Protein Alignment wds and WDR5B

DIOPT Version :10

• Sequence 1: NP_524984.1
• Gene: wds / 53428
• FlyBaseID: FBgn0040066
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_061942.2
• Gene: WDR5B / 54554
• HGNCID: 17826
• Length: 330
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 259/319 - (81%)
• Similarity: 286/319 - (89%)
• Gaps: 0/319 - (0%)

  Fly    42 ATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKF 106
            |..:.:|||:....:...|||.||.||.|||:|||:||||||||||||||||:||.||||||||:
Human    11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75

  Fly   107 EKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLI 171
            |||:.||.|.||||||||||..|||.|||||||:|::.:||.||||||||||||||||||.||||
Human    76 EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140

  Fly   172 VSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 236
            :||||||:|:||:|:||||||||.||||||||||||..||||||.||||||||||.|||||||||
Human   141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205

  Fly   237 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 301
            :||||||||||||||||||||.|||||||||||||:|:|||||||||||||||||||||||||||
Human   206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270

  Fly   302 VSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            |||||||:|||||||:||:|||||||||.|:..|||||||:|||||||||||||||.|:
Human   271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_524984.1	WD40	<63..361	CDD:441893	252/298 (85%)
		WD40 repeat	75..112	CDD:293791	31/36 (86%)
		WD40 repeat	118..154	CDD:293791	26/35 (74%)
		WD40 repeat	159..195	CDD:293791	29/35 (83%)
		WD40 repeat	202..237	CDD:293791	30/34 (88%)
		WD40 repeat	244..280	CDD:293791	32/35 (91%)
		WD40 repeat	288..325	CDD:293791	33/36 (92%)
		WD40 repeat	331..357	CDD:293791	21/25 (84%)
WDR5B	NP_061942.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		4/14 (29%)
		WD40	<36..326	CDD:441893	247/289 (85%)
		WD 1	39..78		33/38 (87%)
		WD40 repeat	44..81	CDD:293791	31/36 (86%)
		WD 2	81..122		29/40 (73%)
		WD40 repeat	87..123	CDD:293791	26/35 (74%)
		WD 3	124..164		33/39 (85%)
		WD40 repeat	128..164	CDD:293791	29/35 (83%)
		WD 4	165..204		34/38 (89%)
		WD40 repeat	171..206	CDD:293791	30/34 (88%)
		DDB1-binding motif	188..192		3/3 (100%)
		WD 5	208..249		37/40 (93%)
		WD40 repeat	213..249	CDD:293791	32/35 (91%)
		WD 6	252..292		36/39 (92%)
		WD40 repeat	257..294	CDD:293791	33/36 (92%)
		WD 7	295..330		28/35 (80%)
		WD40 repeat	300..326	CDD:293791	21/25 (84%)