DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Daw1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001359172.1	Gene:	Daw1 / 71227	MGIID:	1923089	Length:	428	Species:	Mus musculus

Alignment Length:	293	Identity:	97/293 - (33%)
Similarity:	163/293 - (55%)	Gaps:	7/293 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TLAGHTKAVSAVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLV 130
            ||.||...|.|:.| :|.|:.:|:.|.||..|:|.|..||...|..||...|..::::..|.::.
Mouse   142 TLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVA 206

  Fly   131 SGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLP 195
            :||.|.|.|:|::..|:.:.||.||...:...:|:...:.|::||||.:|.:||..||:.:.||.
Mouse   207 TGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLI 271

  Fly   196 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 260
            .|...:|:..||.|.|||::.|.|..|.:||..||:.:.||...|:..:... |...||.|..|:
Mouse   272 GHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSC-FDYTGKLIATAS 335

  Fly   261 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQ 325
            .|.|.::::.:..||:....||:.|...|  :|:..|.: :::||.|....||::|:.:.:|.|:
Mouse   336 ADGTARVYNATTRKCVTKLEGHEGEISKI--SFNPQGNR-LLTGSSDKTARIWDVQTGQCLQVLE 397

  Fly   326 GHTDTVLCTACHPTENIIASAALENDKTIKLWK 358
            ||||.:...|.:...||:.:.:  .|.:.::|:
Mouse   398 GHTDEIFSCAFNYKGNIVITGS--KDNSCRIWR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	96/291 (33%)
		WD40 repeat	75..112	CDD:293791	15/37 (41%)
		WD40 repeat	118..154	CDD:293791	10/35 (29%)
		WD40 repeat	159..195	CDD:293791	12/35 (34%)
		WD40 repeat	202..237	CDD:293791	15/34 (44%)
		WD40 repeat	244..280	CDD:293791	9/35 (26%)
		WD40 repeat	288..325	CDD:293791	10/36 (28%)
		WD40 repeat	331..357	CDD:293791	4/25 (16%)
Daw1	NP_001359172.1	WD40	99..133	CDD:197651
		WD40 repeat	109..145	CDD:293791	2/2 (100%)
		WD40	139..428	CDD:238121	96/291 (33%)
		WD40 repeat	150..188	CDD:293791	15/37 (41%)
		WD40 repeat	194..230	CDD:293791	10/35 (29%)
		WD40 repeat	235..271	CDD:293791	12/35 (34%)
		WD40 repeat	278..313	CDD:293791	15/34 (44%)
		WD40 repeat	319..355	CDD:293791	9/36 (25%)
		WD40 repeat	361..397	CDD:293791	10/38 (26%)
		WD40 repeat	403..427	CDD:293791	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920