DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wds and wdsub1

DIOPT Version :9

Sequence 1:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster
Sequence 2:NP_001071237.1 Gene:wdsub1 / 777721 ZFINID:ZDB-GENE-061110-97 Length:487 Species:Danio rerio


Alignment Length:320 Identity:92/320 - (28%)
Similarity:148/320 - (46%) Gaps:41/320 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 TLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEK----TISGHKLGISDVAWSSDSR 127
            ||..|...|:.|.||  |:.||:.||||.|.::.:.|  |.:    .:|||..|:....:|:..:
Zfish     7 TLQSHRDDVNCVAFS--GDLLATCSADKSICVYSSRD--FSELPFSPLSGHGYGVHCCCFSACGQ 67

  Fly   128 LLVSGSDDKTLKVWELSTGKSLKTLK--GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKC 190
            .|.|.|.|.|..||.:.||:....|:  |.|. |..|.|:|.|:.:|||..|.|:.:||..:...
Zfish    68 YLASCSTDATTMVWSMDTGEIEAVLEHPGRSP-VRVCAFSPDSSHLVSGGSDGSIALWDFTSRTL 131

  Fly   191 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSP- 251
            .:|...:...:.|..|...|.:.::.|..|..|:||..    :..|..:.|.   .||..:|:| 
Zfish   132 RRTGVVNDTSIVACSFTPCGQMFITGSTYGDLRLWDLN----MNHLHAEKNAHDLGVSCAQFAPK 192

  Fly   252 -----NG--KYILAAT-LDNTLKLWDYS-------KGKCLKTYTGHKNEKY-CIFANFSVTGGKW 300
                 :|  ::.||:. .|:.||:|..|       |.:...|.||...... |.::    ..|:.
Zfish   193 MMKGTDGCVQFRLASCGQDSLLKIWIVSLLPSAGIKMQLAHTLTGQSAPVLSCAYS----PDGQM 253

  Fly   301 IVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            :||||.|..|.::......::..|..|...|...|..||..:||:.::  ||::.:|:.:
Zfish   254 LVSGSVDKTVTVYQADEGVLLYTLHQHDRYVTACAFSPTAPLIATGSM--DKSVNIWRME 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdsNP_001245503.1 WD40 64..358 CDD:238121 91/316 (29%)
WD40 repeat 75..112 CDD:293791 14/40 (35%)
WD40 repeat 118..154 CDD:293791 11/37 (30%)
WD40 repeat 159..195 CDD:293791 13/35 (37%)
WD40 repeat 202..237 CDD:293791 8/34 (24%)
WD40 repeat 244..280 CDD:293791 14/51 (27%)
WD40 repeat 288..325 CDD:293791 8/36 (22%)
WD40 repeat 331..357 CDD:293791 8/25 (32%)
wdsub1NP_001071237.1 WD40 4..309 CDD:238121 91/316 (29%)
WD 1 10..47 15/40 (38%)
WD40 repeat 17..52 CDD:293791 13/38 (34%)
WD40 50..>371 CDD:225201 75/273 (27%)
WD 2 52..93 13/40 (33%)
WD40 repeat 58..96 CDD:293791 11/37 (30%)
WD 3 95..134 14/39 (36%)
WD40 repeat 100..134 CDD:293791 12/33 (36%)
WD 4 137..176 9/42 (21%)
WD40 repeat 143..178 CDD:293791 9/38 (24%)
WD 5 179..227 12/47 (26%)
WD40 repeat 184..236 CDD:293791 14/51 (27%)
WD 6 237..276 9/42 (21%)
WD40 repeat 242..278 CDD:293791 8/39 (21%)
WD 7 279..318 10/35 (29%)
WD40 repeat 284..308 CDD:293791 8/25 (32%)
SAM_WDSUB1 343..414 CDD:188904
SAM 344..409 CDD:197735
RING 418..483 CDD:302633
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D957291at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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