DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and WDR5b

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_192182.1	Gene:	WDR5b / 828189	AraportID:	AT4G02730	Length:	333	Species:	Arabidopsis thaliana

Alignment Length:	336	Identity:	190/336 - (56%)
Similarity:	244/336 - (72%)	Gaps:	6/336 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PSGPNSLQPNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASS 90
            |||.|.   .|.|...|.::.|:..|....: .||...|| ||.|||.|:|.||||.:|..|||:
plant     2 PSGGNG---TSNGVANANSTGNAGTSGNVPI-YKPYRHLK-TLEGHTAAISCVKFSNDGNLLASA 61

  Fly    91 SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWEL-STGKSLKTLKG 154
            |.||.:.:|.|.:........||..||||:||||||....|.|||.||::|:. |..:.||.|:|
plant    62 SVDKTMILWSATNYSLIHRYEGHSSGISDLAWSSDSHYTCSASDDCTLRIWDARSPYECLKVLRG 126

  Fly   155 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 219
            |:|:|||.||||.|||||||||||::|||:|:||||::.:.|||.|:|:||||||||||||:|:|
plant   127 HTNFVFCVNFNPPSNLIVSGSFDETIRIWEVKTGKCVRMIKAHSMPISSVHFNRDGSLIVSASHD 191

  Fly   220 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 284
            |.|:|||...|.||||||||.:|.|||.|||||||:||.||||:||||.:|:.||.||.||||.|
plant   192 GSCKIWDAKEGTCLKTLIDDKSPAVSFAKFSPNGKFILVATLDSTLKLSNYATGKFLKVYTGHTN 256

  Fly   285 EKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALE 349
            :.:||.:.||||.||:||||||||.||:|:||::.::|:|:||||.|:..:|||.:|.|:|:...
plant   257 KVFCITSAFSVTNGKYIVSGSEDNCVYLWDLQARNILQRLEGHTDAVISVSCHPVQNEISSSGNH 321

  Fly   350 NDKTIKLWKSD 360
            .||||::||.|
plant   322 LDKTIRIWKQD 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	176/294 (60%)
		WD40 repeat	75..112	CDD:293791	14/36 (39%)
		WD40 repeat	118..154	CDD:293791	19/36 (53%)
		WD40 repeat	159..195	CDD:293791	26/35 (74%)
		WD40 repeat	202..237	CDD:293791	25/34 (74%)
		WD40 repeat	244..280	CDD:293791	25/35 (71%)
		WD40 repeat	288..325	CDD:293791	22/36 (61%)
		WD40 repeat	331..357	CDD:293791	11/25 (44%)
WDR5b	NP_192182.1	WD40	26..>330	CDD:225201	178/305 (58%)
		WD40	35..330	CDD:238121	176/295 (60%)
		WD40 repeat	46..83	CDD:293791	14/36 (39%)
		WD40 repeat	89..126	CDD:293791	19/36 (53%)
		WD40 repeat	131..167	CDD:293791	26/35 (74%)
		WD40 repeat	174..209	CDD:293791	25/34 (74%)
		WD40 repeat	216..252	CDD:293791	25/35 (71%)
		WD40 repeat	260..297	CDD:293791	22/36 (61%)
		WD40 repeat	303..329	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D957291at2759
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.790