DRSC/TRiP Functional Genomics Resources

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Protein Alignment wds and Apaf1

DIOPT Version :9

Sequence 1:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster
Sequence 2:NP_076469.1 Gene:Apaf1 / 78963 RGDID:620575 Length:1249 Species:Rattus norvegicus


Alignment Length:329 Identity:94/329 - (28%)
Similarity:162/329 - (49%) Gaps:31/329 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 SNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 110
            :..:..|.|.|.|:|          ||.||....||.:|:.:||..|||.::::.|..|:....|
  Rat   599 NKKTIKNLSRLVVRP----------HTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDI 653

  Fly   111 SGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSN--LIVS 173
            ..|:..:...|:|||...:.:.|.||.:|:|:..|||.:.|.:.||..|.||:|..:||  |:.:
  Rat   654 KAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEHSEQVNCCHFTNKSNHLLLAT 718

  Fly   174 GSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-- 236
            ||.|..:::||:...:|..|:..|::.|:...|:.|..|:.|.|.||..::||..|....|::  
  Rat   719 GSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINV 783

  Fly   237 ----IDDDNPP------VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE-KYCIF 290
                :..::||      |....:|.:|..|:.|..:..|.|..::.|...:.:|||.:. :||.|
  Rat   784 KRFFLSSEDPPEDVEVIVKCCSWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDF 848

  Fly   291 ANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIK 355
            :.:.    ...|.......|.:||:.|:..|...:||...|......|..:...:|:  :|:||:
  Rat   849 SPYD----HLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTAS--DDQTIR 907

  Fly   356 LWKS 359
            :|::
  Rat   908 VWET 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdsNP_001245503.1 WD40 64..358 CDD:238121 88/308 (29%)
WD40 repeat 75..112 CDD:293791 12/36 (33%)
WD40 repeat 118..154 CDD:293791 13/35 (37%)
WD40 repeat 159..195 CDD:293791 14/37 (38%)
WD40 repeat 202..237 CDD:293791 11/40 (28%)
WD40 repeat 244..280 CDD:293791 8/35 (23%)
WD40 repeat 288..325 CDD:293791 8/36 (22%)
WD40 repeat 331..357 CDD:293791 6/25 (24%)
Apaf1NP_076469.1 CARD_APAF1 7..92 CDD:260034
AAA_16 126..245 CDD:289934
NB-ARC 129..414 CDD:279299
WD40 <598..685 CDD:225201 29/95 (31%)
WD40 607..910 CDD:238121 92/318 (29%)
WD 1-1 613..652 15/48 (31%)
WD40 repeat 623..655 CDD:293791 11/31 (35%)
WD40 653..1038 CDD:225201 75/265 (28%)
WD 1-2 655..694 13/38 (34%)
WD40 repeat 661..697 CDD:293791 13/35 (37%)
WD 1-3 697..738 15/40 (38%)
WD40 repeat 702..740 CDD:293791 14/37 (38%)
WD 1-4 741..780 12/38 (32%)
WD40 repeat 747..789 CDD:293791 11/41 (27%)
WD 1-5 796..837 8/40 (20%)
WD40 repeat 801..837 CDD:293791 8/35 (23%)
WD 1-6 838..877 11/42 (26%)
WD40 repeat 843..882 CDD:293791 10/42 (24%)
WD 1-7 880..910 8/31 (26%)
WD40 repeat 885..909 CDD:293791 6/25 (24%)
Interpropeller linker. /evidence=ECO:0000250 910..921 0/2 (0%)
WD 2-1 922..958
WD 2-2 959..998
WD40 961..1235 CDD:238121
WD40 961..>1235 CDD:225201
WD40 repeat 964..1001 CDD:293791
WD 2-3 1001..1040
WD40 repeat 1006..1030 CDD:293791
WD 2-4 1042..1080
WD40 repeat 1048..1082 CDD:293791
WD 2-5 1083..1122
WD40 repeat 1089..1124 CDD:293791
WD 2-6 1125..1164
WD40 repeat 1130..1174 CDD:293791
WD 2-7 1176..1213
WD40 repeat 1181..1203 CDD:293791
WD 2-8 1214..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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