DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and PAAF1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001350485.1	Gene:	PAAF1 / 80227	HGNCID:	25687	Length:	393	Species:	Homo sapiens

Alignment Length:	310	Identity:	73/310 - (23%)
Similarity:	122/310 - (39%)	Gaps:	47/310 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAG----HTKA--VSAVKFSPNGEWLASSSA 92
            |...|.....||...|.|:..::.:..|....|....    .||:  :|..|.:.:.::||..:.
Human    23 PRCFGTAWVLTSFFPSYSDLDTVFITSNMIANFCCEPAEWVQTKSIHISCPKENASSKFLAPYTT 87

  Fly    93 DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSN 157
            ...|                |...|:.:..||...|.||.|.|.|:|:|:.|.|:..:.|:||..
Human    88 FSRI----------------HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVF 136

  Fly   158 YVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 222
            .|.||.|.|...:::||..|..::||......|:.|...|...:........|..:||:|.||..
Human   137 DVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTA 201

  Fly   223 RIWDTASGQCLKTLID-------------DDNPPVSFVKFSPN-------GKYILAATLDNTLKL 267
            |:||.....||..|.|             |::..:...:..|:       .|.:|.|..|..|:.
Human   202 RLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQC 266

  Fly   268 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQS 317
            ......:.:..:.|......|.|.:     |..:::|::|..:|..:::|
Human   267 LGLQSRQLVFLFIGSDAFNCCTFLS-----GFLLLAGTQDGNIYQLDVRS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	66/280 (24%)
		WD40 repeat	75..112	CDD:293791	5/36 (14%)
		WD40 repeat	118..154	CDD:293791	13/35 (37%)
		WD40 repeat	159..195	CDD:293791	12/35 (34%)
		WD40 repeat	202..237	CDD:293791	11/34 (32%)
		WD40 repeat	244..280	CDD:293791	6/42 (14%)
		WD40 repeat	288..325	CDD:293791	7/30 (23%)
		WD40 repeat	331..357	CDD:293791
PAAF1	NP_001350485.1	WD40	90..339	CDD:330360	59/243 (24%)
		WD40 repeat	96..133	CDD:293791	14/36 (39%)
		WD40 repeat	139..175	CDD:293791	11/35 (31%)
		WD40 repeat	180..223	CDD:293791	13/42 (31%)
		WD40 repeat	232..279	CDD:293791	6/46 (13%)
		WD40 repeat	284..318	CDD:293791	7/33 (21%)
		WD40 repeat	326..359	CDD:293791
		WD40 repeat	366..388	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810