:..|:.       ::.:..:.:.|.:
Zfish   616 MQYCKKGSLKDVLGNHEIDLDWMFKLSFAYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKL 680

  Fly   624 IAFFVLTFLLFICW------------YKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRL 676
            ..|.:..|.   |.            |:::.|         :..:....||:.|...|..
Zfish   681 SGFGLWEFK---CGTKHRLIPLDSPKYEEMYW---------TAPEFLREIFYPFNGTQKG----- 728

  Fly   677 TVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTF 741
            .||...|                      ||...:|:.::.|:...|    .....:|..:....
Zfish   729 DVYSFAI----------------------IIRELIYSTEVGPYHDVH----LEPKEIIKQLRTPM 767

  Fly   742 ARIPF--ALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPY--LKAEIAHSCRVCMMLITMYAK 802
            :..|.  .|...| |.|.::.::..|:.     |:.....|:  ::.::..:|.      ..:|.
Zfish   768 SEEPLRPTLSADI-CDERLIPLIKACWS-----ENPDHRPPFGSIRRQLRDACP------ESHAN 820

  Fly   803 ERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIII--LLNNILPSHVVEVYLSSIAKHELYYENYR 865
            ...:..|....|..:|:...:::::.:|.:....  ||:::||.::.:   ..:|...:...:|.
Zfish   821 ILDNMVNKLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIAD---QLMAGKSVEPRSYE 882

  Fly   866 MVSVMFAMLTNF------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLD 924
            ||::.|:.:..|      ...|..:.:|||:.:.||.::..|..|    |::.:|..||.|.||.
Zfish   883 MVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVY----KVETIGDAYMVASGLP 943

  Fly   925 FSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAG 989
            .|           ..|..:.|:..:.....||||.                 .::..:.|:..|
Zfish   944 IS-----------NGTLHAEEISTMALHFLSSIKR-----------------FKIRHLPNERLA- 979

  Fly   990 EPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQ-- 1052
                       :||||::|.::|||||::.|.|.::|:.||.||||||..|...|.:::.||.
Zfish   980 -----------LRIGINSGPVVAGVVGSTMPRYCLFGDTVNTASRMESNSLPLKIHISQSTADIL 1033

  Fly  1053 -TLEEFDVMCYYRGLTFVKGRGEIPTYFV 1080
             |:..|::  ..||...:||:|...|:::
Zfish  1034 LTIGTFEL--EERGDIEIKGKGTQKTFWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485	41/184 (22%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	47/211 (22%)
		CYCc	831..1055	CDD:214485	60/234 (26%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	62/229 (27%)
gucy2g	XP_009305067.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900