DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and dcaf11

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001026845.1	Gene:	dcaf11 / 567578	ZFINID:	ZDB-GENE-050809-116	Length:	541	Species:	Danio rerio

Alignment Length:	426	Identity:	98/426 - (23%)
Similarity:	161/426 - (37%)	Gaps:	121/426 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LPTAPSG-------PNSLQPNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVK 79
            |.||.||       .:.|.....|:...::.|:...|...|..:..:...|.|   :.:.|....
Zfish   122 LATASSGLKGRHSFTHMLAEREQGRCRGSSFSHGECSRIRSHFLPNHVVYKDT---YQQKVFCGV 183

  Fly    80 FSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLG--ISDVAWSSDSRLLVSGSDDKTLKV 140
            :|..|....|:..|:.|:::....|:|  :||:....:|  |.||.::.|:|.::..|
Zfish   184 YSDEGNMFLSACQDQNIRLYDTSRGRFTLKKTVKARDVGWSILDVCFTPDARCVLYSS------- 241

  Fly   141 WELSTGKSLKTLKGHSNYVFCC------------NFNPQSNL--------------IVSGSFDES 179
            |              |:|:..|            :.||....              |:.|:.|..
Zfish   242 W--------------SDYIHVCSVDGDNETHTALDLNPDERRFCVFSLAASTDGKEILGGANDGC 292

  Fly   180 VRIWDVRTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 243
            :.::|....|....:.||.|.|:||.| :....|:.|.|.|.||::||.      :||.:|...|
Zfish   293 LYVFDREQNKRTLKIDAHEDDVNAVAFADSSSQLLFSGSDDALCKVWDR------RTLREDRPQP 351

  Fly   244 V----------SFVKFSPNGKYILAATLDNTLKLWDYSK-------------------------- 272
            |          :|:....:.:|:::.:.|.|:||||..|
Zfish   352 VGHLAGHRDGITFIHSKGDARYLISNSKDQTIKLWDVRKFSPKEGLAASRLAVTQQNWDYRWQQV 416

  Fly   273 -GKCLK-----------TYTGHKNEKYCIFANFS---VTGGKWIVSGSEDNMVYIWNLQSKEVVQ 322
             .:.||           ||.||......|...||   .||.|:|.:|.....:.|:::.:..||.
Zfish   417 PQRALKRHKLTGDTSVMTYRGHGVLHTLIRCRFSPEFSTGQKFIYTGCSTGKIVIYDVLTGSVVC 481

  Fly   323 KLQGHTDTVLCTACHPTENIIASAALENDKTIKLWK 358
            ||..|...|...:.||..|.:.|::.  |..|:||:
Zfish   482 KLSNHDACVRDVSWHPYNNNMVSSSW--DGAIRLWE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	87/375 (23%)
		WD40 repeat	75..112	CDD:293791	10/38 (26%)
		WD40 repeat	118..154	CDD:293791	6/35 (17%)
		WD40 repeat	159..195	CDD:293791	8/61 (13%)
		WD40 repeat	202..237	CDD:293791	12/35 (34%)
		WD40 repeat	244..280	CDD:293791	13/83 (16%)
		WD40 repeat	288..325	CDD:293791	12/39 (31%)
		WD40 repeat	331..357	CDD:293791	7/25 (28%)
dcaf11	NP_001026845.1	WD40	175..515	CDD:225201	85/368 (23%)
		WD40	178..515	CDD:295369	85/365 (23%)
		WD40 repeat	225..265	CDD:293791	10/60 (17%)
		WD40 repeat	273..309	CDD:293791	5/35 (14%)
		WD40 repeat	314..356	CDD:293791	17/47 (36%)
		WD40 repeat	390..436	CDD:293791	4/45 (9%)
		WD40 repeat	448..474	CDD:293791	8/25 (32%)
		WD40 repeat	490..514	CDD:293791	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810