DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and adcy8

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1196	Identity:	315/1196 - (26%)
Similarity:	507/1196 - (42%)	Gaps:	284/1196 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WEQSY-------LKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKY 85
            |..:|       |:...|...||..|.:|.:.....|:.|   |.||.:|            ||.
Zfish   119 WGYTYRGVIFPTLRYAFKSRDLERLYQRYFLGQRRKSVVV---MNILDVV------------TKL 168

  Fly    86 IYINAIFDLGSLIL--VTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKS-- 146
            ..:.....|.|..:  :.|:| :.||....:          .:.|.|||..|.:.:.|..|..
Zfish   169 TLLVLHLTLASTPMDPIKGML-LGFFTGIEV----------VICALVVVRKDTSSHGYLQYSGAV 222

  Fly   147 NWPLNTL-----------------YDVFVLCMIYMFLPIPSSKA--AALL--AISVSLTYVIYFI 190
            .|.....                 |.:|.|...|..||:|.:.|  |.||  |:.::|..::...
Zfish   223 TWVAMATQILATGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAIVAGLLTSALHIALQLLVPPR 287

  Fly   191 HFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLR-Q 254
            ..::.|:            :......:|..|..|:|...::|...|.:||:..:.|...:.|. :
Zfish   288 AQISTNQ------------LLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETE 340

  Fly   255 ARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIH--NDVSILYAD 317
            .:|||.|:| |:||..:           :::..||..::........|..|.||  .:||||:||
Zfish   341 NQRQERLVL-SVLPRFV-----------VLEMINDMTNVEDETLQHQFHRIYIHRYENVSILFAD 393

  Fly   318 LVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVS 382
            :..:|.|:|||:.::||::|::|:||||..|......|||.||||||||:||.|..||||...|.
Zfish   394 VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVE 458

  Fly   383 LGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYV 447
            :|:|||..|:.|......:|.||||:|||::..||:|..|.|:|:|..||:||::||:.|.||.:
Zfish   459 MGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRI 523

  Fly   448 HVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTY--------LLTAIPSLDSDKT------ 498
            |:|...|..||. :|.:..| ....::..|::|.:.|:        |||....:..|.|
Zfish   524 HISKAALDCLNG-DYEVEEG-HGKDRNDFLRRHNIETFLIKQPEESLLTLPEDIMRDSTNQSDHR 586

  Fly   499 ---ISIVEGV--PNLDLQTV--------GSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWS 550
               .|..||.  |.|....:        ...|.|..|.||.|:..:........:.. :.|...:
Zfish   587 TSNTSFTEGTWSPELPFHNIVGKQNTLAALTRHSINLLPNHLAQALHVRAGSQEINA-RMQSTIA 650

  Fly   551 RRERNLKNEKVERD-LGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDI 614
            .|    ..:|:.:: :..|.:.|::..:|..|....|.:||.::.      |..|.:       .
Zfish   651 LR----SGDKLRQEHISPFSLTFREALLEHKYSQMRDEVFKSNLV------CAFIVL-------F 698

  Fly   615 FYTGV---------VINIIAFFVLTFLLFICW--------YK-------KVCWWHSGQNEHRSYG 655
            |.||:         |..:|.|.|| .||..|.        ||       |.|.|
Zfish   699 FITGIQSLLPSARMVTMLIQFSVL-ILLHCCLVVVTTAEDYKCLPLVLRKACCW----------- 751

  Fly   656 KLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMD-PF 719
                        :..::..|..|..:.||..::...:.::.|:.|  :.....::.:|.... |.
Zfish   752 ------------VNETYAARNVVIFLSILINFLAAMINILWCDFD--KSGSFRNQTFNASASIPD 802

  Fly   720 TCFHP--WAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVT----- 777
            .||:|  :.:|.::|::  ....|.|:...||.      |::.:::..  ||.:.|...|
Zfish   803 ICFYPEYFVFTGVLAMV--TCAVFLRLNSVLKL------AILLIMIAI--YAVLTEAFYTPLFIR 857

  Fly   778 --------TSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQ---NKQKSADVTN 831
                    :..:|..:......:.|.|:.::...:|.|:..::::...:..:   |:.:.....|
Zfish   858 YDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHN 922

  Fly   832 QSIIILLNNILPSHVVEVYLSSIA-KHELYYENYRMVSVMFAMLTNF----------QMDLPSLR 885
            ::   :|.|||||||...:|.... ..|||.::|..|.||||.:..|          ...:..||
Zfish   923 EN---MLRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLR 984

  Fly   886 VLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVR 950
            :||:||..||.||.. :::..:||||.:|.||||..||
Zfish   985 LLNEIIADFDELLGE-ERFQDIEKIKTIGSTYMAVSGL--------------------------- 1021

  Fly   951 SRLESSIKEKNHDEVAFI--MATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAG 1013
                |..|::..|:...:  :|.||:.|...:...||        .:.:..::|||::.|.::||
Zfish  1022 ----SPEKQQCEDKWGHLCALADFAIALNESIQEINK--------HSFNNFQLRIGMAHGSVVAG 1074

  Fly  1014 VVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKG----RGE 1074
            |:||.:|.|||||..||:||||:|||:||.||:.:||...|.|......|||..:|||    .|:
Zfish  1075 VIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGISEQEGK 1139

  Fly  1075 IPTYFVGIDKDLKFMSKKIDRLSENP 1100
            |.|:|:            |.|:..||
Zfish  1140 IRTHFM------------IGRVQPNP 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	60/274 (22%)
		CYCc	262..464	CDD:214485	85/203 (42%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	83/192 (43%)
		CYCc	831..1055	CDD:214485	80/236 (34%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	80/236 (34%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	61/288 (21%)
		CYCc	340..538	CDD:214485	88/210 (42%)
		Guanylate_cyc	379..563	CDD:278633	82/185 (44%)
		DUF1053	592..685	CDD:283888	18/97 (19%)
		CYCc	919..1123	CDD:214485	82/246 (33%)
		Guanylate_cyc	948..1147	CDD:278633	81/250 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910