DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and LAF1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_013820.1	Gene:	LAF1 / 855128	SGDID:	S000004708	Length:	834	Species:	Saccharomyces cerevisiae

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	138/384 - (35%)	Gaps:	139/384 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGA---- 101
            |.|.:|.|.:|..:|                 ||:.:.|||.:|:::|:.|.|..|:||..
Yeast   159 GETVTSTSKSSEPTS-----------------KAIWSTKFSRDGKFMATGSKDGKIRIWKVIGSP 206

  Fly   102 ---------------------------------------------YDGKFEKTIS---------- 111
                                                         |:.| ||.::
Yeast   207 VERAELDSSAESNKEARAKSMRIKQQVSSLNNPKEKQFLDSATEKYEEK-EKLLNLYAPVFHPTP 270

  Fly   112 -----GHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNP-QSNL 170
                 .|...:.|:.||.:: .::|.|.|||:|:|......||||.. |.::|.|..|:| ....
Yeast   271 LRLYKEHVQDVLDINWSKNN-FILSASMDKTVKLWHPDRKNSLKTFI-HPDFVTCVEFHPTDDRF 333

  Fly   171 IVSGSFDESVRIWDVRTGK------CLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDT- 227
            .:||..|...|:|.:...:      |       .|.:::|..: .:|...:..:::|...|..|
Yeast   334 FISGCLDHKCRLWSILDDEVSFEYDC-------QDLITSVTLSPEEGKYTIIGTFNGYVHILMTR 391

  Fly   228 -----ASGQCLKTLIDDDNPPV------SFVKFSP--NGKYILAATLDNT-----------LKLW 268
                 :|.........:.|..|      |.::..|  .|.....:.|||:           ::::
Yeast   392 GLTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSNDSRIRIF 456

  Fly   269 DYSKGKCLKTYTG-------HKNEKYCIFANFSVTGGK-WIVSGSEDNMVYIWNLQSKE 319
            |..:.|.|:...|       ||       |..|:..|: .:|:.|:|:.||.|.|:|.:
Yeast   457 DLEQRKLLEVLKGFHSGSSQHK-------AQLSIWHGQPIVVNSSDDHWVYGWRLKSSD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	74/361 (20%)
		WD40 repeat	75..112	CDD:293791	14/100 (14%)
		WD40 repeat	118..154	CDD:293791	14/35 (40%)
		WD40 repeat	159..195	CDD:293791	10/42 (24%)
		WD40 repeat	202..237	CDD:293791	6/41 (15%)
		WD40 repeat	244..280	CDD:293791	10/54 (19%)
		WD40 repeat	288..325	CDD:293791	11/33 (33%)
		WD40 repeat	331..357	CDD:293791
LAF1	NP_013820.1	WD40	173..506	CDD:421866	74/366 (20%)
		WD40 repeat	176..221	CDD:293791	10/44 (23%)
		WD40 repeat	234..276	CDD:293791	4/42 (10%)
		WD40 repeat	281..315	CDD:293791	13/34 (38%)
		WD40 repeat	322..358	CDD:293791	8/35 (23%)
		WD40 repeat	363..400	CDD:293791	6/36 (17%)
		WD40 repeat	430..472	CDD:293791	8/41 (20%)
		WD40 repeat	480..502	CDD:293791	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870