DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Daw1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001020196.1	Gene:	Daw1 / 363267	RGDID:	1561436	Length:	415	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	97/293 - (33%)
Similarity:	165/293 - (56%)	Gaps:	7/293 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TLAGHTKAVSAVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLV 130
            ||.||...|.|:.| :|.|:.:|:.|.||..|:|.|..||...|..||...|..::::..|.::.
  Rat   129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVA 193

  Fly   131 SGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLP 195
            :||.|.|.|:|::.:|:.:.||.||...:...:|:...:.|::||||.:|.:||..||:.:.||.
  Rat   194 TGSMDTTAKLWDIQSGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLI 258

  Fly   196 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 260
            .|...:|:..|:.|.|||::.|.|..|.:||..||:|:.||...|:..:... |...||.|..|:
  Rat   259 GHCAEISSALFSWDCSLILTGSMDKTCMLWDATSGKCVATLTGHDDEILDSC-FDYTGKLIATAS 322

  Fly   261 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQ 325
            .|.|.::::.:..||:....||:.|...|  :|:..|.: :::||.|....||::|:.:.:|.|:
  Rat   323 ADGTARVYNATTRKCITKLEGHEGEISKI--SFNPQGNR-LLTGSSDKTARIWDVQTGQCLQVLE 384

  Fly   326 GHTDTVLCTACHPTENIIASAALENDKTIKLWK 358
            ||||.:...|.:...||:.:.:  .|.:.::|:
  Rat   385 GHTDEIFSCAFNYKGNIVITGS--KDNSCRIWR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	96/291 (33%)
		WD40 repeat	75..112	CDD:293791	15/37 (41%)
		WD40 repeat	118..154	CDD:293791	10/35 (29%)
		WD40 repeat	159..195	CDD:293791	12/35 (34%)
		WD40 repeat	202..237	CDD:293791	15/34 (44%)
		WD40 repeat	244..280	CDD:293791	9/35 (26%)
		WD40 repeat	288..325	CDD:293791	10/36 (28%)
		WD40 repeat	331..357	CDD:293791	4/25 (16%)
Daw1	NP_001020196.1	WD40	86..120	CDD:197651
		WD 1	90..129		97/293 (33%)
		WD40 repeat	96..132	CDD:293791	2/2 (100%)
		WD40	126..415	CDD:238121	96/291 (33%)
		WD 2	132..174		17/41 (41%)
		WD40 repeat	137..175	CDD:293791	15/37 (41%)
		WD 3	175..214		11/38 (29%)
		WD40 repeat	181..217	CDD:293791	10/35 (29%)
		WD 4	217..256		13/38 (34%)
		WD40 repeat	222..258	CDD:293791	12/35 (34%)
		WD 5	259..298		15/38 (39%)
		WD40 repeat	265..300	CDD:293791	15/34 (44%)
		WD 6	301..340		10/39 (26%)
		WD40 repeat	306..342	CDD:293791	9/36 (25%)
		WD 7	343..384		13/43 (30%)
		WD40 repeat	348..384	CDD:293791	10/38 (26%)
		WD 8	386..415		7/30 (23%)
		WD40 repeat	390..414	CDD:293791	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920