DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and wdr13

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001018867.1	Gene:	wdr13 / 334827	ZFINID:	ZDB-GENE-050522-274	Length:	482	Species:	Danio rerio

Alignment Length:	370	Identity:	88/370 - (23%)
Similarity:	171/370 - (46%)	Gaps:	57/370 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PNSLQPNSVGQPGATTSSNSSASNKSSLSVKPNYTLKFTLAG-------HT-KAVSAVKFSPNGE 85
            |.||.|.||.:.....:.:::.|.        ||    ..||       |. .||..::|:.:.:
Zfish   130 PGSLVPTSVAEASRAMAGDTTLSE--------NY----AFAGMHHIFDQHVDSAVPRLQFANDDK 182

  Fly    86 -WLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGK 147
             .||..|.|..:.|.  .......:.|:.||...::|.|||..:.::||.|.|.||::|....|:
Zfish   183 HLLACCSLDGTLSIMTLSPPPPTVKVTLKGHAGPVTDFAWSLSNDIIVSTSKDGTLRIWNTEDGR 247

  Fly   148 SLK-TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVRTGKCLKTLPAH-SDPVSAVHFNRD 209
            .:: .:....:.:.||.|.| .:||.|.|:..:.:::.::.|||.:|...:. :..|.::.|:..
Zfish   248 CIREVVDPEGSELLCCTFQPVNNNLTVVGNSKQHLQVVNISTGKKVKGGSSKLTGRVLSLSFDAP 312

  Fly   210 GSLIVSSSYDG--LCRIWDTASGQCLKT--LIDDDNPPVSFVKF---------SPN-------GK 254
            |.::.:....|  ...::|.|:|:..|.  |:.::...:|.:..         .|:       .|
Zfish   313 GRILWAGDDRGSIFSFLFDMATGKLTKAKRLVVNEGSSISSISARSWISREARDPSLLVNACVNK 377

  Fly   255 YILAATLDN--TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQ- 316
            .:|...:||  ||:|   .:...::..:...:..:|...:|  ..|..:|:||||..||.::::
Zfish   378 LLLYRVVDNEGTLQL---KRSFPIQHGSQPLHSIFCPLMSF--RQGACVVTGSEDACVYFFDVER 437

  Fly   317 -SKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
             :|.:|.|||||:..||..:.:..|:::||:  :....:.:|:.:
Zfish   438 NTKAIVNKLQGHSGPVLDVSFNCDESLLASS--DASGMVIIWRRE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	78/331 (24%)
		WD40 repeat	75..112	CDD:293791	8/39 (21%)
		WD40 repeat	118..154	CDD:293791	12/36 (33%)
		WD40 repeat	159..195	CDD:293791	12/36 (33%)
		WD40 repeat	202..237	CDD:293791	7/38 (18%)
		WD40 repeat	244..280	CDD:293791	9/53 (17%)
		WD40 repeat	288..325	CDD:293791	13/38 (34%)
		WD40 repeat	331..357	CDD:293791	5/25 (20%)
wdr13	NP_001018867.1	WD40	<162..482	CDD:225201	77/326 (24%)
		WD40 repeat	173..212	CDD:293791	7/38 (18%)
		WD40	209..478	CDD:295369	67/275 (24%)
		WD40 repeat	217..253	CDD:293791	12/35 (34%)
		WD40 repeat	261..297	CDD:293791	12/35 (34%)
		WD40 repeat	304..400	CDD:293791	18/98 (18%)
		WD40 repeat	350..397	CDD:293791	9/49 (18%)
		WD40 repeat	408..447	CDD:293791	13/40 (33%)
		WD40 repeat	453..477	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810