DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and SWD3

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_009734.1	Gene:	SWD3 / 852472	SGDID:	S000000379	Length:	315	Species:	Saccharomyces cerevisiae

Alignment Length:	309	Identity:	106/309 - (34%)
Similarity:	159/309 - (51%)	Gaps:	33/309 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-----GHKLGISDVAWSSDSRLLVSG 132
            ||..| |.||:|::||.:....::    .||.. .:|:|     .|....|::.||.|.:.:.:.
Yeast    15 KATCA-KISPDGQFLAITQGLNIL----IYDIN-RRTVSQTLVTSHARPFSELCWSPDGQCIATA 73

  Fly   133 SDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAH 197
            |||.::::..||.| .|.|..||:..|....||.:.||:.:.|.|||::|||...|..:||:.||
Yeast    74 SDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137

  Fly   198 SDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN-------PPVSFVKFSPNGK 254
            |:.|.:|.. ..|.|::.|.|||||.||:|..:|.|||||..|.:       .|:|.||||.|.:
Yeast   138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202

  Fly   255 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI-------FANFSVTGGKWIVSGSEDNMVYI 312
            |:|..:||..:|:||...|..::|:.....||..:       |.|........::||.|:..:|.
Yeast   203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 267

  Fly   313 WNLQSKEVVQKLQG----HTDTVLCTACHPTENIIASAALENDKTIKLW 357
            ||..:|.::|.|.|    |:..|:...|.  .||:.|.||..|..:..|
Yeast   268 WNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLWRW 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	106/309 (34%)
		WD40 repeat	75..112	CDD:293791	11/41 (27%)
		WD40 repeat	118..154	CDD:293791	12/35 (34%)
		WD40 repeat	159..195	CDD:293791	15/35 (43%)
		WD40 repeat	202..237	CDD:293791	17/35 (49%)
		WD40 repeat	244..280	CDD:293791	15/35 (43%)
		WD40 repeat	288..325	CDD:293791	10/43 (23%)
		WD40 repeat	331..357	CDD:293791	8/25 (32%)
SWD3	NP_009734.1	WD40	17..314	CDD:238121	103/305 (34%)
		WD40 repeat	17..53	CDD:293791	11/41 (27%)
		WD40 repeat	59..94	CDD:293791	12/35 (34%)
		WD40 repeat	99..135	CDD:293791	15/35 (43%)
		WD40 repeat	142..178	CDD:293791	17/35 (49%)
		WD40 repeat	192..228	CDD:293791	15/35 (43%)
		WD40 repeat	236..284	CDD:293791	12/47 (26%)
		WD40 repeat	290..312	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1071
Isobase	1	0.950	-	0	Normalized mean entropy	S633
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46868
orthoMCL	1	0.900	-	-		OOG6_101464
Panther	1	1.100	-	-	LDO	PTHR22847
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.810