DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and WDR13

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001334146.1	Gene:	WDR13 / 64743	HGNCID:	14352	Length:	485	Species:	Homo sapiens

Alignment Length:	370	Identity:	93/370 - (25%)
Similarity:	169/370 - (45%)	Gaps:	57/370 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PNSLQPNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAG-------HT-KAVSAVKFSPNGE 85
            |.|:.|        |:::.:|.:.....|:..||    ..||       |. :||..|:|:.:..
Human   133 PGSVVP--------TSAAEASRAMAGDTSLSENY----AFAGMYHVFDQHVDEAVPRVRFANDDR 185

  Fly    86 W-LASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGK 147
            . ||..|.|..|.:......  ...:.:.||..|:||.|||..:.:|||.|.|.|:::|....|:
Human   186 HRLACCSLDGSISLCQLVPAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGR 250

  Fly   148 SLKTLKG-HSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVRTGKCLKTLPAH-SDPVSAVHFNRD 209
            .::.:.. .|..:.||.|.| .:||.|.|:...:|.:.::.|||.:|...:. :..|.|:.|:..
Human   251 CIREIPDPDSAELLCCTFQPVNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKLTGRVLALSFDAP 315

  Fly   210 GSLIVSSSYDG--LCRIWDTASGQCLKT--LIDDDNPPVSFVKF---------SPN-------GK 254
            |.|:.:....|  ...::|.|:|:..|.  |:..:..||:.:..         .|:       .|
Human   316 GRLLWAGDDRGSVFSFLFDMATGKLTKAKRLVVHEGSPVTSISARSWVSREARDPSLLINACLNK 380

  Fly   255 YILAATLDN--TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQ- 316
            .:|...:||  ||:|   .:...::..:......:|...:|  ..|..:|:||||..|:.::::
Human   381 LLLYRVVDNEGTLQL---KRSFPIEQSSHPVRSIFCPLMSF--RQGACVVTGSEDMCVHFFDVER 440

  Fly   317 -SKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
             :|..|.|||||:..||..:.:..|:::||:  :....:.:|:.:
Human   441 AAKAAVNKLQGHSAPVLDVSFNCDESLLASS--DASGMVIVWRRE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	84/331 (25%)
		WD40 repeat	75..112	CDD:293791	8/39 (21%)
		WD40 repeat	118..154	CDD:293791	13/35 (37%)
		WD40 repeat	159..195	CDD:293791	13/36 (36%)
		WD40 repeat	202..237	CDD:293791	9/38 (24%)
		WD40 repeat	244..280	CDD:293791	9/53 (17%)
		WD40 repeat	288..325	CDD:293791	12/38 (32%)
		WD40 repeat	331..357	CDD:293791	5/25 (20%)
WDR13	NP_001334146.1	WD 1	162..202		11/39 (28%)
		WD40	175..481	CDD:421866	80/312 (26%)
		WD 2	208..246		15/37 (41%)
		WD40 repeat	221..258	CDD:293791	13/36 (36%)
		WD 3	250..290		10/39 (26%)
		WD40 repeat	263..300	CDD:293791	13/36 (36%)
		WD 4	295..335		7/39 (18%)
		WD40 repeat	308..347	CDD:293791	9/38 (24%)
		WD 5	341..389		7/47 (15%)
		WD40 repeat	354..400	CDD:293791	9/48 (19%)
		WD 6	394..438		10/48 (21%)
		WD40 repeat	408..450	CDD:293791	12/43 (28%)
		WD 7	444..482		12/39 (31%)
		WD40 repeat	456..480	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810