DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wds and ahi1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001306918.1	Gene:	ahi1 / 562701	ZFINID:	ZDB-GENE-060803-1	Length:	1190	Species:	Danio rerio

Alignment Length:	376	Identity:	99/376 - (26%)
Similarity:	178/376 - (47%)	Gaps:	70/376 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GATTSS--NSSASNKSSLSV----------------------KPNYTLK------FTLAGHTKAV 75
            |:|:.|  ||..:||:|..:                      ||.::.:      |||.
Zfish   495 GSTSYSELNSEMTNKTSTQIQESKAETMKWSRMPGQVCRIPNKPMHSFRGGQMGCFTLC------ 553

  Fly    76 SAVKFSPNGEWLASSSADK---LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKT 137
                ||.:|..||::.||:   .|.|:....||...:.:||...:.|:.||.|.:.|::.|.|.|
Zfish   554 ----FSHDGRALAAACADRDAFPIIIYEIPSGKVLSSFNGHLSVVYDLCWSRDDKGLLTASSDGT 614

  Fly   138 LKVWELSTGKSL--KTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVR----TGKCLKTLP 195
            ::||.:...::|  |||. |.::|:|..|:||: :|:.:|.:|..:|:|:|.    .|:.|:...
Zfish   615 VRVWNVERLQTLAHKTLP-HPSFVYCAKFHPQAQSLVATGGYDGVLRVWNVDVQDVNGQLLQEFD 678

  Fly   196 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT---------ASGQC-----LKTLIDDDNPPVSF 246
            .|...::.:.|:.:||.:.|:...||..:|.|         |:.|.     :|. .|.:...::.
Zfish   679 GHKTFINTLCFDPEGSRMFSADNSGLIIVWGTKVMPGSRRGATSQWSIEREIKE-ADLNGISINS 742

  Fly   247 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVY 311
            ::..|||:.:|....|:.|::.|. :...:|.|.|..|.:..|.:.|:.. |.:|.:||||.:.|
Zfish   743 LEVHPNGRRLLIHAKDSVLRVMDL-RILAVKKYIGATNYRDRINSTFTPC-GSFIFAGSEDGLAY 805

  Fly   312 IWNLQSKEVVQKLQG--HTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            :||.::.:.|.....  ::..:...|.||.||::|......::.|.|:..|
Zfish   806 VWNSETGDQVAVYSELCYSSALRAVAFHPHENMVAFCCFGQNQPIHLYLYD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	88/325 (27%)
		WD40 repeat	75..112	CDD:293791	11/39 (28%)
		WD40 repeat	118..154	CDD:293791	14/37 (38%)
		WD40 repeat	159..195	CDD:293791	13/40 (33%)
		WD40 repeat	202..237	CDD:293791	11/48 (23%)
		WD40 repeat	244..280	CDD:293791	8/35 (23%)
		WD40 repeat	288..325	CDD:293791	12/36 (33%)
		WD40 repeat	331..357	CDD:293791	7/25 (28%)
ahi1	NP_001306918.1	WD40	486..901	CDD:225201	99/376 (26%)
		WD40	540..840	CDD:238121	85/313 (27%)
		WD40 repeat	549..589	CDD:293791	14/49 (29%)
		WD40 repeat	595..632	CDD:293791	13/36 (36%)
		WD40 repeat	637..678	CDD:293791	13/40 (33%)
		WD40 repeat	685..729	CDD:293791	10/43 (23%)
		WD40 repeat	740..775	CDD:293791	8/35 (23%)
		WD40 repeat	783..820	CDD:293791	12/37 (32%)
		SH3_AHI-1	1026..1077	CDD:212746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910