DRSC/TRiP Functional Genomics Resources

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Protein Alignment wds and WDR5B

DIOPT Version :9

Sequence 1:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster
Sequence 2:NP_061942.2 Gene:WDR5B / 54554 HGNCID:17826 Length:330 Species:Homo sapiens


Alignment Length:319 Identity:259/319 - (81%)
Similarity:286/319 - (89%) Gaps:0/319 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 ATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKF 106
            |..:.:|||:....:...|||.||.||.|||:|||:||||||||||||||||:||.||||||||:
Human    11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75

  Fly   107 EKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLI 171
            |||:.||.|.||||||||||..|||.|||||||:|::.:||.||||||||||||||||||.||||
Human    76 EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140

  Fly   172 VSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 236
            :||||||:|:||:|:||||||||.||||||||||||..||||||.||||||||||.|||||||||
Human   141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205

  Fly   237 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 301
            :||||||||||||||||||||.|||||||||||||:|:|||||||||||||||||||||||||||
Human   206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270

  Fly   302 VSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            |||||||:|||||||:||:|||||||||.|:..|||||||:|||||||||||||||.|:
Human   271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdsNP_001245503.1 WD40 64..358 CDD:238121 250/293 (85%)
WD40 repeat 75..112 CDD:293791 31/36 (86%)
WD40 repeat 118..154 CDD:293791 26/35 (74%)
WD40 repeat 159..195 CDD:293791 29/35 (83%)
WD40 repeat 202..237 CDD:293791 30/34 (88%)
WD40 repeat 244..280 CDD:293791 32/35 (91%)
WD40 repeat 288..325 CDD:293791 33/36 (92%)
WD40 repeat 331..357 CDD:293791 21/25 (84%)
WDR5BNP_061942.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 4/14 (29%)
WD40 33..326 CDD:238121 249/292 (85%)
WD 1 39..78 33/38 (87%)
WD40 repeat 44..81 CDD:293791 31/36 (86%)
WD 2 81..122 29/40 (73%)
WD40 repeat 87..123 CDD:293791 26/35 (74%)
WD 3 124..164 33/39 (85%)
WD40 repeat 128..164 CDD:293791 29/35 (83%)
WD 4 165..204 34/38 (89%)
WD40 repeat 171..206 CDD:293791 30/34 (88%)
DDB1-binding motif 188..192 3/3 (100%)
WD 5 208..249 37/40 (93%)
WD40 repeat 213..249 CDD:293791 32/35 (91%)
WD 6 252..292 36/39 (92%)
WD40 repeat 257..294 CDD:293791 33/36 (92%)
WD 7 295..330 28/35 (80%)
WD40 repeat 300..326 CDD:293791 21/25 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147705
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53955
OrthoDB 1 1.010 - - D368256at33208
OrthoFinder 1 1.000 - - FOG0002159
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101464
Panther 1 1.100 - - O PTHR22847
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1422
SonicParanoid 1 1.000 - - X2149
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.750

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