DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wds and CG9945

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	84/410 - (20%)
Similarity:	167/410 - (40%)	Gaps:	104/410 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VVHPPQQPLPTAPSGPNSLQPNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAV 78
            :||..||            :.|.:..|.:.:.|.:.....|:|.: ||......::..:| :...
  Fly    84 LVHALQQ------------RENGLASPHSASFSKNQQRYISNLYI-PNKKATRLMSLESK-IFVT 134

  Fly    79 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSRLLVSGSD------DK 136
            ||:.:|..|.::..|..::|:....|.:...   :::...||.|| .|:....:|..      .:
  Fly   135 KFNRSGSKLLTACQDGFVRIYDGAKGTYHLL---NRIRARDVEWSIIDADFSPNGEHFAYSTWSR 196

  Fly   137 TLKVWELSTGK------SLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLP 195
            :|.:..::.|:      .:..|..|...:|...::|..:.|:.||.:.:|.:.|:|| :..:.|.
  Fly   197 SLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRT-RNTQILR 260

  Fly   196 AHSDP---VSAVHF--NRDGSLIVSSSYDGLCRIWD---TASGQCLK-------------TLIDD 239
            .|..|   |::|.|  ::|.::|::...|||.:::|   |...:.|.             |.||.
  Fly   261 THRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDS 325

  Fly   240 DNPPVSFVKFSPNGKYILAATLDNTLKLWD---------------------------------YS 271
            .|          :|.::|:.:.|.::|:||                                 |:
  Fly   326 RN----------DGYHVLSNSKDQSIKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYN 380

  Fly   272 KGKCLK------TYTGHKNEKYCIFANFS---VTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGH 327
            ..|.|:      ||.||:..|..:.|.||   .||.::|.:|.....:.|:::.:.::.:.::||
  Fly   381 PHKPLEGDSSIMTYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGH 445

  Fly   328 TDTVLCTACHPTENIIASAA 347
            ...:.....||..:.|.|.:
  Fly   446 RTVIRDLDWHPDRSEIVSGS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	73/360 (20%)
		WD40 repeat	75..112	CDD:293791	7/36 (19%)
		WD40 repeat	118..154	CDD:293791	9/48 (19%)
		WD40 repeat	159..195	CDD:293791	9/35 (26%)
		WD40 repeat	202..237	CDD:293791	11/52 (21%)
		WD40 repeat	244..280	CDD:293791	10/74 (14%)
		WD40 repeat	288..325	CDD:293791	8/39 (21%)
		WD40 repeat	331..357	CDD:293791	4/17 (24%)
CG9945	NP_611494.1	WD40	128..467	CDD:295369	73/353 (21%)
		WD40 repeat	131..170	CDD:293791	7/41 (17%)
		WD40	<133..478	CDD:225201	72/347 (21%)
		WD40 repeat	178..220	CDD:293791	5/41 (12%)
		WD40 repeat	225..260	CDD:293791	9/35 (26%)
		WD40 repeat	270..314	CDD:293791	10/43 (23%)
		WD40 repeat	323..395	CDD:293791	13/81 (16%)
		WD40 repeat	403..443	CDD:293791	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810