DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Nup37

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001262950.1	Gene:	Nup37 / 43040	FlyBaseID:	FBgn0039301	Length:	320	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	63/307 - (20%)
Similarity:	118/307 - (38%)	Gaps:	56/307 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PNSVGQPGATTSSNSSASNK-----SSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSAD 93
            |...|:.|.|...:.....|     |:|:..|:.:|..|              ||...|.:::..
  Fly    48 PEESGEFGYTRLQDMDLGEKEQRSVSALAFSPDTSLNCT--------------PNNVTLCAANGS 98

  Fly    94 KLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHS 156
            :| |::....|:|.  :.:.||...::||:|..|..||.|.|||.|.:.|..:.|.......|.|
  Fly    99 QL-KLYRTDLGQFTSLQVLRGHGDYVNDVSWVCDGELLASVSDDFTCRFWTTTGGGENVITFGLS 162

  Fly   157 NYVFCCNFNPQS-NLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 220
            :.......:|:. |.::.......:.:::|...:.:.::.:...|:.:..:.....|.::|...|
  Fly   163 SAGMSVKSHPEDPNKVLVAEKKGIIHLYNVTLKQTVISVESPKFPLMSADWAHSNRLFITSLAGG 227

  Fly   221 LCRIWDTASGQCLKTLIDDDNPPV-----SFVKFSP-NGKYILAATLDNTLKLWDYSK-----GK 274
            ....||..     :..:..|...|     ..|:|:| :.:.::|..:..|||::....     ..
  Fly   228 DVVTWDLN-----RPYVPADVKQVHEDCGRVVRFAPGSSEMVIAMVIGLTLKVFAAKSTVPLLEA 287

  Fly   275 CLKTYTG---HKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSK 318
            .||:|.|   |:...|              :|...|..:..|.:|.|
  Fly   288 SLKSYGGMAWHQRLPY--------------ISAVSDRKLLFWKVQMK 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	55/272 (20%)
		WD40 repeat	75..112	CDD:293791	7/38 (18%)
		WD40 repeat	118..154	CDD:293791	13/35 (37%)
		WD40 repeat	159..195	CDD:293791	3/36 (8%)
		WD40 repeat	202..237	CDD:293791	5/34 (15%)
		WD40 repeat	244..280	CDD:293791	10/46 (22%)
		WD40 repeat	288..325	CDD:293791	5/31 (16%)
		WD40 repeat	331..357	CDD:293791
Nup37	NP_001262950.1	WD40	71..320	CDD:295369	57/282 (20%)
		WD40	<71..318	CDD:225201	56/280 (20%)
		WD40 repeat	72..118	CDD:293791	12/60 (20%)
		WD40 repeat	124..160	CDD:293791	13/35 (37%)
		WD40 repeat	165..202	CDD:293791	3/36 (8%)
		WD40 repeat	209..245	CDD:293791	6/40 (15%)
		WD40 repeat	252..286	CDD:293791	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810