DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wds and Wsb1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_062627.3	Gene:	Wsb1 / 78889	MGIID:	1926139	Length:	421	Species:	Mus musculus

Alignment Length:	337	Identity:	89/337 - (26%)
Similarity:	137/337 - (40%)	Gaps:	70/337 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEW-----------LASSSADKL 95
            |..:||....||....|.....:.::||..:..........|.||           ||:...:..
Mouse    87 ARQNSNGGQKNKPPEHVIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGR 151

  Fly    96 IKIWGAYDGKFEKTISGHKLGISDVAWSSD-SRLLVSGSDDKTLKVWEL-STGKSLKTLKGHSNY 158
            ||||..|.||....:..|...:.|:.::.| |.||||.|.||||:||:| ..|..:|.|:.|.|:
Mouse   152 IKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAHQNW 216

  Fly   159 VFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 223
            |:.|.|:|..:::.|....::|.:|::.....::.|..|...|.|..|:.||:|:.::|||....
Mouse   217 VYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281

  Fly   224 IWDTASGQCLKT---LIDDDNPP---------VSFVKFSPNGKYILAATLDNTLKLW-------- 268
            :||..:|..|..   |.....|.         |..|.||.:|.::.:...|..::.|
Mouse   282 VWDPHNGDLLMEFGHLFPSPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPV 346

  Fly   269 ---DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIW----------------- 313
               ..|.|.|            |.|:    |.|..:.:|:.|..||.|
Mouse   347 QVAPLSNGLC------------CAFS----TDGSVLAAGTHDGSVYFWATPRQVPSLQHICRMSI 395

  Fly   314 -NLQSKEVVQKL 324
             .:.|.:.||||
Mouse   396 RRVMSTQEVQKL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	83/315 (26%)
		WD40 repeat	75..112	CDD:293791	12/47 (26%)
		WD40 repeat	118..154	CDD:293791	18/37 (49%)
		WD40 repeat	159..195	CDD:293791	7/35 (20%)
		WD40 repeat	202..237	CDD:293791	12/37 (32%)
		WD40 repeat	244..280	CDD:293791	10/46 (22%)
		WD40 repeat	288..325	CDD:293791	14/55 (25%)
		WD40 repeat	331..357	CDD:293791
Wsb1	NP_062627.3	WD 1	124..165		12/40 (30%)
		WD40	135..388	CDD:238121	73/268 (27%)
		WD40	<139..382	CDD:225201	73/258 (28%)
		WD 2	168..208		17/39 (44%)
		WD40 repeat	174..212	CDD:293791	18/37 (49%)
		WD 3	212..251		9/38 (24%)
		WD40 repeat	217..253	CDD:293791	7/35 (20%)
		WD 4	254..293		14/38 (37%)
		WD40 repeat	261..299	CDD:293791	13/37 (35%)
		WD 5	309..346		7/36 (19%)
		WD40 repeat	314..353	CDD:293791	7/38 (18%)
		SOCS	382..420	CDD:295349	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810