DRSC/TRiP Functional Genomics Resources

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Protein Alignment wds and apaf1

DIOPT Version :9

Sequence 1:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster
Sequence 2:NP_571683.1 Gene:apaf1 / 58131 ZFINID:ZDB-GENE-000616-4 Length:1261 Species:Danio rerio


Alignment Length:375 Identity:91/375 - (24%)
Similarity:154/375 - (41%) Gaps:77/375 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 NKSSLSVK-PNYTL----------KFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIW------ 99
            |.|.|:|. .:||:          |...:||...|..|:|||:|..|.|||.|:.|::|      
Zfish   853 NSSLLAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDRVH 917

  Fly   100 --GAYDGKFEKTISGHKLGISDVAWSSDSRLLV-------------------------------- 130
              .|...|.:..:.......:.:|..|.:||.|                                
Zfish   918 TSSAVALKRDTDVLSSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSRIRCSCISRNAAFVA 982

  Fly   131 SGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLP 195
            .||:|.|::|.|:.:.|:...|.||:..|..|.|.....::::.|.|.::|:|..|||:|: .|.
Zfish   983 LGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-VLQ 1046

  Fly   196 AHSDPVSAVHFNRDGSL--IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 258
            .|.:||...|.....|.  :.|.|:||..::||...||.|:.|:..:...:| ...|.:|:....
Zfish  1047 GHMEPVRKFHLLSSSSSPHLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLS-CDVSSDGRLFAT 1110

  Fly   259 ATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNMVYIWNL------- 315
            .:.:.|.|:|..:..|.|....|||: .:.|.|:    ...|.:.:|.::..:.:|::       
Zfish  1111 TSANRTAKVWSSASWKMLFLLEGHKDCVRSCRFS----WDNKRLATGDDNGEIRLWSMLDGALLK 1171

  Fly   316 ----QSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSDT 361
                .:|:.:...  |...|......|...::.|.|    ..||.|..::
Zfish  1172 ICPRDTKDSMNSY--HAGWVTDLHFSPDNRVLVSTA----GYIKWWSVES 1215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdsNP_001245503.1 WD40 64..358 CDD:238121 84/357 (24%)
WD40 repeat 75..112 CDD:293791 15/44 (34%)
WD40 repeat 118..154 CDD:293791 13/67 (19%)
WD40 repeat 159..195 CDD:293791 11/35 (31%)
WD40 repeat 202..237 CDD:293791 11/36 (31%)
WD40 repeat 244..280 CDD:293791 8/35 (23%)
WD40 repeat 288..325 CDD:293791 6/47 (13%)
WD40 repeat 331..357 CDD:293791 6/25 (24%)
apaf1NP_571683.1 DD 7..92 CDD:301326
NB-ARC 132..411 CDD:279299
P-loop_NTPase 150..297 CDD:304359
WD 1 615..654
WD40 616..912 CDD:238121 21/58 (36%)
WD40 repeat 625..657 CDD:293791
WD40 641..1042 CDD:225201 49/188 (26%)
WD 2 657..696
WD40 repeat 663..699 CDD:293791
WD 3 700..743
WD40 repeat 705..745 CDD:293791
WD 4 746..785
WD40 repeat 752..796 CDD:293791
WD 5 798..836
WD40 repeat 803..841 CDD:293791
WD 6 840..879 7/25 (28%)
WD40 851..1256 CDD:225201 91/375 (24%)
WD40 877..1212 CDD:238121 84/346 (24%)
WD 7 882..921 15/38 (39%)
WD40 repeat 887..911 CDD:293791 12/23 (52%)
WD40 repeat 960..1005 CDD:293791 7/44 (16%)
WD 8 964..1003 7/38 (18%)
WD 9 1006..1045 13/39 (33%)
WD40 repeat 1011..1046 CDD:293791 11/35 (31%)
WD 10 1047..1088 14/40 (35%)
WD 11 1091..1130 8/39 (21%)
WD40 repeat 1096..1132 CDD:293791 8/36 (22%)
WD 12 1133..1172 8/42 (19%)
WD40 repeat 1138..1162 CDD:293791 4/27 (15%)
WD 13 1184..1223 8/38 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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